Unveiling a Glycation Hot Spot in a Recombinant Humanized Monoclonal Antibody

Biotechnological companies and regulatory agencies are pursuing the complete characterization of protein therapeutics in every detail as a means to mitigate risks of product quality related safety issues. During the characterization of a recombinant humanized monoclonal antibody (referred to as rhuM...

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Veröffentlicht in:	Analytical chemistry (Washington) 2008-04, Vol.80 (7), p.2379-2390
Hauptverfasser:	Zhang, Boyan, Yang, Yi, Yuk, Inn, Pai, Roger, McKay, Patrick, Eigenbrot, Charles, Dennis, Mark, Katta, Viswanatham, Francissen, Kathleen Champion
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical chemistry Antibodies, immunoglobulins Antibodies, Monoclonal - analysis Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Biochemistry Biological and medical sciences Chemistry Chromatographic methods and physical methods associated with chromatography Exact sciences and technology Fundamental and applied biological sciences. Psychology Fundamental immunology Glycosylation Humans Immune system Mass Spectrometry Models, Molecular Molecular immunology Molecular Sequence Data Monoclonal antibodies Other chromatographic methods Protein Structure, Quaternary Proteins Recombinant Proteins - analysis Recombinant Proteins - chemistry Recombinant Proteins - immunology Spectrometric and optical methods
Online-Zugang:	Volltext
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