Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation
Twelve compounds isolated from Alpinia mutica Roxb., Kaempferia rotunda Linn., Curcuma xanthorhiza Roxb., Curcuma aromatica Valeton and Zingiber zerumbet Smith (Family: Zingiberaceae) and three synthesized derivatives of xanthorrhizol were evaluated for their ability to inhibit arachidonic acid- (AA...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2008-04, Vol.15 (4), p.306-309 |
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| creator | Jantan, I. Raweh, S.M. Sirat, H.M. Jamil, S. Mohd Yasin, Y.H. Jalil, J. Jamal, J.A. |
| description | Twelve compounds isolated from
Alpinia mutica Roxb.,
Kaempferia rotunda Linn.,
Curcuma xanthorhiza Roxb.,
Curcuma aromatica Valeton and
Zingiber zerumbet Smith (Family: Zingiberaceae) and three synthesized derivatives of xanthorrhizol were evaluated for their ability to inhibit arachidonic acid- (AA), collagen- and ADP-induced platelet aggregation in human whole blood. Antiplatelet activity of the compounds was measured
in vitro by the Chrono Log whole blood aggregometer using an electrical impedance method. Among the compounds tested, curcumin from
C. aromatica, cardamonin, pinocembrine and 5,6-dehydrokawain from
A. mutica and 3-deacetylcrotepoxide from
K. rotunda showed strong inhibition on platelet aggregation induced by AA with IC
50 values of less than 84
μM. Curcumin was the most effective antiplatelet compound as it inhibited AA-, collagen- and ADP-induced platelet aggregation with IC
50 values of 37.5, 60.9 and 45.7
μM, respectively. |
| doi_str_mv | 10.1016/j.phymed.2007.08.002 |
| format | Article |
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Alpinia mutica Roxb.,
Kaempferia rotunda Linn.,
Curcuma xanthorhiza Roxb.,
Curcuma aromatica Valeton and
Zingiber zerumbet Smith (Family: Zingiberaceae) and three synthesized derivatives of xanthorrhizol were evaluated for their ability to inhibit arachidonic acid- (AA), collagen- and ADP-induced platelet aggregation in human whole blood. Antiplatelet activity of the compounds was measured
in vitro by the Chrono Log whole blood aggregometer using an electrical impedance method. Among the compounds tested, curcumin from
C. aromatica, cardamonin, pinocembrine and 5,6-dehydrokawain from
A. mutica and 3-deacetylcrotepoxide from
K. rotunda showed strong inhibition on platelet aggregation induced by AA with IC
50 values of less than 84
μM. Curcumin was the most effective antiplatelet compound as it inhibited AA-, collagen- and ADP-induced platelet aggregation with IC
50 values of 37.5, 60.9 and 45.7
μM, respectively.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2007.08.002</identifier><identifier>PMID: 17913483</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Antiplatelet aggregation ; Arachidonic acid ; Blood platelet disorders ; Care and treatment ; Chalcones - isolation & purification ; Chalcones - pharmacology ; Control ; Curcumin ; Curcumin - isolation & purification ; Curcumin - pharmacology ; Flavanones - isolation & purification ; Flavanones - pharmacology ; Fruit - chemistry ; Health aspects ; Human whole blood ; Humans ; Materia medica, Vegetable ; Plant extracts ; Plant Extracts - pharmacology ; Platelet Aggregation - drug effects ; Pyrones - isolation & purification ; Pyrones - pharmacology ; Rhizome - chemistry ; Structure-Activity Relationship ; Xanthorrhizol ; Zingiberaceae ; Zingiberaceae - chemistry</subject><ispartof>Phytomedicine (Stuttgart), 2008-04, Vol.15 (4), p.306-309</ispartof><rights>2007 Elsevier GmbH</rights><rights>COPYRIGHT 2008 Urban & Fischer Verlag</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c531t-e8bac810fbbd4d83ea95c6348b1ff6252ad7548a463533de6beba1ab172dc4e23</citedby><cites>FETCH-LOGICAL-c531t-e8bac810fbbd4d83ea95c6348b1ff6252ad7548a463533de6beba1ab172dc4e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.phymed.2007.08.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17913483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jantan, I.</creatorcontrib><creatorcontrib>Raweh, S.M.</creatorcontrib><creatorcontrib>Sirat, H.M.</creatorcontrib><creatorcontrib>Jamil, S.</creatorcontrib><creatorcontrib>Mohd Yasin, Y.H.</creatorcontrib><creatorcontrib>Jalil, J.</creatorcontrib><creatorcontrib>Jamal, J.A.</creatorcontrib><title>Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>Twelve compounds isolated from
Alpinia mutica Roxb.,
Kaempferia rotunda Linn.,
Curcuma xanthorhiza Roxb.,
Curcuma aromatica Valeton and
Zingiber zerumbet Smith (Family: Zingiberaceae) and three synthesized derivatives of xanthorrhizol were evaluated for their ability to inhibit arachidonic acid- (AA), collagen- and ADP-induced platelet aggregation in human whole blood. Antiplatelet activity of the compounds was measured
in vitro by the Chrono Log whole blood aggregometer using an electrical impedance method. Among the compounds tested, curcumin from
C. aromatica, cardamonin, pinocembrine and 5,6-dehydrokawain from
A. mutica and 3-deacetylcrotepoxide from
K. rotunda showed strong inhibition on platelet aggregation induced by AA with IC
50 values of less than 84
μM. Curcumin was the most effective antiplatelet compound as it inhibited AA-, collagen- and ADP-induced platelet aggregation with IC
50 values of 37.5, 60.9 and 45.7
μM, respectively.</description><subject>Antiplatelet aggregation</subject><subject>Arachidonic acid</subject><subject>Blood platelet disorders</subject><subject>Care and treatment</subject><subject>Chalcones - isolation & purification</subject><subject>Chalcones - pharmacology</subject><subject>Control</subject><subject>Curcumin</subject><subject>Curcumin - isolation & purification</subject><subject>Curcumin - pharmacology</subject><subject>Flavanones - isolation & purification</subject><subject>Flavanones - pharmacology</subject><subject>Fruit - chemistry</subject><subject>Health aspects</subject><subject>Human whole blood</subject><subject>Humans</subject><subject>Materia medica, Vegetable</subject><subject>Plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Platelet Aggregation - drug effects</subject><subject>Pyrones - isolation & purification</subject><subject>Pyrones - pharmacology</subject><subject>Rhizome - chemistry</subject><subject>Structure-Activity Relationship</subject><subject>Xanthorrhizol</subject><subject>Zingiberaceae</subject><subject>Zingiberaceae - chemistry</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV2L1DAUhoMo7rj6D0QCgnetSZv040ZYltVdWPBGUbwJ-TjpZGiTmrTC_HszdBAWBslFIHnenJzzIPSWkpIS2nw8lPP-OIEpK0LaknQlIdUztKMN7QrS85_P0Y70jBUtpfUVepXSgRDK-pa8RFe07WnNunqHfjz4vVNuCfGIwVrQCw4W6zDNYfUmYRvDhH85PzgFUWqQgNMM2kHCweP9OkmP51EuMMKC5TBEGOTign-NXlg5Jnhz3q_R9893327vi8evXx5ubx4LzWu6FNApqTtKrFKGma4G2XPd5K8pam1T8UqalrNOsqbmdW2gUaAklYq2ldEMqvoafdjenWP4vUJaxOSShnGUHsKaREsY46SjGXy_gYMcQThvw5L7OcHiJo-DE04oz1RxgRrA5-bH4MG6fPyELy_weRmYnL4YYFtAx5BSBCvm6CYZj4IScfIqDmLzKk5eBelE9ppj785trup09y90FpmBTxsAedh_HESRsiSvwbiYpQoT3P8r_AUI57W7</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Jantan, I.</creator><creator>Raweh, S.M.</creator><creator>Sirat, H.M.</creator><creator>Jamil, S.</creator><creator>Mohd Yasin, Y.H.</creator><creator>Jalil, J.</creator><creator>Jamal, J.A.</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation</title><author>Jantan, I. ; Raweh, S.M. ; Sirat, H.M. ; Jamil, S. ; Mohd Yasin, Y.H. ; Jalil, J. ; Jamal, J.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c531t-e8bac810fbbd4d83ea95c6348b1ff6252ad7548a463533de6beba1ab172dc4e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Antiplatelet aggregation</topic><topic>Arachidonic acid</topic><topic>Blood platelet disorders</topic><topic>Care and treatment</topic><topic>Chalcones - isolation & purification</topic><topic>Chalcones - pharmacology</topic><topic>Control</topic><topic>Curcumin</topic><topic>Curcumin - isolation & purification</topic><topic>Curcumin - pharmacology</topic><topic>Flavanones - isolation & purification</topic><topic>Flavanones - pharmacology</topic><topic>Fruit - chemistry</topic><topic>Health aspects</topic><topic>Human whole blood</topic><topic>Humans</topic><topic>Materia medica, Vegetable</topic><topic>Plant extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>Platelet Aggregation - drug effects</topic><topic>Pyrones - isolation & purification</topic><topic>Pyrones - pharmacology</topic><topic>Rhizome - chemistry</topic><topic>Structure-Activity Relationship</topic><topic>Xanthorrhizol</topic><topic>Zingiberaceae</topic><topic>Zingiberaceae - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jantan, I.</creatorcontrib><creatorcontrib>Raweh, S.M.</creatorcontrib><creatorcontrib>Sirat, H.M.</creatorcontrib><creatorcontrib>Jamil, S.</creatorcontrib><creatorcontrib>Mohd Yasin, Y.H.</creatorcontrib><creatorcontrib>Jalil, J.</creatorcontrib><creatorcontrib>Jamal, J.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jantan, I.</au><au>Raweh, S.M.</au><au>Sirat, H.M.</au><au>Jamil, S.</au><au>Mohd Yasin, Y.H.</au><au>Jalil, J.</au><au>Jamal, J.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>15</volume><issue>4</issue><spage>306</spage><epage>309</epage><pages>306-309</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>Twelve compounds isolated from
Alpinia mutica Roxb.,
Kaempferia rotunda Linn.,
Curcuma xanthorhiza Roxb.,
Curcuma aromatica Valeton and
Zingiber zerumbet Smith (Family: Zingiberaceae) and three synthesized derivatives of xanthorrhizol were evaluated for their ability to inhibit arachidonic acid- (AA), collagen- and ADP-induced platelet aggregation in human whole blood. Antiplatelet activity of the compounds was measured
in vitro by the Chrono Log whole blood aggregometer using an electrical impedance method. Among the compounds tested, curcumin from
C. aromatica, cardamonin, pinocembrine and 5,6-dehydrokawain from
A. mutica and 3-deacetylcrotepoxide from
K. rotunda showed strong inhibition on platelet aggregation induced by AA with IC
50 values of less than 84
μM. Curcumin was the most effective antiplatelet compound as it inhibited AA-, collagen- and ADP-induced platelet aggregation with IC
50 values of 37.5, 60.9 and 45.7
μM, respectively.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>17913483</pmid><doi>10.1016/j.phymed.2007.08.002</doi><tpages>4</tpages></addata></record> |
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| ispartof | Phytomedicine (Stuttgart), 2008-04, Vol.15 (4), p.306-309 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Antiplatelet aggregation Arachidonic acid Blood platelet disorders Care and treatment Chalcones - isolation & purification Chalcones - pharmacology Control Curcumin Curcumin - isolation & purification Curcumin - pharmacology Flavanones - isolation & purification Flavanones - pharmacology Fruit - chemistry Health aspects Human whole blood Humans Materia medica, Vegetable Plant extracts Plant Extracts - pharmacology Platelet Aggregation - drug effects Pyrones - isolation & purification Pyrones - pharmacology Rhizome - chemistry Structure-Activity Relationship Xanthorrhizol Zingiberaceae Zingiberaceae - chemistry |
| title | Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation |
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