Gastric cancer cells exploit CD4+ cell‐derived CCL5 for their growth and prevention of CD8+ cell‐involved tumor elimination

The level of serum CCL5, a C‐C chemokine, is reportedly correlated with tumor progression in several cancers. We herein investigated the mechanisms by which CCL5 might contribute to tumor progression in gastric cancer. Serum CCL5 levels significantly correlated with tumor progression and prognosis i...

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Veröffentlicht in:	International journal of cancer 2008-06, Vol.122 (11), p.2535-2541
Hauptverfasser:	Sugasawa, Hidekazu, Ichikura, Takashi, Kinoshita, Manabu, Ono, Satoshi, Majima, Takashi, Tsujimoto, Hironori, Chochi, Kentaro, Hiroi, Sadayuki, Takayama, Eiji, Saitoh, Daizoh, Seki, Shuhji, Mochizuki, Hidetaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals anti‐tumor immunity Apoptosis Biological and medical sciences Biomarkers, Tumor - blood CCL5 CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Cell Proliferation Chemokine CCL5 - blood Chemokine CCL5 - metabolism Coculture Techniques Disease Progression Fas Fas Ligand Protein - immunology fas Receptor - immunology Female gastric cancer Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Leukocytes, Mononuclear - immunology Lymphocytes, Tumor-Infiltrating Male Medical sciences Mice Mice, SCID Middle Aged Neoplasm Staging Predictive Value of Tests Prognosis Stomach Neoplasms - blood Stomach Neoplasms - immunology Stomach Neoplasms - mortality Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Tumors
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