A comparable, chemical and pharmacological analysis of the traditional Chinese medicinal herbs Oldenlandia diffusa and O. corymbosa and a new valuation of their biological potential
The herb of Oldenlandia diffusa (Willd.) Roxb. (Family Rubiaceae) is well-known in Chinese folk medicine for the treatment of hepatitis and malignant tumors of the liver, lung and stomach. However, another herb of O. corymbosa (L.) Lam is also used interchangeably in South China for treating the sam...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2008-04, Vol.15 (4), p.259-267 |
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| creator | Liang, Zhitao He, Mingfang Fong, Wangfun Jiang, Zhihong Zhao, Zhongzhen |
| description | The herb of
Oldenlandia diffusa (Willd.) Roxb. (Family Rubiaceae) is well-known in Chinese folk medicine for the treatment of hepatitis and malignant tumors of the liver, lung and stomach. However, another herb of
O. corymbosa (L.) Lam is also used interchangeably in South China for treating the same conditions. To compare the efficacy of the two herbs, the antiproliferative effect of their extracts and the antiangiogenic activity of their main constituents were appraised. The Sulforhodamine B (SRB) assay in human hepatoma HepG2 cells and human colon carcinoma CaCo2 cells and the zebrafish angiogenic model were used for this purpose. The results showed almost no antiproliferative effect of the methanol extracts from
O. diffusa and
O. corymbosa, while the chloroform extracts exhibited slightly antiproliferative effects. The main components had almost no effect on zebrafish angiogenic vessel formation at the concentrations tested. The results suggest that the mechanism of antitumor activity of
O. diffusa may not be attributed to the antiproliferative and antiangiogenic effects. |
| doi_str_mv | 10.1016/j.phymed.2008.01.003 |
| format | Article |
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Oldenlandia diffusa (Willd.) Roxb. (Family Rubiaceae) is well-known in Chinese folk medicine for the treatment of hepatitis and malignant tumors of the liver, lung and stomach. However, another herb of
O. corymbosa (L.) Lam is also used interchangeably in South China for treating the same conditions. To compare the efficacy of the two herbs, the antiproliferative effect of their extracts and the antiangiogenic activity of their main constituents were appraised. The Sulforhodamine B (SRB) assay in human hepatoma HepG2 cells and human colon carcinoma CaCo2 cells and the zebrafish angiogenic model were used for this purpose. The results showed almost no antiproliferative effect of the methanol extracts from
O. diffusa and
O. corymbosa, while the chloroform extracts exhibited slightly antiproliferative effects. The main components had almost no effect on zebrafish angiogenic vessel formation at the concentrations tested. The results suggest that the mechanism of antitumor activity of
O. diffusa may not be attributed to the antiproliferative and antiangiogenic effects.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2008.01.003</identifier><identifier>PMID: 18339527</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Adenocarcinoma - drug therapy ; Angiogenesis Inhibitors - isolation & purification ; Animals ; Antiproliferative ; Antitumor ; Caco-2 Cells ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Chromatography, High Pressure Liquid ; Colonic Neoplasms - drug therapy ; Control ; Glucosides - isolation & purification ; Health aspects ; High-performance liquid chromatography (HPLC) ; Humans ; Iridoids - isolation & purification ; Liquid chromatography ; Medicinal plants ; Oldenlandia - chemistry ; Oldenlandia corymbosa ; Oldenlandia diffusa ; Oleanolic Acid - isolation & purification ; Phytotherapy ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Pyrans - isolation & purification ; Tumors ; Zebrafish</subject><ispartof>Phytomedicine (Stuttgart), 2008-04, Vol.15 (4), p.259-267</ispartof><rights>2008 Elsevier GmbH</rights><rights>COPYRIGHT 2008 Urban & Fischer Verlag</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-19b1cdf77c1ecc1f6f10e5ec5ac7b012738fa2c11b184dec9fa7d55c588c344e3</citedby><cites>FETCH-LOGICAL-c465t-19b1cdf77c1ecc1f6f10e5ec5ac7b012738fa2c11b184dec9fa7d55c588c344e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.phymed.2008.01.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18339527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Zhitao</creatorcontrib><creatorcontrib>He, Mingfang</creatorcontrib><creatorcontrib>Fong, Wangfun</creatorcontrib><creatorcontrib>Jiang, Zhihong</creatorcontrib><creatorcontrib>Zhao, Zhongzhen</creatorcontrib><title>A comparable, chemical and pharmacological analysis of the traditional Chinese medicinal herbs Oldenlandia diffusa and O. corymbosa and a new valuation of their biological potential</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>The herb of
Oldenlandia diffusa (Willd.) Roxb. (Family Rubiaceae) is well-known in Chinese folk medicine for the treatment of hepatitis and malignant tumors of the liver, lung and stomach. However, another herb of
O. corymbosa (L.) Lam is also used interchangeably in South China for treating the same conditions. To compare the efficacy of the two herbs, the antiproliferative effect of their extracts and the antiangiogenic activity of their main constituents were appraised. The Sulforhodamine B (SRB) assay in human hepatoma HepG2 cells and human colon carcinoma CaCo2 cells and the zebrafish angiogenic model were used for this purpose. The results showed almost no antiproliferative effect of the methanol extracts from
O. diffusa and
O. corymbosa, while the chloroform extracts exhibited slightly antiproliferative effects. The main components had almost no effect on zebrafish angiogenic vessel formation at the concentrations tested. The results suggest that the mechanism of antitumor activity of
O. diffusa may not be attributed to the antiproliferative and antiangiogenic effects.</description><subject>Adenocarcinoma - drug therapy</subject><subject>Angiogenesis Inhibitors - isolation & purification</subject><subject>Animals</subject><subject>Antiproliferative</subject><subject>Antitumor</subject><subject>Caco-2 Cells</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Control</subject><subject>Glucosides - isolation & purification</subject><subject>Health aspects</subject><subject>High-performance liquid chromatography (HPLC)</subject><subject>Humans</subject><subject>Iridoids - isolation & purification</subject><subject>Liquid chromatography</subject><subject>Medicinal plants</subject><subject>Oldenlandia - chemistry</subject><subject>Oldenlandia corymbosa</subject><subject>Oldenlandia diffusa</subject><subject>Oleanolic Acid - isolation & purification</subject><subject>Phytotherapy</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Pyrans - isolation & purification</subject><subject>Tumors</subject><subject>Zebrafish</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kl2L1DAUhoso7rj6D0QCgle25kzbSXsjDINfsDA3Ct6F9PRkmiFtatLZZX6Y_8_UKQvCILkIvHnOZ94keQ08Aw6bD8ds7M49tdma8yrjkHGeP0lWsIEq5XX582my4nVRpAIgv0lehHDkHIpa8OfJDVR5XpdrsUp-bxm6flReNZbeM-yoN6gsU0PLxk75XqGz7rBoyp6DCcxpNnXEJq9aMxkXZbbrzECBWGzIoJmVjnwT2N62NNiYzSjWGq1PQf3Nvc9iXX_uG7cIig30wO6VPak55VLDeNaYxwZGN9EwGWVfJs-0soFeLfdt8uPzp--7r-nd_su33fYuxWJTTinUDWCrhUAgRNAbDZxKwlKhaDisRV5ptUaABqqiJay1Em1ZYllVmBcF5bfJu0ve0btfJwqT7E1AsnEgcqcgBS-KasNFBN9ewIOyJM2gXVwOzrDcgqhLXnJeRyq9Qh1oIK-sG0ibKP_DZ1f4eNr5l64GFJcA9C4ET1qO3vTKnyVwObtGHuXFNXJ2jeQgo2ti2JtlzFMzvz0GLTaJwMcLQHHZ94a8DGhowPjZnnCSrTP_r_AH8xXX8Q</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Liang, Zhitao</creator><creator>He, Mingfang</creator><creator>Fong, Wangfun</creator><creator>Jiang, Zhihong</creator><creator>Zhao, Zhongzhen</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>A comparable, chemical and pharmacological analysis of the traditional Chinese medicinal herbs Oldenlandia diffusa and O. corymbosa and a new valuation of their biological potential</title><author>Liang, Zhitao ; He, Mingfang ; Fong, Wangfun ; Jiang, Zhihong ; Zhao, Zhongzhen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-19b1cdf77c1ecc1f6f10e5ec5ac7b012738fa2c11b184dec9fa7d55c588c344e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adenocarcinoma - drug therapy</topic><topic>Angiogenesis Inhibitors - isolation & purification</topic><topic>Animals</topic><topic>Antiproliferative</topic><topic>Antitumor</topic><topic>Caco-2 Cells</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Colonic Neoplasms - drug therapy</topic><topic>Control</topic><topic>Glucosides - isolation & purification</topic><topic>Health aspects</topic><topic>High-performance liquid chromatography (HPLC)</topic><topic>Humans</topic><topic>Iridoids - isolation & purification</topic><topic>Liquid chromatography</topic><topic>Medicinal plants</topic><topic>Oldenlandia - chemistry</topic><topic>Oldenlandia corymbosa</topic><topic>Oldenlandia diffusa</topic><topic>Oleanolic Acid - isolation & purification</topic><topic>Phytotherapy</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Pyrans - isolation & purification</topic><topic>Tumors</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Zhitao</creatorcontrib><creatorcontrib>He, Mingfang</creatorcontrib><creatorcontrib>Fong, Wangfun</creatorcontrib><creatorcontrib>Jiang, Zhihong</creatorcontrib><creatorcontrib>Zhao, Zhongzhen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Zhitao</au><au>He, Mingfang</au><au>Fong, Wangfun</au><au>Jiang, Zhihong</au><au>Zhao, Zhongzhen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparable, chemical and pharmacological analysis of the traditional Chinese medicinal herbs Oldenlandia diffusa and O. corymbosa and a new valuation of their biological potential</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>15</volume><issue>4</issue><spage>259</spage><epage>267</epage><pages>259-267</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>The herb of
Oldenlandia diffusa (Willd.) Roxb. (Family Rubiaceae) is well-known in Chinese folk medicine for the treatment of hepatitis and malignant tumors of the liver, lung and stomach. However, another herb of
O. corymbosa (L.) Lam is also used interchangeably in South China for treating the same conditions. To compare the efficacy of the two herbs, the antiproliferative effect of their extracts and the antiangiogenic activity of their main constituents were appraised. The Sulforhodamine B (SRB) assay in human hepatoma HepG2 cells and human colon carcinoma CaCo2 cells and the zebrafish angiogenic model were used for this purpose. The results showed almost no antiproliferative effect of the methanol extracts from
O. diffusa and
O. corymbosa, while the chloroform extracts exhibited slightly antiproliferative effects. The main components had almost no effect on zebrafish angiogenic vessel formation at the concentrations tested. The results suggest that the mechanism of antitumor activity of
O. diffusa may not be attributed to the antiproliferative and antiangiogenic effects.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>18339527</pmid><doi>10.1016/j.phymed.2008.01.003</doi><tpages>9</tpages></addata></record> |
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| subjects | Adenocarcinoma - drug therapy Angiogenesis Inhibitors - isolation & purification Animals Antiproliferative Antitumor Caco-2 Cells Cell Line, Tumor Cell Proliferation - drug effects Chromatography, High Pressure Liquid Colonic Neoplasms - drug therapy Control Glucosides - isolation & purification Health aspects High-performance liquid chromatography (HPLC) Humans Iridoids - isolation & purification Liquid chromatography Medicinal plants Oldenlandia - chemistry Oldenlandia corymbosa Oldenlandia diffusa Oleanolic Acid - isolation & purification Phytotherapy Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Pyrans - isolation & purification Tumors Zebrafish |
| title | A comparable, chemical and pharmacological analysis of the traditional Chinese medicinal herbs Oldenlandia diffusa and O. corymbosa and a new valuation of their biological potential |
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