Synthesis and antimicrobial activity of symmetrical two-tailed dendritic tricarboxylato amphiphiles

Antimicrobial activity of the water-soluble, dendritic tricarboxylato amphiphiles varies by microorganism as whether one or two tails or hydrophobicity or length predicts inhibition of growth. Two series of water-soluble, symmetrical two-tailed homologous dendritic amphiphiles—R 2NCONHC((CH 2) 2COOH...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2007-06, Vol.15 (11), p.3842-3853
Hauptverfasser:	Sugandhi, Eko W., Falkinham, Joseph O., Gandour, Richard D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Antimicrobial activity Bacteria - drug effects Biological and medical sciences Candida albicans - drug effects Cryptococcus neoformans - drug effects Dendrimers - chemical synthesis Dendrimers - chemistry Dendrimers - pharmacology Dendritic amphiphiles Hydrophobic and Hydrophilic Interactions Hydrophobicity Medical sciences Pharmacology. Drug treatments Solubility Structure-Activity Relationship Structure–activity study Water - chemistry
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