Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations
Coronary artery disease (CAD) has become a major health problem in many countries. Recent genome-wide association studies have identified the association between rs1333049 on chromosome 9p21 and susceptibility to CAD in Caucasoid populations. In this study, we evaluated the associations of rs1333049...
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| Veröffentlicht in: | Journal of human genetics 2008-04, Vol.53 (4), p.357-359 |
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| creator | Hinohara, Kunihiko Nakajima, Toshiaki Takahashi, Megumi Hohda, Shigeru Sasaoka, Taishi Nakahara, Ken-ichi Chida, Kouji Sawabe, Motoji Arimura, Takuro Sato, Akinori Lee, Bok-Soo Ban, Ji-min Yasunami, Michio Park, Jeong-Euy Izumi, Toru Kimura, Akinori |
| description | Coronary artery disease (CAD) has become a major health problem in many countries. Recent genome-wide association studies have identified the association between rs1333049 on chromosome 9p21 and susceptibility to CAD in Caucasoid populations. In this study, we evaluated the associations of rs1333049 with CAD in Japanese (604 patients and 1,151 controls) and Koreans (679 patients and 706 controls). We found a significant association in both Japanese [odds ratio (OR) = 1.30, 95% confidence interval (CI); 1.13–1.49,
p
= 0.00027, allele count model] and Koreans (OR = 1.19, 95% CI; 1.02–1.38,
p
= 0.025, allele count model). These observations demonstrated that chromosome 9p21 was the susceptibility locus for CAD also in East Asians. |
| doi_str_mv | 10.1007/s10038-008-0248-4 |
| format | Article |
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p
= 0.00027, allele count model] and Koreans (OR = 1.19, 95% CI; 1.02–1.38,
p
= 0.025, allele count model). These observations demonstrated that chromosome 9p21 was the susceptibility locus for CAD also in East Asians.</description><identifier>ISSN: 1434-5161</identifier><identifier>EISSN: 1435-232X</identifier><identifier>DOI: 10.1007/s10038-008-0248-4</identifier><identifier>PMID: 18264662</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Alleles ; Asian Continental Ancestry Group - genetics ; Biomedicine ; Cardiovascular disease ; Chromosome 9 ; Chromosomes ; Chromosomes, Human, Pair 9 - genetics ; Coronary artery ; Coronary Artery Disease - genetics ; Coronary vessels ; DNA Primers - genetics ; Gene Expression ; Gene Function ; Gene Therapy ; Genetic Predisposition to Disease - genetics ; Genome-wide association studies ; Genomes ; Heart diseases ; Human Genetics ; Humans ; Japan ; Korea ; Molecular Medicine ; Odds Ratio ; Polymorphism, Genetic ; Population studies ; Short Communication ; Statistics, Nonparametric ; Susceptibility</subject><ispartof>Journal of human genetics, 2008-04, Vol.53 (4), p.357-359</ispartof><rights>The Japan Society of Human Genetics and Springer 2008</rights><rights>The Japan Society of Human Genetics and Springer 2008.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-eb6dabad8c3d5411978f5705d8b51536871d8d22b88ff8c122deac8ce45515db3</citedby><cites>FETCH-LOGICAL-c528t-eb6dabad8c3d5411978f5705d8b51536871d8d22b88ff8c122deac8ce45515db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10038-008-0248-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10038-008-0248-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18264662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hinohara, Kunihiko</creatorcontrib><creatorcontrib>Nakajima, Toshiaki</creatorcontrib><creatorcontrib>Takahashi, Megumi</creatorcontrib><creatorcontrib>Hohda, Shigeru</creatorcontrib><creatorcontrib>Sasaoka, Taishi</creatorcontrib><creatorcontrib>Nakahara, Ken-ichi</creatorcontrib><creatorcontrib>Chida, Kouji</creatorcontrib><creatorcontrib>Sawabe, Motoji</creatorcontrib><creatorcontrib>Arimura, Takuro</creatorcontrib><creatorcontrib>Sato, Akinori</creatorcontrib><creatorcontrib>Lee, Bok-Soo</creatorcontrib><creatorcontrib>Ban, Ji-min</creatorcontrib><creatorcontrib>Yasunami, Michio</creatorcontrib><creatorcontrib>Park, Jeong-Euy</creatorcontrib><creatorcontrib>Izumi, Toru</creatorcontrib><creatorcontrib>Kimura, Akinori</creatorcontrib><title>Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations</title><title>Journal of human genetics</title><addtitle>J Hum Genet</addtitle><addtitle>J Hum Genet</addtitle><description>Coronary artery disease (CAD) has become a major health problem in many countries. Recent genome-wide association studies have identified the association between rs1333049 on chromosome 9p21 and susceptibility to CAD in Caucasoid populations. In this study, we evaluated the associations of rs1333049 with CAD in Japanese (604 patients and 1,151 controls) and Koreans (679 patients and 706 controls). We found a significant association in both Japanese [odds ratio (OR) = 1.30, 95% confidence interval (CI); 1.13–1.49,
p
= 0.00027, allele count model] and Koreans (OR = 1.19, 95% CI; 1.02–1.38,
p
= 0.025, allele count model). These observations demonstrated that chromosome 9p21 was the susceptibility locus for CAD also in East Asians.</description><subject>Alleles</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biomedicine</subject><subject>Cardiovascular disease</subject><subject>Chromosome 9</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 9 - genetics</subject><subject>Coronary artery</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary vessels</subject><subject>DNA Primers - genetics</subject><subject>Gene Expression</subject><subject>Gene Function</subject><subject>Gene Therapy</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genome-wide association studies</subject><subject>Genomes</subject><subject>Heart diseases</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Japan</subject><subject>Korea</subject><subject>Molecular Medicine</subject><subject>Odds Ratio</subject><subject>Polymorphism, Genetic</subject><subject>Population studies</subject><subject>Short Communication</subject><subject>Statistics, Nonparametric</subject><subject>Susceptibility</subject><issn>1434-5161</issn><issn>1435-232X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc1q3TAQhUVpaNK0D9BNERS6cyuNJVt3WUL6GyiEFLoTsjTudbAlV2NTss-DVze-ECh0Ic2g-ebMoMPYKyneSSHa91Tu2lRClAPKVOoJO5Oq1hXU8PPpQ64qLRt5yp4T3YpCQwvP2Kk00KimgTN2f43zOHi3DCny1PNlj9wRJT9sTx0ufxAjd9zvc5oSpQn5bgbJ5zTeTSnP-4Em7mLgPuUUXb7jLi9YQhgIHSEfIv_qZhex5AfuW8roYumf1_FhCL1gJ70bCV8e4zn78fHy5uJzdfX905eLD1eV12CWCrsmuM4F4-uglZS71vS6FTqYTktdN6aVwQSAzpi-N14CBHTeeFS61ENXn7O3m-6c0-8VabHTQB7HsSyXVrKtUFqonSrgm3_A27TmWHazoEA30hgQhZIb5XMiytjbOQ9T-QErhT0YZDeDbDHIHgyyB-XXR-W1mzA8dhwdKQBsAJVS_IX5cfT_Vf8CzcudRA</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Hinohara, Kunihiko</creator><creator>Nakajima, Toshiaki</creator><creator>Takahashi, Megumi</creator><creator>Hohda, Shigeru</creator><creator>Sasaoka, Taishi</creator><creator>Nakahara, Ken-ichi</creator><creator>Chida, Kouji</creator><creator>Sawabe, Motoji</creator><creator>Arimura, Takuro</creator><creator>Sato, Akinori</creator><creator>Lee, Bok-Soo</creator><creator>Ban, Ji-min</creator><creator>Yasunami, Michio</creator><creator>Park, Jeong-Euy</creator><creator>Izumi, Toru</creator><creator>Kimura, Akinori</creator><general>Springer Japan</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations</title><author>Hinohara, Kunihiko ; Nakajima, Toshiaki ; Takahashi, Megumi ; Hohda, Shigeru ; Sasaoka, Taishi ; Nakahara, Ken-ichi ; Chida, Kouji ; Sawabe, Motoji ; Arimura, Takuro ; Sato, Akinori ; Lee, Bok-Soo ; Ban, Ji-min ; Yasunami, Michio ; Park, Jeong-Euy ; Izumi, Toru ; Kimura, Akinori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-eb6dabad8c3d5411978f5705d8b51536871d8d22b88ff8c122deac8ce45515db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Alleles</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biomedicine</topic><topic>Cardiovascular disease</topic><topic>Chromosome 9</topic><topic>Chromosomes</topic><topic>Chromosomes, Human, Pair 9 - genetics</topic><topic>Coronary artery</topic><topic>Coronary Artery Disease - genetics</topic><topic>Coronary vessels</topic><topic>DNA Primers - genetics</topic><topic>Gene Expression</topic><topic>Gene Function</topic><topic>Gene Therapy</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genome-wide association studies</topic><topic>Genomes</topic><topic>Heart diseases</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Japan</topic><topic>Korea</topic><topic>Molecular Medicine</topic><topic>Odds Ratio</topic><topic>Polymorphism, Genetic</topic><topic>Population studies</topic><topic>Short Communication</topic><topic>Statistics, Nonparametric</topic><topic>Susceptibility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hinohara, Kunihiko</creatorcontrib><creatorcontrib>Nakajima, Toshiaki</creatorcontrib><creatorcontrib>Takahashi, Megumi</creatorcontrib><creatorcontrib>Hohda, Shigeru</creatorcontrib><creatorcontrib>Sasaoka, Taishi</creatorcontrib><creatorcontrib>Nakahara, Ken-ichi</creatorcontrib><creatorcontrib>Chida, Kouji</creatorcontrib><creatorcontrib>Sawabe, Motoji</creatorcontrib><creatorcontrib>Arimura, Takuro</creatorcontrib><creatorcontrib>Sato, Akinori</creatorcontrib><creatorcontrib>Lee, Bok-Soo</creatorcontrib><creatorcontrib>Ban, Ji-min</creatorcontrib><creatorcontrib>Yasunami, Michio</creatorcontrib><creatorcontrib>Park, Jeong-Euy</creatorcontrib><creatorcontrib>Izumi, Toru</creatorcontrib><creatorcontrib>Kimura, Akinori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hinohara, Kunihiko</au><au>Nakajima, Toshiaki</au><au>Takahashi, Megumi</au><au>Hohda, Shigeru</au><au>Sasaoka, Taishi</au><au>Nakahara, Ken-ichi</au><au>Chida, Kouji</au><au>Sawabe, Motoji</au><au>Arimura, Takuro</au><au>Sato, Akinori</au><au>Lee, Bok-Soo</au><au>Ban, Ji-min</au><au>Yasunami, Michio</au><au>Park, Jeong-Euy</au><au>Izumi, Toru</au><au>Kimura, Akinori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations</atitle><jtitle>Journal of human genetics</jtitle><stitle>J Hum Genet</stitle><addtitle>J Hum Genet</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>53</volume><issue>4</issue><spage>357</spage><epage>359</epage><pages>357-359</pages><issn>1434-5161</issn><eissn>1435-232X</eissn><abstract>Coronary artery disease (CAD) has become a major health problem in many countries. Recent genome-wide association studies have identified the association between rs1333049 on chromosome 9p21 and susceptibility to CAD in Caucasoid populations. In this study, we evaluated the associations of rs1333049 with CAD in Japanese (604 patients and 1,151 controls) and Koreans (679 patients and 706 controls). We found a significant association in both Japanese [odds ratio (OR) = 1.30, 95% confidence interval (CI); 1.13–1.49,
p
= 0.00027, allele count model] and Koreans (OR = 1.19, 95% CI; 1.02–1.38,
p
= 0.025, allele count model). These observations demonstrated that chromosome 9p21 was the susceptibility locus for CAD also in East Asians.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>18264662</pmid><doi>10.1007/s10038-008-0248-4</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alleles Asian Continental Ancestry Group - genetics Biomedicine Cardiovascular disease Chromosome 9 Chromosomes Chromosomes, Human, Pair 9 - genetics Coronary artery Coronary Artery Disease - genetics Coronary vessels DNA Primers - genetics Gene Expression Gene Function Gene Therapy Genetic Predisposition to Disease - genetics Genome-wide association studies Genomes Heart diseases Human Genetics Humans Japan Korea Molecular Medicine Odds Ratio Polymorphism, Genetic Population studies Short Communication Statistics, Nonparametric Susceptibility |
| title | Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations |
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