FGFR2-Amplified Gastric Cancer Cell Lines Require FGFR2 and Erbb3 Signaling for Growth and Survival

We have identified a critical role for amplified FGFR2 in gastric cancer cell proliferation and survival. In a panel of gastric cancer cell lines, fibroblast growth factor receptor 2 (FGFR2) was overexpressed and tyrosine phosphorylated selectively in FGFR2-amplified cell lines KatoIII, Snu16, and O...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-04, Vol.68 (7), p.2340-2348
Hauptverfasser:	KUNII, Kaiko, DAVIS, Lenora, GORENSTEIN, Julie, HATCH, Harold, YASHIRO, Masakazu, DI BACCO, Alessandra, ELBI, Cem, LUTTERBACH, Bart
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis - drug effects Apoptosis - genetics Biological and medical sciences Cell Growth Processes - genetics Cell Line, Tumor Gastroenterology. Liver. Pancreas. Abdomen Gene Amplification Humans Medical sciences Pharmacology. Drug treatments Phosphorylation Pyrimidines - pharmacology Receptor, ErbB-3 - metabolism Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors Receptor, Fibroblast Growth Factor, Type 2 - biosynthesis Receptor, Fibroblast Growth Factor, Type 2 - genetics Receptor, Fibroblast Growth Factor, Type 2 - metabolism RNA, Small Interfering - genetics Signal Transduction Stomach Neoplasms - enzymology Stomach Neoplasms - genetics Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!