Interleukin-21: basic biology and implications for cancer and autoimmunity

Interleukin-21 (IL-21), a potent immunomodulatory four-alpha-helical-bundle type I cytokine, is produced by NKT and CD4(+) T cells and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhanced proliferation of lymphoid cells, increa...

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Veröffentlicht in:	Annual review of immunology 2008-01, Vol.26 (1), p.57-79
Hauptverfasser:	Spolski, Rosanne, Leonard, Warren J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune Diseases - drug therapy Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Autoimmunity - physiology Dendritic Cells - physiology Humans Interleukins - antagonists & inhibitors Interleukins - physiology Interleukins - therapeutic use Lymphocytes - physiology Neoplasms - drug therapy Neoplasms - immunology
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