Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit

Bergaptol and geranylcoumarin were isolated from grapefruit and characterized using MS and NMR studies. Both the compounds were tested for their radical scavenging property using ABTS and DPPH methods. Bergaptol showed very good antioxidant potential and geranylcoumarin showed least activity. Furthe...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2007-06, Vol.15 (11), p.3684-3691
Hauptverfasser:	Girennavar, Basavaraj, Jayaprakasha, G.K., Jadegoud, Y., Nagana Gowda, G.A., Patil, Bhimanagouda S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidant activity Beverages Biological and medical sciences Citrus paradisi - chemistry Coumarin Coumarins - isolation & purification Coumarins - pharmacology CYP3A4 Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme Inhibitors Diterpenes - isolation & purification Diterpenes - pharmacology Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Free Radical Scavengers - isolation & purification Free Radical Scavengers - pharmacology Furocoumarin Furocoumarins - isolation & purification Furocoumarins - pharmacology General pharmacology Grapefruit juice–drug interaction Humans Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments
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