EWS-FLI-1 Expression Triggers a Ewing's Sarcoma Initiation Program in Primary Human Mesenchymal Stem Cells

Ewing's sarcoma family tumors (ESFT) express the EWS-FLI-1 fusion gene generated by the chromosomal translocation t(11;22)(q24;q12). Expression of the EWS-FLI-1 fusion protein in a permissive cellular environment is believed to play a key role in ESFT pathogenesis. However, EWS-FLI-1 induces gr...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-04, Vol.68 (7), p.2176-2185
Hauptverfasser:	RIGGI, Nicolo, SUVA, Mario-Luca, STAMENKOVIC, Ivan, SUVA, Domizio, CIRONI, Luisa, PROVERO, Paolo, TERCIER, Stéphane, JOSEPH, Jean-Marc, STEHLE, Jean-Christophe, BAUMER, Karine, KINDLER, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell Differentiation - physiology Diseases of the osteoarticular system Enhancer of Zeste Homolog 2 Protein Gene Expression Profiling Gene Expression Regulation, Neoplastic - genetics Histone-Lysine N-Methyltransferase Humans Immunocompromised Host Medical sciences Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - pathology Mice Oncogene Proteins, Fusion - biosynthesis Oncogene Proteins, Fusion - genetics Pharmacology. Drug treatments Phenotype Polycomb Repressive Complex 2 Proteins - genetics Proto-Oncogene Protein c-fli-1 - biosynthesis Proto-Oncogene Protein c-fli-1 - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA-Binding Protein EWS Sarcoma, Ewing - genetics Sarcoma, Ewing - metabolism Sarcoma, Ewing - pathology Soft Tissue Neoplasms - genetics Soft Tissue Neoplasms - metabolism Soft Tissue Neoplasms - pathology Tumors Tumors of striated muscle and skeleton
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