Endoglin (CD105): A Marker of Tumor Vasculature and Potential Target for Therapy

Endoglin (CD105) is an accessory protein of the transforming growth factor-β receptor system expressed on vascular endothelial cells. Mutation of the endoglin gene is associated with hereditary hemorrhagic telangiectasias, or Osler-Weber-Rendu syndrome, and has been studied extensively in the contex...

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Veröffentlicht in:	Clinical cancer research 2008-04, Vol.14 (7), p.1931-1937
Hauptverfasser:	DALLAS, Nikolaos A, SAMUEL, Shaija, LING XIA, FAN FAN, GRAY, Michael J, LIM, Sherry J, ELLIS, Lee M
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animals Antigens, CD - physiology Antineoplastic agents Biological and medical sciences Biomarkers, Tumor - analysis cancer CD105 Endoglin Endothelial Cells - metabolism Humans Medical sciences Neoplasms - blood supply Neoplasms - metabolism Neovascularization, Pathologic - physiopathology Pharmacology. Drug treatments Receptors, Cell Surface - physiology Transforming Growth Factor beta - metabolism vasculature
Online-Zugang:	Volltext
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