Acute β-blockade prevents myocardial β-adrenergic receptor desensitization and preserves early ventricular function after brain death

Objective β-Adrenergic receptor desensitization through activation of the G protein–coupled receptor kinase 2 is an important mechanism of early cardiac dysfunction after brain death. We hypothesized that acute β-blockade can prevent myocardial β-adrenergic receptor desensitization after brain death...

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Veröffentlicht in:	The Journal of thoracic and cardiovascular surgery 2008-04, Vol.135 (4), p.792-798
Hauptverfasser:	Pandalai, Prakash K., MD, McLean, Kelly M., MD, Bulcao, Christian F., MD, MBA, Duffy, Jodie Y., PhD, D'Souza, Karen M., PhD, Merrill, Walter H., MD, Pearl, Jeffrey M., MD, Akhter, Shahab A., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Animals Brain Death Cardiothoracic Surgery Disease Models, Animal Heart - drug effects Heart - physiopathology Myocardium - metabolism Propanolamines - pharmacology Receptors, Adrenergic, beta - drug effects Swine Ventricular Function - drug effects
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