Laser microdissection and microarray analysis of the hippocampus of Ras-GRF1 knockout mice reveals gene expression changes affecting signal transduction pathways related to memory and learning

Abstract We used manual macrodissection or laser capture microdissection (LCM) to isolate tissue sections of the hippocampus area of Ras-GRF1 wild type and knockout mice brains, and analyzed their transcriptional patterns using commercial oligonucleotide microarrays. Comparison between the transcrip...

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Veröffentlicht in:	Neuroscience 2007-04, Vol.146 (1), p.272-285
Hauptverfasser:	Fernández-Medarde, A, Porteros, A, de las Rivas, J, Núñez, A, Fuster, J.J, Santos, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cluster Analysis Fundamental and applied biological sciences. Psychology Gene Expression - genetics Gene Expression Profiling - methods Gene Expression Regulation - genetics hippocampus Hippocampus - metabolism In Situ Hybridization - methods In Vitro Techniques laser capture microdissection Lasers Mice Mice, Knockout microarray Microdissection - methods Neurology Oligonucleotide Array Sequence Analysis - methods Ras nucleotide exchange Ras-GRF1 ras-GRF1 - deficiency Signal Transduction - genetics transcriptome Vertebrates: nervous system and sense organs
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