Synthesis of Isomeric, Oxathiolone Fused Chalcones, and Comparison of Their Activity toward Various Microorganisms and Human Cancer Cells Line

Isomeric oxathiolone fused chalcones were prepared by condensation of appropriate acetylbenzo[1,3]oxathiol-2-ones with benzaldehydes under acidic conditions. The synthesized compounds were screened for cytotoxic activity using HeLa cells, as well as for antibacterial activity against Micrococcus lut...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2007, Vol.55(5), pp.817-820
Hauptverfasser:	Konieczny, Marek Tadeusz, Konieczny, Wojciech, Sabisz, Michał, Skladanowski, Andrzej, Wakieć, Roland, Augustynowicz-Kopeć, Ewa, Zwolska, Zofia
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology antibacterial antifungal Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antitubercular Agents - chemical synthesis Antitubercular Agents - pharmacology Bridged Bicyclo Compounds, Heterocyclic - chemistry Bridged Bicyclo Compounds, Heterocyclic - pharmacology Candida albicans Cell Line, Tumor chalcone Chalcones - chemistry Chalcones - isolation & purification Chalcones - pharmacology cytostatic Drug Screening Assays, Antitumor Escherichia coli HeLa Cells Humans Isomerism Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Micrococcus luteus Mycobacterium kansasii Mycobacterium tuberculosis oxathiolone Proteus vulgaris Salmonella typhimurium Staphylococcus aureus Tetrazolium Salts Thiazoles tuberculostatic
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