Simultaneous measurement of intracellular triphosphate metabolites of zidovudine, lamivudine and abacavir (carbovir) in human peripheral blood mononuclear cells by combined anion exchange solid phase extraction and LC–MS/MS

All nucleoside reverse transcriptase inhibitors (NRTI) must first be metabolized to their triphosphate forms in order to be active against HIV. Zidovudine (ZDV), abacavir (ABC) and lamivudine (3TC) have proven to be an efficacious combination. In order simultaneously to measure intracellular levels...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2007-05, Vol.850 (1), p.310-317
Hauptverfasser:	Robbins, Brian L., Poston, Philip A., Neal, Erin F., Slaughter, Clive, Rodman, John H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Antiviral drug metabolism Biological and medical sciences Carbovir triphosphate Chromatography, High Pressure Liquid - methods Dideoxynucleosides - blood Fundamental and applied biological sciences. Psychology General pharmacology HIV Infections - blood Human immunodeficiency virus Humans Lamivudine - blood Lamivudine triphosphate Medical sciences Pharmacology. Drug treatments Phosphates - blood Reference Standards Reverse Transcriptase Inhibitors - blood Tandem Mass Spectrometry - methods Zidovudine - blood Zidovudine triphosphate
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