Inhibition of Nitric Oxide and Tumor Necrosis Factor-Alpha by Moutan Cortex in Activated Mouse Peritoneal Macrophages
Moutan cortex (MC) is one of the most widely used Oriental herbal medicines for treating inflammatory diseases. In this study, the effect of MC on lipopolysaccharide (LPS) and recombinant interferon-gamma (rIFN-γ)-induced production of nitric oxide (NO) and tumor necrosis factor (TNF)-alpha were exa...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2007, Vol.30(5), pp.912-916 |
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| creator | Chung, Hwan-Suck Kang, Moonkyu Cho, Chongwoon Parvez, Shoukat Park, Chong-heong Kim, Dongwoo Oh, Joonghwan Kim, Hongyeoul Shin, Minkyu Hong, Moochang Kim, Yangseok Bae, Hyunsu |
| description | Moutan cortex (MC) is one of the most widely used Oriental herbal medicines for treating inflammatory diseases. In this study, the effect of MC on lipopolysaccharide (LPS) and recombinant interferon-gamma (rIFN-γ)-induced production of nitric oxide (NO) and tumor necrosis factor (TNF)-alpha were examined using mouse peritoneal macrophages. MC inhibited the LPS/rIFN-γ-induced expression of inducible nitric oxide synthase (iNOS) and TNF-alpha release. To clarify the mechanism involved, the effect of MC on the activation of nuclear factor (NF)-kappaB was examined. The LPS/rIFN-γ-induced activation of NF-kappaB was almost completely blocked by MC at 0.5 mg/ml. These findings demonstrate that the inhibition of the LPS/rIFN-γ-induced production of NO and TNF-alpha by MC is due to the inhibition of NF-kappaB activation. |
| doi_str_mv | 10.1248/bpb.30.912 |
| format | Article |
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In this study, the effect of MC on lipopolysaccharide (LPS) and recombinant interferon-gamma (rIFN-γ)-induced production of nitric oxide (NO) and tumor necrosis factor (TNF)-alpha were examined using mouse peritoneal macrophages. MC inhibited the LPS/rIFN-γ-induced expression of inducible nitric oxide synthase (iNOS) and TNF-alpha release. To clarify the mechanism involved, the effect of MC on the activation of nuclear factor (NF)-kappaB was examined. The LPS/rIFN-γ-induced activation of NF-kappaB was almost completely blocked by MC at 0.5 mg/ml. These findings demonstrate that the inhibition of the LPS/rIFN-γ-induced production of NO and TNF-alpha by MC is due to the inhibition of NF-kappaB activation.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.30.912</identifier><identifier>PMID: 17473434</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; anti-inflammatory effect ; Blotting, Western ; Cell Nucleus - drug effects ; Cell Nucleus - enzymology ; Cell Nucleus - metabolism ; Cell Survival - drug effects ; Cells, Cultured ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal - pharmacology ; Interferon-gamma - pharmacology ; Lipopolysaccharides - pharmacology ; Macrophage Activation - drug effects ; Macrophages, Peritoneal - drug effects ; Macrophages, Peritoneal - enzymology ; Macrophages, Peritoneal - metabolism ; Mice ; Moutan cortex (MC) ; NF-kappa B - metabolism ; nitric oxide ; Nitric Oxide - antagonists & inhibitors ; Nitric Oxide Synthase Type II - antagonists & inhibitors ; Paeonia ; peritoneal macrophage ; Recombinant Proteins ; Tumor Necrosis Factor-alpha - antagonists & inhibitors ; tumor necrosis factor-α</subject><ispartof>Biological and Pharmaceutical Bulletin, 2007, Vol.30(5), pp.912-916</ispartof><rights>2007 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c714t-e761d279c96d605ca172ac40e659cf38968bc038f3d4a1780e4706cea6caace73</citedby><cites>FETCH-LOGICAL-c714t-e761d279c96d605ca172ac40e659cf38968bc038f3d4a1780e4706cea6caace73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17473434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Hwan-Suck</creatorcontrib><creatorcontrib>Kang, Moonkyu</creatorcontrib><creatorcontrib>Cho, Chongwoon</creatorcontrib><creatorcontrib>Parvez, Shoukat</creatorcontrib><creatorcontrib>Park, Chong-heong</creatorcontrib><creatorcontrib>Kim, Dongwoo</creatorcontrib><creatorcontrib>Oh, Joonghwan</creatorcontrib><creatorcontrib>Kim, Hongyeoul</creatorcontrib><creatorcontrib>Shin, Minkyu</creatorcontrib><creatorcontrib>Hong, Moochang</creatorcontrib><creatorcontrib>Kim, Yangseok</creatorcontrib><creatorcontrib>Bae, Hyunsu</creatorcontrib><creatorcontrib>dDepartment of Physiology</creatorcontrib><creatorcontrib>College of Oriental Medicine</creatorcontrib><creatorcontrib>bDepartment of Internal Medicine</creatorcontrib><creatorcontrib>eNIBGE</creatorcontrib><creatorcontrib>Kyung Hee University</creatorcontrib><creatorcontrib>Kyungwon University</creatorcontrib><creatorcontrib>aPurimed R&D Institute</creatorcontrib><creatorcontrib>cInstitute of Oriental Medicine</creatorcontrib><title>Inhibition of Nitric Oxide and Tumor Necrosis Factor-Alpha by Moutan Cortex in Activated Mouse Peritoneal Macrophages</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Moutan cortex (MC) is one of the most widely used Oriental herbal medicines for treating inflammatory diseases. In this study, the effect of MC on lipopolysaccharide (LPS) and recombinant interferon-gamma (rIFN-γ)-induced production of nitric oxide (NO) and tumor necrosis factor (TNF)-alpha were examined using mouse peritoneal macrophages. MC inhibited the LPS/rIFN-γ-induced expression of inducible nitric oxide synthase (iNOS) and TNF-alpha release. To clarify the mechanism involved, the effect of MC on the activation of nuclear factor (NF)-kappaB was examined. The LPS/rIFN-γ-induced activation of NF-kappaB was almost completely blocked by MC at 0.5 mg/ml. These findings demonstrate that the inhibition of the LPS/rIFN-γ-induced production of NO and TNF-alpha by MC is due to the inhibition of NF-kappaB activation.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>anti-inflammatory effect</subject><subject>Blotting, Western</subject><subject>Cell Nucleus - drug effects</subject><subject>Cell Nucleus - enzymology</subject><subject>Cell Nucleus - metabolism</subject><subject>Cell Survival - drug effects</subject><subject>Cells, Cultured</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Interferon-gamma - pharmacology</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Macrophage Activation - drug effects</subject><subject>Macrophages, Peritoneal - drug effects</subject><subject>Macrophages, Peritoneal - enzymology</subject><subject>Macrophages, Peritoneal - metabolism</subject><subject>Mice</subject><subject>Moutan cortex (MC)</subject><subject>NF-kappa B - metabolism</subject><subject>nitric oxide</subject><subject>Nitric Oxide - antagonists & inhibitors</subject><subject>Nitric Oxide Synthase Type II - antagonists & inhibitors</subject><subject>Paeonia</subject><subject>peritoneal macrophage</subject><subject>Recombinant Proteins</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><subject>tumor necrosis factor-α</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEQhlcIREPhwg9AlpA4IG0Yf-x6fUJR1C-pHxzK2fJ6J8TRxg62t2r_PY6SUokLl_Hhfead8bxV9ZHCnDLRfet3_ZzDXFH2qppRLmTdMNq8rmagaFe3tOlOqncpbQBAAuNvqxMqheSCi1k1Xfm16112wZOwIrcuR2fJ3aMbkBg_kPtpGyK5RRtDcomcG5tDrBfjbm1I_0RuwpSNJ8sQMz4S58nCZvdgMg57KSH5gdHl4NGM5MYUk9L3C9P76s3KjAk_HN_T6uf52f3ysr6-u7haLq5rK6nINcqWDkwqq9qhhcYaKpmxArBtlF3xTrVdb4F3Kz6IonWAQkJr0bTWGIuSn1ZfDr67GH5PmLLeumRxHI3Hsp6WIBreCPZfkAFTXClRwM__gJswRV8-oakQipdrM1qorwdqf7YUcaV30W1NfNIU9D4zXTLTHHTJrMCfjpZTv8XhBT2GVICzA1BUZ80Y_Og8vgy2SfYujKFsCVIDcIBGA6W65M_2pZWioar4fD_4bFIuKfwdZGJ2dsTnnZpD2fc-K3ZtokbP_wBHLb5i</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Chung, Hwan-Suck</creator><creator>Kang, Moonkyu</creator><creator>Cho, Chongwoon</creator><creator>Parvez, Shoukat</creator><creator>Park, Chong-heong</creator><creator>Kim, Dongwoo</creator><creator>Oh, Joonghwan</creator><creator>Kim, Hongyeoul</creator><creator>Shin, Minkyu</creator><creator>Hong, Moochang</creator><creator>Kim, Yangseok</creator><creator>Bae, Hyunsu</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Inhibition of Nitric Oxide and Tumor Necrosis Factor-Alpha by Moutan Cortex in Activated Mouse Peritoneal Macrophages</title><author>Chung, Hwan-Suck ; Kang, Moonkyu ; Cho, Chongwoon ; Parvez, Shoukat ; Park, Chong-heong ; Kim, Dongwoo ; Oh, Joonghwan ; Kim, Hongyeoul ; Shin, Minkyu ; Hong, Moochang ; Kim, Yangseok ; Bae, Hyunsu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c714t-e761d279c96d605ca172ac40e659cf38968bc038f3d4a1780e4706cea6caace73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>anti-inflammatory effect</topic><topic>Blotting, Western</topic><topic>Cell Nucleus - drug effects</topic><topic>Cell Nucleus - enzymology</topic><topic>Cell Nucleus - metabolism</topic><topic>Cell Survival - drug effects</topic><topic>Cells, Cultured</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Interferon-gamma - pharmacology</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Macrophage Activation - drug effects</topic><topic>Macrophages, Peritoneal - drug effects</topic><topic>Macrophages, Peritoneal - enzymology</topic><topic>Macrophages, Peritoneal - metabolism</topic><topic>Mice</topic><topic>Moutan cortex (MC)</topic><topic>NF-kappa B - metabolism</topic><topic>nitric oxide</topic><topic>Nitric Oxide - antagonists & inhibitors</topic><topic>Nitric Oxide Synthase Type II - antagonists & inhibitors</topic><topic>Paeonia</topic><topic>peritoneal macrophage</topic><topic>Recombinant Proteins</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><topic>tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Hwan-Suck</creatorcontrib><creatorcontrib>Kang, Moonkyu</creatorcontrib><creatorcontrib>Cho, Chongwoon</creatorcontrib><creatorcontrib>Parvez, Shoukat</creatorcontrib><creatorcontrib>Park, Chong-heong</creatorcontrib><creatorcontrib>Kim, Dongwoo</creatorcontrib><creatorcontrib>Oh, Joonghwan</creatorcontrib><creatorcontrib>Kim, Hongyeoul</creatorcontrib><creatorcontrib>Shin, Minkyu</creatorcontrib><creatorcontrib>Hong, Moochang</creatorcontrib><creatorcontrib>Kim, Yangseok</creatorcontrib><creatorcontrib>Bae, Hyunsu</creatorcontrib><creatorcontrib>dDepartment of Physiology</creatorcontrib><creatorcontrib>College of Oriental Medicine</creatorcontrib><creatorcontrib>bDepartment of Internal Medicine</creatorcontrib><creatorcontrib>eNIBGE</creatorcontrib><creatorcontrib>Kyung Hee University</creatorcontrib><creatorcontrib>Kyungwon University</creatorcontrib><creatorcontrib>aPurimed R&D Institute</creatorcontrib><creatorcontrib>cInstitute of Oriental Medicine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Immunology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Hwan-Suck</au><au>Kang, Moonkyu</au><au>Cho, Chongwoon</au><au>Parvez, Shoukat</au><au>Park, Chong-heong</au><au>Kim, Dongwoo</au><au>Oh, Joonghwan</au><au>Kim, Hongyeoul</au><au>Shin, Minkyu</au><au>Hong, Moochang</au><au>Kim, Yangseok</au><au>Bae, Hyunsu</au><aucorp>dDepartment of Physiology</aucorp><aucorp>College of Oriental Medicine</aucorp><aucorp>bDepartment of Internal Medicine</aucorp><aucorp>eNIBGE</aucorp><aucorp>Kyung Hee University</aucorp><aucorp>Kyungwon University</aucorp><aucorp>aPurimed R&D Institute</aucorp><aucorp>cInstitute of Oriental Medicine</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Nitric Oxide and Tumor Necrosis Factor-Alpha by Moutan Cortex in Activated Mouse Peritoneal Macrophages</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>30</volume><issue>5</issue><spage>912</spage><epage>916</epage><pages>912-916</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Moutan cortex (MC) is one of the most widely used Oriental herbal medicines for treating inflammatory diseases. In this study, the effect of MC on lipopolysaccharide (LPS) and recombinant interferon-gamma (rIFN-γ)-induced production of nitric oxide (NO) and tumor necrosis factor (TNF)-alpha were examined using mouse peritoneal macrophages. MC inhibited the LPS/rIFN-γ-induced expression of inducible nitric oxide synthase (iNOS) and TNF-alpha release. To clarify the mechanism involved, the effect of MC on the activation of nuclear factor (NF)-kappaB was examined. The LPS/rIFN-γ-induced activation of NF-kappaB was almost completely blocked by MC at 0.5 mg/ml. These findings demonstrate that the inhibition of the LPS/rIFN-γ-induced production of NO and TNF-alpha by MC is due to the inhibition of NF-kappaB activation.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>17473434</pmid><doi>10.1248/bpb.30.912</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology anti-inflammatory effect Blotting, Western Cell Nucleus - drug effects Cell Nucleus - enzymology Cell Nucleus - metabolism Cell Survival - drug effects Cells, Cultured Chromatography, High Pressure Liquid Drugs, Chinese Herbal - pharmacology Interferon-gamma - pharmacology Lipopolysaccharides - pharmacology Macrophage Activation - drug effects Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - enzymology Macrophages, Peritoneal - metabolism Mice Moutan cortex (MC) NF-kappa B - metabolism nitric oxide Nitric Oxide - antagonists & inhibitors Nitric Oxide Synthase Type II - antagonists & inhibitors Paeonia peritoneal macrophage Recombinant Proteins Tumor Necrosis Factor-alpha - antagonists & inhibitors tumor necrosis factor-α |
| title | Inhibition of Nitric Oxide and Tumor Necrosis Factor-Alpha by Moutan Cortex in Activated Mouse Peritoneal Macrophages |
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