Porcine Endogenous Retrovirus Transmission Characteristics From a Designated Pathogen-Free Herd
Abstract Previously, a strategy for monitoring pigs intended for cell transplantation was developed and successfully applied to several representative herds in New Zealand. A better understanding of porcine viruses’ epidemiology in New Zealand has been achieved, and, as a result, a designated pathog...
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| Veröffentlicht in: | Transplantation proceedings 2008-03, Vol.40 (2), p.590-593 |
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| container_title | Transplantation proceedings |
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| creator | Garkavenko, O Wynyard, S Nathu, D Muzina, M Muzina, Z Scobie, L Hector, R.D Croxson, M.C Tan, P Elliott, B.R |
| description | Abstract Previously, a strategy for monitoring pigs intended for cell transplantation was developed and successfully applied to several representative herds in New Zealand. A better understanding of porcine viruses’ epidemiology in New Zealand has been achieved, and, as a result, a designated pathogen-free (DPF) herd has been chosen as a good candidate for xenotransplantation. This herd is free of all infectious agents relevant to xenotransplantation. The presented study of pig endogenous retrovirus (PERV) transmission with cocultures in vitro has shown no evidence of PERV transmission from DPF pig tissue. Additionally, in PERV-C–positive DPF donor pigs tested, a specific locus for PERV-C present in miniature swine possibly associated with the transmission of PERV was absent. The data on PERV transmission allowed classifying the DPF potential donors as “null” or noninfectious pigs. |
| doi_str_mv | 10.1016/j.transproceed.2008.01.051 |
| format | Article |
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A better understanding of porcine viruses’ epidemiology in New Zealand has been achieved, and, as a result, a designated pathogen-free (DPF) herd has been chosen as a good candidate for xenotransplantation. This herd is free of all infectious agents relevant to xenotransplantation. The presented study of pig endogenous retrovirus (PERV) transmission with cocultures in vitro has shown no evidence of PERV transmission from DPF pig tissue. Additionally, in PERV-C–positive DPF donor pigs tested, a specific locus for PERV-C present in miniature swine possibly associated with the transmission of PERV was absent. The data on PERV transmission allowed classifying the DPF potential donors as “null” or noninfectious pigs.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2008.01.051</identifier><identifier>PMID: 18374137</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animal Husbandry - standards ; Animals ; Biological and medical sciences ; Cell Count ; Cell Line ; Endogenous Retroviruses - genetics ; Endogenous Retroviruses - isolation & purification ; Endogenous Retroviruses - pathogenicity ; Fetus ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Kidney - embryology ; Kidney - virology ; Male ; Medical sciences ; New Zealand ; Retroviridae Infections - prevention & control ; Retroviridae Infections - transmission ; Reverse Transcriptase Polymerase Chain Reaction ; Safety ; Specific Pathogen-Free Organisms ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Swine ; Swine Diseases - virology ; Testis - embryology ; Testis - virology ; Tissue, organ and graft immunology ; Transplantation, Heterologous</subject><ispartof>Transplantation proceedings, 2008-03, Vol.40 (2), p.590-593</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-b71e51e536fb138f67bf6807292914461e3eb839cbf1df440bb8fa8769bd0ecb3</citedby><cites>FETCH-LOGICAL-c463t-b71e51e536fb138f67bf6807292914461e3eb839cbf1df440bb8fa8769bd0ecb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2008.01.051$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3541,23921,23922,25131,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20478453$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18374137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garkavenko, O</creatorcontrib><creatorcontrib>Wynyard, S</creatorcontrib><creatorcontrib>Nathu, D</creatorcontrib><creatorcontrib>Muzina, M</creatorcontrib><creatorcontrib>Muzina, Z</creatorcontrib><creatorcontrib>Scobie, L</creatorcontrib><creatorcontrib>Hector, R.D</creatorcontrib><creatorcontrib>Croxson, M.C</creatorcontrib><creatorcontrib>Tan, P</creatorcontrib><creatorcontrib>Elliott, B.R</creatorcontrib><title>Porcine Endogenous Retrovirus Transmission Characteristics From a Designated Pathogen-Free Herd</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract Previously, a strategy for monitoring pigs intended for cell transplantation was developed and successfully applied to several representative herds in New Zealand. A better understanding of porcine viruses’ epidemiology in New Zealand has been achieved, and, as a result, a designated pathogen-free (DPF) herd has been chosen as a good candidate for xenotransplantation. This herd is free of all infectious agents relevant to xenotransplantation. The presented study of pig endogenous retrovirus (PERV) transmission with cocultures in vitro has shown no evidence of PERV transmission from DPF pig tissue. Additionally, in PERV-C–positive DPF donor pigs tested, a specific locus for PERV-C present in miniature swine possibly associated with the transmission of PERV was absent. The data on PERV transmission allowed classifying the DPF potential donors as “null” or noninfectious pigs.</description><subject>Animal Husbandry - standards</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Count</subject><subject>Cell Line</subject><subject>Endogenous Retroviruses - genetics</subject><subject>Endogenous Retroviruses - isolation & purification</subject><subject>Endogenous Retroviruses - pathogenicity</subject><subject>Fetus</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Kidney - embryology</subject><subject>Kidney - virology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>New Zealand</subject><subject>Retroviridae Infections - prevention & control</subject><subject>Retroviridae Infections - transmission</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Safety</subject><subject>Specific Pathogen-Free Organisms</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Swine</subject><subject>Swine Diseases - virology</subject><subject>Testis - embryology</subject><subject>Testis - virology</subject><subject>Tissue, organ and graft immunology</subject><subject>Transplantation, Heterologous</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNklFrHCEUhaU0NNtt_0IZCu3bTHR01OlDoWyySSGQkKbPos6dxO2sJuoG8u_rsEsIfSoIKp57zvXjIvSZ4IZgwk82TY7ap4cYLMDQtBjLBpMGd-QNWhApaN3ylr5FC4wZqQll3TF6n9IGl3vL6Dt0TCQVjFCxQOo6ROs8VGd-CHfgwy5VN5BjeHKxHG_noK1LyQVfre511DZDdCk7m6p1DNtKV6eQ3J3XGYbqWuf72aVeR4DqAuLwAR2Nekrw8bAv0e_12e3qor68Ov-5-nFZW8Zpro0g0JVF-WgIlSMXZuQSi7Zve8IYJ0DBSNpbM5JhZAwbI0ctBe_NgMEaukRf976FyuMOUlalawvTpD2UPymBWcdnNkv0bS-0MaQUYVQP0W11fFYEqxmv2qjXeNWMV2GiCt5S_OmQsjPb8vZSeuBZBF8OAp2snsZiZF160bWYCck6WnSnex0UJk8OokrWgbcwuAg2qyG4_-vn-z82dnLeleQ_8AxpE3bRF-qKqNQqrH7NAzHPA5ZlFvpe0L_rx7Xf</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Garkavenko, O</creator><creator>Wynyard, S</creator><creator>Nathu, D</creator><creator>Muzina, M</creator><creator>Muzina, Z</creator><creator>Scobie, L</creator><creator>Hector, R.D</creator><creator>Croxson, M.C</creator><creator>Tan, P</creator><creator>Elliott, B.R</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080301</creationdate><title>Porcine Endogenous Retrovirus Transmission Characteristics From a Designated Pathogen-Free Herd</title><author>Garkavenko, O ; Wynyard, S ; Nathu, D ; Muzina, M ; Muzina, Z ; Scobie, L ; Hector, R.D ; Croxson, M.C ; Tan, P ; Elliott, B.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-b71e51e536fb138f67bf6807292914461e3eb839cbf1df440bb8fa8769bd0ecb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animal Husbandry - standards</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Count</topic><topic>Cell Line</topic><topic>Endogenous Retroviruses - genetics</topic><topic>Endogenous Retroviruses - isolation & purification</topic><topic>Endogenous Retroviruses - pathogenicity</topic><topic>Fetus</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Kidney - embryology</topic><topic>Kidney - virology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>New Zealand</topic><topic>Retroviridae Infections - prevention & control</topic><topic>Retroviridae Infections - transmission</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Safety</topic><topic>Specific Pathogen-Free Organisms</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Swine</topic><topic>Swine Diseases - virology</topic><topic>Testis - embryology</topic><topic>Testis - virology</topic><topic>Tissue, organ and graft immunology</topic><topic>Transplantation, Heterologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garkavenko, O</creatorcontrib><creatorcontrib>Wynyard, S</creatorcontrib><creatorcontrib>Nathu, D</creatorcontrib><creatorcontrib>Muzina, M</creatorcontrib><creatorcontrib>Muzina, Z</creatorcontrib><creatorcontrib>Scobie, L</creatorcontrib><creatorcontrib>Hector, R.D</creatorcontrib><creatorcontrib>Croxson, M.C</creatorcontrib><creatorcontrib>Tan, P</creatorcontrib><creatorcontrib>Elliott, B.R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garkavenko, O</au><au>Wynyard, S</au><au>Nathu, D</au><au>Muzina, M</au><au>Muzina, Z</au><au>Scobie, L</au><au>Hector, R.D</au><au>Croxson, M.C</au><au>Tan, P</au><au>Elliott, B.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Porcine Endogenous Retrovirus Transmission Characteristics From a Designated Pathogen-Free Herd</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>40</volume><issue>2</issue><spage>590</spage><epage>593</epage><pages>590-593</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Abstract Previously, a strategy for monitoring pigs intended for cell transplantation was developed and successfully applied to several representative herds in New Zealand. A better understanding of porcine viruses’ epidemiology in New Zealand has been achieved, and, as a result, a designated pathogen-free (DPF) herd has been chosen as a good candidate for xenotransplantation. This herd is free of all infectious agents relevant to xenotransplantation. The presented study of pig endogenous retrovirus (PERV) transmission with cocultures in vitro has shown no evidence of PERV transmission from DPF pig tissue. Additionally, in PERV-C–positive DPF donor pigs tested, a specific locus for PERV-C present in miniature swine possibly associated with the transmission of PERV was absent. The data on PERV transmission allowed classifying the DPF potential donors as “null” or noninfectious pigs.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18374137</pmid><doi>10.1016/j.transproceed.2008.01.051</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animal Husbandry - standards Animals Biological and medical sciences Cell Count Cell Line Endogenous Retroviruses - genetics Endogenous Retroviruses - isolation & purification Endogenous Retroviruses - pathogenicity Fetus Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Kidney - embryology Kidney - virology Male Medical sciences New Zealand Retroviridae Infections - prevention & control Retroviridae Infections - transmission Reverse Transcriptase Polymerase Chain Reaction Safety Specific Pathogen-Free Organisms Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Swine Swine Diseases - virology Testis - embryology Testis - virology Tissue, organ and graft immunology Transplantation, Heterologous |
| title | Porcine Endogenous Retrovirus Transmission Characteristics From a Designated Pathogen-Free Herd |
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