TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations

Frontotemporal dementia is accompanied by motor neuron disease (FTD + MND) in ∼10% of cases. There is accumulating evidence for a clinicopathological overlap between FTD and MND based on observations of familial aggregation and neuropathological findings of ubiquitin-positive neuronal cytoplasmatic...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2007-05, Vol.130 (5), p.1375-1385
Hauptverfasser:	Seelaar, Harro, Jurgen Schelhaas, H., Azmani, Asma, Küsters, Benno, Rosso, Sonia, Majoor-Krakauer, Danielle, de Rijik, Maarten C., Rizzu, Patrizia, ten Brummelhuis, Ming, van Doorn, Pieter A., Kamphorst, Wouter, Willemsen, Rob, van Swieten, John C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - analysis Adult Biological and medical sciences Brain Chemistry Cohort Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia DNA-Binding Proteins - analysis Female Genotype Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus - chemistry Humans Immunohistochemistry Intercellular Signaling Peptides and Proteins - genetics Male Medical sciences Middle Aged Motor Neuron Disease - complications Motor Neuron Disease - genetics Motor Neuron Disease - metabolism Motor Neurons - chemistry Mutation Neocortex - chemistry Nervous system (semeiology, syndromes) Neurology Pedigree Pick Disease of the Brain - complications Pick Disease of the Brain - genetics Pick Disease of the Brain - metabolism RNA-Binding Proteins Sequestosome-1 Protein Ubiquitin - analysis
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