New Constituent from Podocarpus macrophyllus var. macrophyllus Shows Anti-tyrosinase Effect and Regulates Tyrosinase-Related Proteins and mRNA in Human Epidermal Melanocytes

A new biflavonoid, 2,3-dihydro-4′,4′′′-di-O-methylamentoflavone (5), and five known compounds, (−)-catechin (1), quercetin (2), 2,3-dihydrosciadopitysin (3), sciadopitysin (4), and isoginkgetin (6), were isolated from Podocarpus macrophyllus var. macrophyllus (Podocarpaceae). These compounds were ev...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2007, Vol.55(5), pp.757-761
Hauptverfasser:	Cheng, Kur-Ta, Hsu, Feng-Lin, Chen, Shih-Hui, Hsieh, Peng-Ke, Huang, Hsu-Shan, Lee, Ching-Kuo, Lee, Mei-Hsien
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3-dihydro-4′,4′′′-di-O-methylamentoflavone Blotting, Western Cell Line Cell Survival - drug effects DNA Primers Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Epidermal Cells Epidermis - drug effects Epidermis - metabolism human epidermal melanocyte Humans Magnetic Resonance Spectroscopy Melanins - metabolism Melanocytes - drug effects Melanocytes - enzymology Monophenol Monooxygenase - antagonists & inhibitors Monophenol Monooxygenase - biosynthesis Plant Extracts - chemistry Plants, Medicinal - chemistry Podocarpaceae Podocarpus macrophyllus quantitative real-time PCR Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Ultraviolet Tetrazolium Salts Thiazoles tyrosinase tyrosinase-related protein-2
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