Advances in esophageal cancer surgery in Japan: An analysis of 1000 consecutive patients treated at a single institute
Background In Japan, most esophageal cancers are squamous cell carcinomas, and the results of esophagectomy have improved remarkably in recent years. The object of this study was to evaluate advances in operative therapy for esophageal cancer in Japan. Method We evaluated mortality, morbidity, and p...
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| Veröffentlicht in: | Surgery 2008-04, Vol.143 (4), p.499-508 |
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| creator | Morita, Masaru, MD, PhD, FACS Yoshida, Rintaro, MD Ikeda, Keisuke, MD Egashira, Akinori, MD, PhD Oki, Eiji, MD PhD Sadanaga, Noriaki, MD, PhD Kakeji, Yoshihiro, MD, PhD, FACS Yamanaka, Takeharu, PhD Maehara, Yoshihiko, MD, PhD, FACS |
| description | Background In Japan, most esophageal cancers are squamous cell carcinomas, and the results of esophagectomy have improved remarkably in recent years. The object of this study was to evaluate advances in operative therapy for esophageal cancer in Japan. Method We evaluated mortality, morbidity, and prognosis in 1000 consecutive patients who underwent esophagectomy for esophageal cancer at a single institution in Japan. The patients were divided into 3 groups according to the period when esophagectomy was performed: Group I (n = 197), 1964–1980; group II (n = 432), 1981–1993; and group III (n = 371), 1993–2006. Results The incidence of squamous cell carcinoma was 94%. The morbidity rates were 62%, 38%, and 33 %, in groups I, II, and III, respectively ( P < 0.01, groups I vs II and III), and the in-hospital mortality rates were 14.2%, 5.1%, and 2.4%, respectively ( P < 0.01, between each group). The 5-year overall survival rate was 30% (14%, 27%, and 46% in groups I, II, and III, respectively; P |
| doi_str_mv | 10.1016/j.surg.2007.12.007 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70449340</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S003960600800086X</els_id><sourcerecordid>70449340</sourcerecordid><originalsourceid>FETCH-LOGICAL-c505t-d2a6c0024ae13cee5e7945e80ebff50efa30efe5484131c636509a1c6ea985f23</originalsourceid><addsrcrecordid>eNp9kl2r1DAQhosonvXoH_BCcqN3rZMm6YeIsBz85IAXKngX5qTTNWu3rZl0Yf-9KbsoeOFNJiTP-054J1n2VEIhQVYv9wUvYVeUAHUhyyKVe9lGGlXmtark_WwDoNq8ggquskfMewBotWweZleyUbUGXW-y47Y74uiIhR8F8TT_wB3hINx6GMTagMJpvfyEM46vxHYUOOJwYs9i6oVMpsJNI5Nboj-SmDF6GiOLGAgjdQKjQMF-3A2UbDj6uER6nD3ocWB6cqnX2bd3b7_efMhvP7__eLO9zZ0BE_OuxMoBlBpJKkdkqG61oQboru8NUI8qLWR0o6WSrlKVgRbThrBtTF-q6-zF2XcO06-FONqDZ0fDgCNNC9satG6VhgSWZ9CFiTlQb-fgDxhOVoJd07Z7u4Zh17StLG0qSfTs4r7cHaj7K7nEm4DnFwDZ4dCHlKrnP1wJpal1YxL3-sxRyuLoKVh2KUVHnQ_kou0m__93vPlH7gY_-tTxJ52I99MS0sjYSstJYL-s_2L9FtCk6TXVd_UbcAWzbw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70449340</pqid></control><display><type>article</type><title>Advances in esophageal cancer surgery in Japan: An analysis of 1000 consecutive patients treated at a single institute</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Morita, Masaru, MD, PhD, FACS ; Yoshida, Rintaro, MD ; Ikeda, Keisuke, MD ; Egashira, Akinori, MD, PhD ; Oki, Eiji, MD PhD ; Sadanaga, Noriaki, MD, PhD ; Kakeji, Yoshihiro, MD, PhD, FACS ; Yamanaka, Takeharu, PhD ; Maehara, Yoshihiko, MD, PhD, FACS</creator><creatorcontrib>Morita, Masaru, MD, PhD, FACS ; Yoshida, Rintaro, MD ; Ikeda, Keisuke, MD ; Egashira, Akinori, MD, PhD ; Oki, Eiji, MD PhD ; Sadanaga, Noriaki, MD, PhD ; Kakeji, Yoshihiro, MD, PhD, FACS ; Yamanaka, Takeharu, PhD ; Maehara, Yoshihiko, MD, PhD, FACS</creatorcontrib><description>Background In Japan, most esophageal cancers are squamous cell carcinomas, and the results of esophagectomy have improved remarkably in recent years. The object of this study was to evaluate advances in operative therapy for esophageal cancer in Japan. Method We evaluated mortality, morbidity, and prognosis in 1000 consecutive patients who underwent esophagectomy for esophageal cancer at a single institution in Japan. The patients were divided into 3 groups according to the period when esophagectomy was performed: Group I (n = 197), 1964–1980; group II (n = 432), 1981–1993; and group III (n = 371), 1993–2006. Results The incidence of squamous cell carcinoma was 94%. The morbidity rates were 62%, 38%, and 33 %, in groups I, II, and III, respectively ( P < 0.01, groups I vs II and III), and the in-hospital mortality rates were 14.2%, 5.1%, and 2.4%, respectively ( P < 0.01, between each group). The 5-year overall survival rate was 30% (14%, 27%, and 46% in groups I, II, and III, respectively; P < 0.0001). Multivariate analysis revealed age, gender, depth of invasion, node metastasis, distant metastasis, curability, extent of lymphadenectomy, resectability, and the period when the operation was performed as independent prognostic factors. Conclusion Generally, esophagectomy has been performed safely without critical complications; however, the prognosis has improved remarkably with advances in surgical techniques and treatment modalities.</description><identifier>ISSN: 0039-6060</identifier><identifier>EISSN: 1532-7361</identifier><identifier>DOI: 10.1016/j.surg.2007.12.007</identifier><identifier>PMID: 18374047</identifier><identifier>CODEN: SURGAZ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adenocarcinoma - surgery ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Squamous Cell - surgery ; Esophageal Neoplasms - surgery ; Esophagectomy - adverse effects ; Esophagectomy - statistics & numerical data ; Esophagectomy - trends ; Esophagus ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Humans ; Japan ; Male ; Medical sciences ; Middle Aged ; Prognosis ; Surgery ; Survival Analysis ; Tumors</subject><ispartof>Surgery, 2008-04, Vol.143 (4), p.499-508</ispartof><rights>Mosby, Inc.</rights><rights>2008 Mosby, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-d2a6c0024ae13cee5e7945e80ebff50efa30efe5484131c636509a1c6ea985f23</citedby><cites>FETCH-LOGICAL-c505t-d2a6c0024ae13cee5e7945e80ebff50efa30efe5484131c636509a1c6ea985f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S003960600800086X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20257485$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18374047$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morita, Masaru, MD, PhD, FACS</creatorcontrib><creatorcontrib>Yoshida, Rintaro, MD</creatorcontrib><creatorcontrib>Ikeda, Keisuke, MD</creatorcontrib><creatorcontrib>Egashira, Akinori, MD, PhD</creatorcontrib><creatorcontrib>Oki, Eiji, MD PhD</creatorcontrib><creatorcontrib>Sadanaga, Noriaki, MD, PhD</creatorcontrib><creatorcontrib>Kakeji, Yoshihiro, MD, PhD, FACS</creatorcontrib><creatorcontrib>Yamanaka, Takeharu, PhD</creatorcontrib><creatorcontrib>Maehara, Yoshihiko, MD, PhD, FACS</creatorcontrib><title>Advances in esophageal cancer surgery in Japan: An analysis of 1000 consecutive patients treated at a single institute</title><title>Surgery</title><addtitle>Surgery</addtitle><description>Background In Japan, most esophageal cancers are squamous cell carcinomas, and the results of esophagectomy have improved remarkably in recent years. The object of this study was to evaluate advances in operative therapy for esophageal cancer in Japan. Method We evaluated mortality, morbidity, and prognosis in 1000 consecutive patients who underwent esophagectomy for esophageal cancer at a single institution in Japan. The patients were divided into 3 groups according to the period when esophagectomy was performed: Group I (n = 197), 1964–1980; group II (n = 432), 1981–1993; and group III (n = 371), 1993–2006. Results The incidence of squamous cell carcinoma was 94%. The morbidity rates were 62%, 38%, and 33 %, in groups I, II, and III, respectively ( P < 0.01, groups I vs II and III), and the in-hospital mortality rates were 14.2%, 5.1%, and 2.4%, respectively ( P < 0.01, between each group). The 5-year overall survival rate was 30% (14%, 27%, and 46% in groups I, II, and III, respectively; P < 0.0001). Multivariate analysis revealed age, gender, depth of invasion, node metastasis, distant metastasis, curability, extent of lymphadenectomy, resectability, and the period when the operation was performed as independent prognostic factors. Conclusion Generally, esophagectomy has been performed safely without critical complications; however, the prognosis has improved remarkably with advances in surgical techniques and treatment modalities.</description><subject>Adenocarcinoma - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagectomy - adverse effects</subject><subject>Esophagectomy - statistics & numerical data</subject><subject>Esophagectomy - trends</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Humans</subject><subject>Japan</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Surgery</subject><subject>Survival Analysis</subject><subject>Tumors</subject><issn>0039-6060</issn><issn>1532-7361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kl2r1DAQhosonvXoH_BCcqN3rZMm6YeIsBz85IAXKngX5qTTNWu3rZl0Yf-9KbsoeOFNJiTP-054J1n2VEIhQVYv9wUvYVeUAHUhyyKVe9lGGlXmtark_WwDoNq8ggquskfMewBotWweZleyUbUGXW-y47Y74uiIhR8F8TT_wB3hINx6GMTagMJpvfyEM46vxHYUOOJwYs9i6oVMpsJNI5Nboj-SmDF6GiOLGAgjdQKjQMF-3A2UbDj6uER6nD3ocWB6cqnX2bd3b7_efMhvP7__eLO9zZ0BE_OuxMoBlBpJKkdkqG61oQboru8NUI8qLWR0o6WSrlKVgRbThrBtTF-q6-zF2XcO06-FONqDZ0fDgCNNC9satG6VhgSWZ9CFiTlQb-fgDxhOVoJd07Z7u4Zh17StLG0qSfTs4r7cHaj7K7nEm4DnFwDZ4dCHlKrnP1wJpal1YxL3-sxRyuLoKVh2KUVHnQ_kou0m__93vPlH7gY_-tTxJ52I99MS0sjYSstJYL-s_2L9FtCk6TXVd_UbcAWzbw</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Morita, Masaru, MD, PhD, FACS</creator><creator>Yoshida, Rintaro, MD</creator><creator>Ikeda, Keisuke, MD</creator><creator>Egashira, Akinori, MD, PhD</creator><creator>Oki, Eiji, MD PhD</creator><creator>Sadanaga, Noriaki, MD, PhD</creator><creator>Kakeji, Yoshihiro, MD, PhD, FACS</creator><creator>Yamanaka, Takeharu, PhD</creator><creator>Maehara, Yoshihiko, MD, PhD, FACS</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Advances in esophageal cancer surgery in Japan: An analysis of 1000 consecutive patients treated at a single institute</title><author>Morita, Masaru, MD, PhD, FACS ; Yoshida, Rintaro, MD ; Ikeda, Keisuke, MD ; Egashira, Akinori, MD, PhD ; Oki, Eiji, MD PhD ; Sadanaga, Noriaki, MD, PhD ; Kakeji, Yoshihiro, MD, PhD, FACS ; Yamanaka, Takeharu, PhD ; Maehara, Yoshihiko, MD, PhD, FACS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-d2a6c0024ae13cee5e7945e80ebff50efa30efe5484131c636509a1c6ea985f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adenocarcinoma - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagectomy - adverse effects</topic><topic>Esophagectomy - statistics & numerical data</topic><topic>Esophagectomy - trends</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Humans</topic><topic>Japan</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Surgery</topic><topic>Survival Analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morita, Masaru, MD, PhD, FACS</creatorcontrib><creatorcontrib>Yoshida, Rintaro, MD</creatorcontrib><creatorcontrib>Ikeda, Keisuke, MD</creatorcontrib><creatorcontrib>Egashira, Akinori, MD, PhD</creatorcontrib><creatorcontrib>Oki, Eiji, MD PhD</creatorcontrib><creatorcontrib>Sadanaga, Noriaki, MD, PhD</creatorcontrib><creatorcontrib>Kakeji, Yoshihiro, MD, PhD, FACS</creatorcontrib><creatorcontrib>Yamanaka, Takeharu, PhD</creatorcontrib><creatorcontrib>Maehara, Yoshihiko, MD, PhD, FACS</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morita, Masaru, MD, PhD, FACS</au><au>Yoshida, Rintaro, MD</au><au>Ikeda, Keisuke, MD</au><au>Egashira, Akinori, MD, PhD</au><au>Oki, Eiji, MD PhD</au><au>Sadanaga, Noriaki, MD, PhD</au><au>Kakeji, Yoshihiro, MD, PhD, FACS</au><au>Yamanaka, Takeharu, PhD</au><au>Maehara, Yoshihiko, MD, PhD, FACS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advances in esophageal cancer surgery in Japan: An analysis of 1000 consecutive patients treated at a single institute</atitle><jtitle>Surgery</jtitle><addtitle>Surgery</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>143</volume><issue>4</issue><spage>499</spage><epage>508</epage><pages>499-508</pages><issn>0039-6060</issn><eissn>1532-7361</eissn><coden>SURGAZ</coden><abstract>Background In Japan, most esophageal cancers are squamous cell carcinomas, and the results of esophagectomy have improved remarkably in recent years. The object of this study was to evaluate advances in operative therapy for esophageal cancer in Japan. Method We evaluated mortality, morbidity, and prognosis in 1000 consecutive patients who underwent esophagectomy for esophageal cancer at a single institution in Japan. The patients were divided into 3 groups according to the period when esophagectomy was performed: Group I (n = 197), 1964–1980; group II (n = 432), 1981–1993; and group III (n = 371), 1993–2006. Results The incidence of squamous cell carcinoma was 94%. The morbidity rates were 62%, 38%, and 33 %, in groups I, II, and III, respectively ( P < 0.01, groups I vs II and III), and the in-hospital mortality rates were 14.2%, 5.1%, and 2.4%, respectively ( P < 0.01, between each group). The 5-year overall survival rate was 30% (14%, 27%, and 46% in groups I, II, and III, respectively; P < 0.0001). Multivariate analysis revealed age, gender, depth of invasion, node metastasis, distant metastasis, curability, extent of lymphadenectomy, resectability, and the period when the operation was performed as independent prognostic factors. Conclusion Generally, esophagectomy has been performed safely without critical complications; however, the prognosis has improved remarkably with advances in surgical techniques and treatment modalities.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>18374047</pmid><doi>10.1016/j.surg.2007.12.007</doi><tpages>10</tpages></addata></record> |
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| subjects | Adenocarcinoma - surgery Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Squamous Cell - surgery Esophageal Neoplasms - surgery Esophagectomy - adverse effects Esophagectomy - statistics & numerical data Esophagectomy - trends Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen General aspects Humans Japan Male Medical sciences Middle Aged Prognosis Surgery Survival Analysis Tumors |
| title | Advances in esophageal cancer surgery in Japan: An analysis of 1000 consecutive patients treated at a single institute |
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