Nocturnal hypoglycaemia in Type 1 diabetic patients, assessed with continuous glucose monitoring: frequency, duration and associations
Aims We quantified the occurrence and duration of nocturnal hypoglycaemia in individuals with Type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII) or multiple‐injection therapy (MIT) using a continuous subcutaneous glucose sensor. Methods A microdialysis sensor was worn at...
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| Veröffentlicht in: | Diabetic medicine 2007-05, Vol.24 (5), p.527-532 |
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| container_title | Diabetic medicine |
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| creator | Wentholt, I. M. E. Maran, A. Masurel, N. Heine, R. J. Hoekstra, J. B. L. DeVries, J. H. |
| description | Aims We quantified the occurrence and duration of nocturnal hypoglycaemia in individuals with Type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII) or multiple‐injection therapy (MIT) using a continuous subcutaneous glucose sensor.
Methods A microdialysis sensor was worn at home by 24 patients on CSII (mean HbA1c 7.8 ± 0.9%) and 33 patients on MIT (HbA1c 8.7 ± 1.3%) for 48 h. Occurrence and duration of nocturnal hypoglycaemia were assessed and using multivariate regression analysis, the association between HbA1c, diabetes duration, treatment type (CSII vs. MIT), fasting and bedtime blood glucose values, total daily insulin dose and mean nocturnal glucose concentrations, and hypoglycaemia occurrence and duration was investigated.
Results Nocturnal hypoglycaemia ≤ 3.9 mmol/l occurred in 33.3% of both the CSII‐ (8/24) and MIT‐treated patients (11/33). Mean (± sd; median, interquartile range) duration of hypoglycaemia ≤ 3.9 mmol/l was 78 (± 76; 57, 23–120) min per night for the CSII‐ and 98 (± 80; 81, 32–158) min per night for the MIT‐treated group. Multivariate regression analysis showed that bedtime glucose value had the strongest association with the occurrence (P = 0.026) and duration (P = 0.032) of nocturnal hypoglycaemia.
Conclusions Microdialysis continuous glucose monitoring has enabled more precise quantification of nocturnal hypoglycaemia occurrence and duration in Type 1 diabetic patients. Occurrence and duration of nocturnal hypoglycaemia were mainly associated with bedtime glucose value. |
| doi_str_mv | 10.1111/j.1464-5491.2007.02107.x |
| format | Article |
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Methods A microdialysis sensor was worn at home by 24 patients on CSII (mean HbA1c 7.8 ± 0.9%) and 33 patients on MIT (HbA1c 8.7 ± 1.3%) for 48 h. Occurrence and duration of nocturnal hypoglycaemia were assessed and using multivariate regression analysis, the association between HbA1c, diabetes duration, treatment type (CSII vs. MIT), fasting and bedtime blood glucose values, total daily insulin dose and mean nocturnal glucose concentrations, and hypoglycaemia occurrence and duration was investigated.
Results Nocturnal hypoglycaemia ≤ 3.9 mmol/l occurred in 33.3% of both the CSII‐ (8/24) and MIT‐treated patients (11/33). Mean (± sd; median, interquartile range) duration of hypoglycaemia ≤ 3.9 mmol/l was 78 (± 76; 57, 23–120) min per night for the CSII‐ and 98 (± 80; 81, 32–158) min per night for the MIT‐treated group. Multivariate regression analysis showed that bedtime glucose value had the strongest association with the occurrence (P = 0.026) and duration (P = 0.032) of nocturnal hypoglycaemia.
Conclusions Microdialysis continuous glucose monitoring has enabled more precise quantification of nocturnal hypoglycaemia occurrence and duration in Type 1 diabetic patients. Occurrence and duration of nocturnal hypoglycaemia were mainly associated with bedtime glucose value.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/j.1464-5491.2007.02107.x</identifier><identifier>PMID: 17381503</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Blood Glucose - analysis ; Blood Glucose Self-Monitoring - methods ; Circadian Rhythm ; continuous glucose monitoring ; continuous subcutaneous insulin infusion ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - complications ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Humans ; Hypoglycemia - blood ; Hypoglycemia - etiology ; Insulin - administration & dosage ; Male ; Medical sciences ; Middle Aged ; nocturnal hypoglycaemia ; Risk Factors ; Type 1 diabetes</subject><ispartof>Diabetic medicine, 2007-05, Vol.24 (5), p.527-532</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4357-28630b783b90f744ce08ce9d4c0192bf966b671a42254107c33f696edfa140ea3</citedby><cites>FETCH-LOGICAL-c4357-28630b783b90f744ce08ce9d4c0192bf966b671a42254107c33f696edfa140ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-5491.2007.02107.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-5491.2007.02107.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18711925$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17381503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wentholt, I. M. E.</creatorcontrib><creatorcontrib>Maran, A.</creatorcontrib><creatorcontrib>Masurel, N.</creatorcontrib><creatorcontrib>Heine, R. J.</creatorcontrib><creatorcontrib>Hoekstra, J. B. L.</creatorcontrib><creatorcontrib>DeVries, J. H.</creatorcontrib><title>Nocturnal hypoglycaemia in Type 1 diabetic patients, assessed with continuous glucose monitoring: frequency, duration and associations</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>Aims We quantified the occurrence and duration of nocturnal hypoglycaemia in individuals with Type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII) or multiple‐injection therapy (MIT) using a continuous subcutaneous glucose sensor.
Methods A microdialysis sensor was worn at home by 24 patients on CSII (mean HbA1c 7.8 ± 0.9%) and 33 patients on MIT (HbA1c 8.7 ± 1.3%) for 48 h. Occurrence and duration of nocturnal hypoglycaemia were assessed and using multivariate regression analysis, the association between HbA1c, diabetes duration, treatment type (CSII vs. MIT), fasting and bedtime blood glucose values, total daily insulin dose and mean nocturnal glucose concentrations, and hypoglycaemia occurrence and duration was investigated.
Results Nocturnal hypoglycaemia ≤ 3.9 mmol/l occurred in 33.3% of both the CSII‐ (8/24) and MIT‐treated patients (11/33). Mean (± sd; median, interquartile range) duration of hypoglycaemia ≤ 3.9 mmol/l was 78 (± 76; 57, 23–120) min per night for the CSII‐ and 98 (± 80; 81, 32–158) min per night for the MIT‐treated group. Multivariate regression analysis showed that bedtime glucose value had the strongest association with the occurrence (P = 0.026) and duration (P = 0.032) of nocturnal hypoglycaemia.
Conclusions Microdialysis continuous glucose monitoring has enabled more precise quantification of nocturnal hypoglycaemia occurrence and duration in Type 1 diabetic patients. Occurrence and duration of nocturnal hypoglycaemia were mainly associated with bedtime glucose value.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Blood Glucose Self-Monitoring - methods</subject><subject>Circadian Rhythm</subject><subject>continuous glucose monitoring</subject><subject>continuous subcutaneous insulin infusion</subject><subject>Diabetes Mellitus, Type 1 - blood</subject><subject>Diabetes Mellitus, Type 1 - complications</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Humans</subject><subject>Hypoglycemia - blood</subject><subject>Hypoglycemia - etiology</subject><subject>Insulin - administration & dosage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>nocturnal hypoglycaemia</subject><subject>Risk Factors</subject><subject>Type 1 diabetes</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhi0EokvLKyBf4NRs7diJEyQOqJRSadtKUATiYjnOZOslsYOdqJsn4DV4Fp4Mp7tqr1iWx5a_fzz-ByFMyZLGcbJZUp7zJOMlXaaEiCVJaVy3T9Di4eIpWhDB04QRQQ_QixA2hNC0ZOVzdEAFK2hG2AL9vnJ6GL1VLb6derduJ62gMwobi2-mHv7-obg2qoLBaNyrwYAdwjFWIUCcNb4zwy3Wzg7Gjm4MeN2O2gXAnbNmcN7Y9VvcePg1gtXTMa5HH3M4i5Wt5yROm_tzOELPGtUGeLmPh-jrx7Ob00_J6vr84vT9KtGcZSJJi5yRShSsKkkjONdACg1lzTWhZVo1ZZ5XuaCKp2nGoyWasSYvc6gbRTkBxQ7Rm13e3rtYVBhkZ4KGtlUWYv1SEJ4VaZlHsNiB2rsQPDSy96ZTfpKUyLkJciNnr-XstZybIO-bILdR-mr_xlh1UD8K965H4PUeUEGrtvHKahMeuULQ-Jsscu923J1pYfrvAuSHy7N5F_XJTm_CANsHvfI_ZS6YyOS3q3NZFF9W3z__yOQl-wedobT1</recordid><startdate>200705</startdate><enddate>200705</enddate><creator>Wentholt, I. M. E.</creator><creator>Maran, A.</creator><creator>Masurel, N.</creator><creator>Heine, R. J.</creator><creator>Hoekstra, J. B. L.</creator><creator>DeVries, J. H.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200705</creationdate><title>Nocturnal hypoglycaemia in Type 1 diabetic patients, assessed with continuous glucose monitoring: frequency, duration and associations</title><author>Wentholt, I. M. E. ; Maran, A. ; Masurel, N. ; Heine, R. J. ; Hoekstra, J. B. L. ; DeVries, J. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4357-28630b783b90f744ce08ce9d4c0192bf966b671a42254107c33f696edfa140ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Blood Glucose Self-Monitoring - methods</topic><topic>Circadian Rhythm</topic><topic>continuous glucose monitoring</topic><topic>continuous subcutaneous insulin infusion</topic><topic>Diabetes Mellitus, Type 1 - blood</topic><topic>Diabetes Mellitus, Type 1 - complications</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Humans</topic><topic>Hypoglycemia - blood</topic><topic>Hypoglycemia - etiology</topic><topic>Insulin - administration & dosage</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>nocturnal hypoglycaemia</topic><topic>Risk Factors</topic><topic>Type 1 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wentholt, I. M. E.</creatorcontrib><creatorcontrib>Maran, A.</creatorcontrib><creatorcontrib>Masurel, N.</creatorcontrib><creatorcontrib>Heine, R. J.</creatorcontrib><creatorcontrib>Hoekstra, J. B. L.</creatorcontrib><creatorcontrib>DeVries, J. H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wentholt, I. M. E.</au><au>Maran, A.</au><au>Masurel, N.</au><au>Heine, R. J.</au><au>Hoekstra, J. B. L.</au><au>DeVries, J. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nocturnal hypoglycaemia in Type 1 diabetic patients, assessed with continuous glucose monitoring: frequency, duration and associations</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2007-05</date><risdate>2007</risdate><volume>24</volume><issue>5</issue><spage>527</spage><epage>532</epage><pages>527-532</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>Aims We quantified the occurrence and duration of nocturnal hypoglycaemia in individuals with Type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII) or multiple‐injection therapy (MIT) using a continuous subcutaneous glucose sensor.
Methods A microdialysis sensor was worn at home by 24 patients on CSII (mean HbA1c 7.8 ± 0.9%) and 33 patients on MIT (HbA1c 8.7 ± 1.3%) for 48 h. Occurrence and duration of nocturnal hypoglycaemia were assessed and using multivariate regression analysis, the association between HbA1c, diabetes duration, treatment type (CSII vs. MIT), fasting and bedtime blood glucose values, total daily insulin dose and mean nocturnal glucose concentrations, and hypoglycaemia occurrence and duration was investigated.
Results Nocturnal hypoglycaemia ≤ 3.9 mmol/l occurred in 33.3% of both the CSII‐ (8/24) and MIT‐treated patients (11/33). Mean (± sd; median, interquartile range) duration of hypoglycaemia ≤ 3.9 mmol/l was 78 (± 76; 57, 23–120) min per night for the CSII‐ and 98 (± 80; 81, 32–158) min per night for the MIT‐treated group. Multivariate regression analysis showed that bedtime glucose value had the strongest association with the occurrence (P = 0.026) and duration (P = 0.032) of nocturnal hypoglycaemia.
Conclusions Microdialysis continuous glucose monitoring has enabled more precise quantification of nocturnal hypoglycaemia occurrence and duration in Type 1 diabetic patients. Occurrence and duration of nocturnal hypoglycaemia were mainly associated with bedtime glucose value.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17381503</pmid><doi>10.1111/j.1464-5491.2007.02107.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Diabetic medicine, 2007-05, Vol.24 (5), p.527-532 |
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| subjects | Adult Biological and medical sciences Blood Glucose - analysis Blood Glucose Self-Monitoring - methods Circadian Rhythm continuous glucose monitoring continuous subcutaneous insulin infusion Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Humans Hypoglycemia - blood Hypoglycemia - etiology Insulin - administration & dosage Male Medical sciences Middle Aged nocturnal hypoglycaemia Risk Factors Type 1 diabetes |
| title | Nocturnal hypoglycaemia in Type 1 diabetic patients, assessed with continuous glucose monitoring: frequency, duration and associations |
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