Impaired Fas-induced apoptosis of T lymphocytes in patients with abdominal aortic aneurysms

Objective Homeostasis of the immune system is maintained by apoptotic elimination of potentially pathogenic autoreactive lymphocytes. Emerging evidence shows that Fas-mediated apoptosis is impaired in activated lymphocytes from patients with autoimmune disease. The aim of this work was to assess apo...

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Veröffentlicht in:	Journal of vascular surgery 2007-05, Vol.45 (5), p.1039-1046
Hauptverfasser:	Zhang, Jian, MD, PhD, Böckler, Dittmar, MD, PhD, Ryschich, Eduard, MD, Klemm, Klaus, MD, Schumacher, Hardy, MD, PhD, Schmidt, Jan, MD, PhD, Allenberg, Jens R., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antibodies, Monoclonal Aortic Aneurysm, Abdominal - immunology Apoptosis - immunology Atherosclerosis - immunology Autoimmunity - physiology Down-Regulation - immunology fas Receptor - immunology fas Receptor - physiology Female Glucocorticoids - pharmacology Humans Male Methylprednisolone - pharmacology Middle Aged Sphingosine - analogs & derivatives Sphingosine - pharmacology Surgery T-Lymphocytes - immunology
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