Synthesis of Isomeric, Oxathiolone Fused Chalcones, and Comparison of Their Activity toward Various Microorganisms and Human Cancer Cells Line
Isomeric oxathiolone fused chalcones were prepared by condensation of appropriate acetylbenzo[1,3]oxathiol-2-ones with benzaldehydes under acidic conditions. The synthesized compounds were screened for cytotoxic activity using HeLa cells, as well as for antibacterial activity against Micrococcus lut...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2007, Vol.55(5), pp.817-820 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | Konieczny, Marek Tadeusz Konieczny, Wojciech Sabisz, Michał Skladanowski, Andrzej Wakieć, Roland Augustynowicz-Kopeć, Ewa Zwolska, Zofia |
| description | Isomeric oxathiolone fused chalcones were prepared by condensation of appropriate acetylbenzo[1,3]oxathiol-2-ones with benzaldehydes under acidic conditions. The synthesized compounds were screened for cytotoxic activity using HeLa cells, as well as for antibacterial activity against Micrococcus luteus, Staphylococcus aureus, Salmonella typhimurium, Escherichia coli, Proteus vulgaris, antifungal activity against Candida albicans, and tuberculostatic activity against Mycobacterium tuberculosis H37Rv and Mycobacterium kansasii strains. |
| doi_str_mv | 10.1248/cpb.55.817 |
| format | Article |
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Pharm. Bull.</addtitle><description>Isomeric oxathiolone fused chalcones were prepared by condensation of appropriate acetylbenzo[1,3]oxathiol-2-ones with benzaldehydes under acidic conditions. The synthesized compounds were screened for cytotoxic activity using HeLa cells, as well as for antibacterial activity against Micrococcus luteus, Staphylococcus aureus, Salmonella typhimurium, Escherichia coli, Proteus vulgaris, antifungal activity against Candida albicans, and tuberculostatic activity against Mycobacterium tuberculosis H37Rv and Mycobacterium kansasii strains.</description><subject>Anti-Infective Agents - chemical synthesis</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>antibacterial</subject><subject>antifungal</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antitubercular Agents - chemical synthesis</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Bridged Bicyclo Compounds, Heterocyclic - chemistry</subject><subject>Bridged Bicyclo Compounds, Heterocyclic - pharmacology</subject><subject>Candida albicans</subject><subject>Cell Line, Tumor</subject><subject>chalcone</subject><subject>Chalcones - chemistry</subject><subject>Chalcones - isolation & purification</subject><subject>Chalcones - pharmacology</subject><subject>cytostatic</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Escherichia coli</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Isomerism</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Microbial Sensitivity Tests</subject><subject>Micrococcus luteus</subject><subject>Mycobacterium kansasii</subject><subject>Mycobacterium tuberculosis</subject><subject>oxathiolone</subject><subject>Proteus vulgaris</subject><subject>Salmonella typhimurium</subject><subject>Staphylococcus aureus</subject><subject>Tetrazolium Salts</subject><subject>Thiazoles</subject><subject>tuberculostatic</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQhy0EokvhwgMgS0gcULPYjv-kp6qKKK20qAcKV2vieBuvEnuxHWBfgmfGyy5U4sLF1sjffBrPD6GXlCwp4807s-2WQiwbqh6hBa25qgRj9WO0IIScV6yW9Ql6ltKGECaIqp-iE6q4KlyzQD8_7XwebHIJhzW-SWGy0ZkzfPsD8uDCGLzFV3OyPW4HGE0p0xkGX8owbSG6FPy-8W6wLuJLk903l3c4h-8Qe_ylAGFO-KMzMYR4D96lKf1uv54n8LgFb2zErR3HhFfO2-foyRrGZF8c71P0-er9XXtdrW4_3LSXq8oIJnOlZAN9wxTppKTKUCEUp4LCWkBNBDHE9udM9kqyruG8kT3vKPRMWdpb4A2tT9Gbg3cbw9fZpqwnl0wZA7wtE2tFuJCN4v8FWdkxlXxvfP0PuAlz9OUTmnJJOCm-ulBvD1RZSErRrvU2ugniTlOi92HqEqYWQpcwC_zqqJy7yfYP6DG9AlwcgE3KcG__AhCzM6P94xKHoygfXgaI2vr6F-h8sSo</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Konieczny, Marek Tadeusz</creator><creator>Konieczny, Wojciech</creator><creator>Sabisz, Michał</creator><creator>Skladanowski, Andrzej</creator><creator>Wakieć, Roland</creator><creator>Augustynowicz-Kopeć, Ewa</creator><creator>Zwolska, Zofia</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Synthesis of Isomeric, Oxathiolone Fused Chalcones, and Comparison of Their Activity toward Various Microorganisms and Human Cancer Cells Line</title><author>Konieczny, Marek Tadeusz ; 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| ispartof | Chemical and Pharmaceutical Bulletin, 2007, Vol.55(5), pp.817-820 |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology antibacterial antifungal Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antitubercular Agents - chemical synthesis Antitubercular Agents - pharmacology Bridged Bicyclo Compounds, Heterocyclic - chemistry Bridged Bicyclo Compounds, Heterocyclic - pharmacology Candida albicans Cell Line, Tumor chalcone Chalcones - chemistry Chalcones - isolation & purification Chalcones - pharmacology cytostatic Drug Screening Assays, Antitumor Escherichia coli HeLa Cells Humans Isomerism Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Micrococcus luteus Mycobacterium kansasii Mycobacterium tuberculosis oxathiolone Proteus vulgaris Salmonella typhimurium Staphylococcus aureus Tetrazolium Salts Thiazoles tuberculostatic |
| title | Synthesis of Isomeric, Oxathiolone Fused Chalcones, and Comparison of Their Activity toward Various Microorganisms and Human Cancer Cells Line |
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