IL-4-induced Stat6 activities affect apoptosis and gene expression in breast cancer cells

IL-4-induced Stat6 signaling is active in a variety of cell types, including immune cells and cancer cells, and plays an important role in the regulation of gene expression. Using EMSA gel shift assay and an antibody to Stat6, we phenotyped two breast cancer cell lines, ZR-75-1 being active Stat6 hi...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2008-04, Vol.42 (1), p.39-47
Hauptverfasser:	Zhang, Wen Jie, Li, Ben Hui, Yang, Xian Zi, Li, Pin Dong, Yuan, Qin, Liu, Xiao Hong, Xu, Shuang Bing, Zhang, Yan, Yuan, Jia, Gerhard, Glenn S., Masker, Kathryn K., Dong, Cheng, Koltun, Walter A., Chorney, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - physiology Breast cancer Breast Neoplasms - metabolism Cell Line, Tumor Expression microarray Female Gene Expression Profiling Gene Expression Regulation Humans IL-4 Interleukin-4 - genetics Interleukin-4 - metabolism Molecular Sequence Data Neoplasm Metastasis Oligonucleotide Array Sequence Analysis Phenotype Reproducibility of Results Signal Transduction - physiology Stat6 STAT6 Transcription Factor - genetics STAT6 Transcription Factor - metabolism
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