In vivo quantification of response to treatment in patients with multiple myeloma by 1H magnetic resonance spectroscopy of bone marrow

Magnetic resonance imaging (MRI) is the gold standard non-invasive technique to detect malignant disease in the bone marrow. Proton magnetic resonance spectroscopy (MRS) can be performed as a quick adjunct to routine spinal MRI. We performed proton MRS to patients with multiple myeloma (MM) at diagn...

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Veröffentlicht in:Magma (New York, N.Y.) N.Y.), 2007-04, Vol.20 (2), p.93-101
Hauptverfasser: Oriol, Albert, Valverde, Daniel, Capellades, Jaume, Cabañas, Miquel E, Ribera, Josep-Maria, Arús, Carles
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container_title Magma (New York, N.Y.)
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creator Oriol, Albert
Valverde, Daniel
Capellades, Jaume
Cabañas, Miquel E
Ribera, Josep-Maria
Arús, Carles
description Magnetic resonance imaging (MRI) is the gold standard non-invasive technique to detect malignant disease in the bone marrow. Proton magnetic resonance spectroscopy (MRS) can be performed as a quick adjunct to routine spinal MRI. We performed proton MRS to patients with multiple myeloma (MM) at diagnosis and after treatment to investigate the possible correlation of MRS data with response to therapy. Twenty-one patients with newly diagnosed MM underwent combined MRI/MRS explorations of a transverse center section in the fifth lumbar vertebral body. MRS was acquired with STEAM and 40 ms TE. Areas of unsuppressed water and lipid resonances were used to calculate the lipid-to-water ratio (LWR). No association was detected between initial LWRs and the clinical characteristics of patients. Post treatment MRS was available in 16 patients of whom 11 (69%) presented an LWR increase, this included all complete responders (8/8, 100%, P = 0.012). A post-treatment LWR value equal to or larger than one is proposed as a non-invasive marker of complete response to treatment. Only patients responding to treatment presented a significant increase in bone marrow LWR after therapy. MRS may provide an adequate quantification of response to chemotherapy in patients with MM.
doi_str_mv 10.1007/s10334-007-0072-4
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Proton magnetic resonance spectroscopy (MRS) can be performed as a quick adjunct to routine spinal MRI. We performed proton MRS to patients with multiple myeloma (MM) at diagnosis and after treatment to investigate the possible correlation of MRS data with response to therapy. Twenty-one patients with newly diagnosed MM underwent combined MRI/MRS explorations of a transverse center section in the fifth lumbar vertebral body. MRS was acquired with STEAM and 40 ms TE. Areas of unsuppressed water and lipid resonances were used to calculate the lipid-to-water ratio (LWR). No association was detected between initial LWRs and the clinical characteristics of patients. Post treatment MRS was available in 16 patients of whom 11 (69%) presented an LWR increase, this included all complete responders (8/8, 100%, P = 0.012). A post-treatment LWR value equal to or larger than one is proposed as a non-invasive marker of complete response to treatment. 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subjects Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Biomarkers, Tumor - analysis
Bone marrow
Bone Marrow - metabolism
Cancer
Female
Humans
Lipids - analysis
Lumbar Vertebrae - metabolism
Magnetic Resonance Spectroscopy - methods
Male
Medical imaging
Middle Aged
Multiple myeloma
Multiple Myeloma - diagnosis
Multiple Myeloma - drug therapy
Multiple Myeloma - metabolism
NMR
Nuclear magnetic resonance
Prognosis
Protons
Spectroscopy
Spectrum analysis
Spine
Treatment Outcome
title In vivo quantification of response to treatment in patients with multiple myeloma by 1H magnetic resonance spectroscopy of bone marrow
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