Opposing effects of glucocorticoids and Wnt signaling on Krox20 and mineral deposition in osteoblast cultures

Krox20 is expressed in osteoblasts and chondrocytes, and is required for trabecular bone formation during embryogenesis. Here we show by RT‐qPCR and Western blot analysis that Krox20 is up‐regulated during late stages of osteoblast differentiation in culture. Glucocorticoids (GCs) rapidly inhibit th...

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Veröffentlicht in:	Journal of cellular biochemistry 2008-04, Vol.103 (6), p.1938-1951
Hauptverfasser:	Leclerc, Nathalie, Noh, Tommy, Cogan, Jon, Samarawickrama, Dilan B., Smith, Elisheva, Frenkel, Baruch
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcification, Physiologic - drug effects Calcification, Physiologic - physiology Cell Differentiation Cell Line DNA-Binding Proteins - metabolism early growth response genes Early Growth Response Protein 2 - metabolism Gene Expression Regulation glucocorticoids Glucocorticoids - pharmacology Heat Shock Transcription Factors Krox20 Mice mineralization osteoblast Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - physiology Signal Transduction Transcription Factors - metabolism Wnt Proteins - physiology Wnt signaling Wnt3 Protein Wnt3A Protein
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