Regulation by Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 of alpha-galactosylceramide-induced antimetastatic activity and Th1 and Th2 responses of NKT cells

Interaction of alpha-galactosylceramide (alpha-GalCer) presented by CD1d on dendritic cells (DCs) with the invariant TCR of NKT cells activates NKT cells. We have now investigated the role of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 (SHPS-1), a transmembrane protein...

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Veröffentlicht in:	Journal of Immunology 2007-05, Vol.178 (10), p.6164-6172
Hauptverfasser:	Okajo, Jun, Kaneko, Yoriaki, Murata, Yoji, Tomizawa, Takeshi, Okuzawa, Chie, Saito, Yasuyuki, Kaneko, Yuka, Ishikawa-Sekigami, Tomomi, Okazawa, Hideki, Ohnishi, Hiroshi, Matozaki, Takashi, Nojima, Yoshihisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD1 - biosynthesis Antigens, CD1 - genetics Antigens, CD1d CD11c Antigen - biosynthesis CD11c Antigen - genetics Cytotoxicity, Immunologic - genetics Dendritic Cells - immunology Dendritic Cells - metabolism Galactosylceramides - administration & dosage Killer Cells, Natural - enzymology Killer Cells, Natural - immunology Lung Neoplasms - genetics Lung Neoplasms - immunology Lung Neoplasms - prevention & control Lung Neoplasms - secondary Lymphocyte Activation - genetics Melanoma, Experimental - genetics Melanoma, Experimental - immunology Melanoma, Experimental - pathology Melanoma, Experimental - prevention & control Mice Mice, Inbred C57BL Mice, Knockout Receptors, Immunologic - biosynthesis Receptors, Immunologic - deficiency Receptors, Immunologic - genetics Receptors, Immunologic - physiology src Homology Domains - genetics src Homology Domains - immunology T-Lymphocyte Subsets - enzymology T-Lymphocyte Subsets - immunology Th1 Cells - enzymology Th1 Cells - immunology Th1 Cells - metabolism Th2 Cells - enzymology Th2 Cells - immunology Th2 Cells - metabolism
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