Regulation and biological activities of the autotaxin–LPA axis
Autotaxin (ATX), or nucleotide pyrophosphatase/phosphodiesterase 2 (NPP2), is an exo-enzyme originally identified as a tumor cell autocrine motility factor. ATX is unique among the NPPs in that it primarily functions as a lysophospholipase D, converting lysophosphatidylcholine into the lipid mediato...
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| Veröffentlicht in: | Progress in lipid research 2007-03, Vol.46 (2), p.145-160 |
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| creator | van Meeteren, Laurens A. Moolenaar, Wouter H. |
| description | Autotaxin (ATX), or nucleotide pyrophosphatase/phosphodiesterase 2 (NPP2), is an exo-enzyme originally identified as a tumor cell autocrine motility factor. ATX is unique among the NPPs in that it primarily functions as a lysophospholipase D, converting lysophosphatidylcholine into the lipid mediator lysophosphatidic acid (LPA). LPA acts on specific G protein-coupled receptors to elicit a wide range of cellular responses, ranging from cell proliferation and migration to neurite remodeling and cytokine production. While LPA signaling has been studied extensively over the last decade, we are only now beginning to explore the properties and biological importance of ATX as the major LPA-producing phospholipase. In this review, we highlight recent advances in our understanding of the ATX–LPA axis, giving first an update on LPA action and then focusing on ATX, in particular its regulation, its link to cancer and its vital role in vascular development. |
| doi_str_mv | 10.1016/j.plipres.2007.02.001 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0163-7827 |
| ispartof | Progress in lipid research, 2007-03, Vol.46 (2), p.145-160 |
| issn | 0163-7827 1873-2194 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Autotaxin G Protein-coupled receptor Humans Lysophosphatidic acid Lysophospholipids - metabolism Multienzyme Complexes - metabolism Nucleotide pyrophosphatase/phosphodiesterase Phosphodiesterase I - metabolism Phospholipase D Pyrophosphatases - metabolism Receptors, Lysophosphatidic Acid - metabolism Substrate Specificity |
| title | Regulation and biological activities of the autotaxin–LPA axis |
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