Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms

Abstract We previously demonstrated that peripherally located N -methyl- d -aspartic acid (NMDA) receptors contribute to acute muscle nociception and the development of chronic muscular hyperalgesia. In the present study, we investigated the potential role of peripheral group I metabotropic glutamat...

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Veröffentlicht in:	Neuroscience 2007-04, Vol.146 (1), p.375-383
Hauptverfasser:	Lee, J.-S, Ro, J.Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Area Under Curve Behavior, Animal behavioral model Biological and medical sciences Chromones - pharmacology Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology glutamate Hyperalgesia - drug therapy Hyperalgesia - pathology Male masseter Masseter Muscle - drug effects Masseter Muscle - physiopathology Methoxyhydroxyphenylglycol - analogs & derivatives Methoxyhydroxyphenylglycol - pharmacology Neurology Pain Threshold - drug effects Physical Stimulation - methods Protein Kinase C - metabolism Pyridines - pharmacology rat Rats Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - physiology Vertebrates: nervous system and sense organs
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