In vivo quantification of response to treatment in patients with multiple myeloma by 1H magnetic resonance spectroscopy of bone marrow
Magnetic resonance imaging (MRI) is the gold standard non-invasive technique to detect malignant disease in the bone marrow. Proton magnetic resonance spectroscopy (MRS) can be performed as a quick adjunct to routine spinal MRI. We performed proton MRS to patients with multiple myeloma (MM) at diagn...
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Veröffentlicht in: | Magma (New York, N.Y.) N.Y.), 2007-04, Vol.20 (2), p.93-101 |
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creator | Oriol, Albert Valverde, Daniel Capellades, Jaume Cabañas, Miquel E Ribera, Josep-Maria Arús, Carles |
description | Magnetic resonance imaging (MRI) is the gold standard non-invasive technique to detect malignant disease in the bone marrow. Proton magnetic resonance spectroscopy (MRS) can be performed as a quick adjunct to routine spinal MRI. We performed proton MRS to patients with multiple myeloma (MM) at diagnosis and after treatment to investigate the possible correlation of MRS data with response to therapy.
Twenty-one patients with newly diagnosed MM underwent combined MRI/MRS explorations of a transverse center section in the fifth lumbar vertebral body. MRS was acquired with STEAM and 40 ms TE. Areas of unsuppressed water and lipid resonances were used to calculate the lipid-to-water ratio (LWR).
No association was detected between initial LWRs and the clinical characteristics of patients. Post treatment MRS was available in 16 patients of whom 11 (69%) presented an LWR increase, this included all complete responders (8/8, 100%, P = 0.012). A post-treatment LWR value equal to or larger than one is proposed as a non-invasive marker of complete response to treatment.
Only patients responding to treatment presented a significant increase in bone marrow LWR after therapy. MRS may provide an adequate quantification of response to chemotherapy in patients with MM. |
doi_str_mv | 10.1007/s10334-007-0072-4 |
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Twenty-one patients with newly diagnosed MM underwent combined MRI/MRS explorations of a transverse center section in the fifth lumbar vertebral body. MRS was acquired with STEAM and 40 ms TE. Areas of unsuppressed water and lipid resonances were used to calculate the lipid-to-water ratio (LWR).
No association was detected between initial LWRs and the clinical characteristics of patients. Post treatment MRS was available in 16 patients of whom 11 (69%) presented an LWR increase, this included all complete responders (8/8, 100%, P = 0.012). A post-treatment LWR value equal to or larger than one is proposed as a non-invasive marker of complete response to treatment.
Only patients responding to treatment presented a significant increase in bone marrow LWR after therapy. MRS may provide an adequate quantification of response to chemotherapy in patients with MM.</description><identifier>ISSN: 0968-5243</identifier><identifier>EISSN: 1352-8661</identifier><identifier>DOI: 10.1007/s10334-007-0072-4</identifier><identifier>PMID: 17410391</identifier><identifier>CODEN: MAGMEY</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Biomarkers, Tumor - analysis ; Bone marrow ; Bone Marrow - metabolism ; Cancer ; Female ; Humans ; Lipids - analysis ; Lumbar Vertebrae - metabolism ; Magnetic Resonance Spectroscopy - methods ; Male ; Medical imaging ; Middle Aged ; Multiple myeloma ; Multiple Myeloma - diagnosis ; Multiple Myeloma - drug therapy ; Multiple Myeloma - metabolism ; NMR ; Nuclear magnetic resonance ; Prognosis ; Protons ; Spectroscopy ; Spectrum analysis ; Spine ; Treatment Outcome</subject><ispartof>Magma (New York, N.Y.), 2007-04, Vol.20 (2), p.93-101</ispartof><rights>ESMRMB 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1711-2b01ac67eb819b0bceed9a700df7398800c63f060729892836f6defc8c64d8703</citedby><cites>FETCH-LOGICAL-c1711-2b01ac67eb819b0bceed9a700df7398800c63f060729892836f6defc8c64d8703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17410391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oriol, Albert</creatorcontrib><creatorcontrib>Valverde, Daniel</creatorcontrib><creatorcontrib>Capellades, Jaume</creatorcontrib><creatorcontrib>Cabañas, Miquel E</creatorcontrib><creatorcontrib>Ribera, Josep-Maria</creatorcontrib><creatorcontrib>Arús, Carles</creatorcontrib><title>In vivo quantification of response to treatment in patients with multiple myeloma by 1H magnetic resonance spectroscopy of bone marrow</title><title>Magma (New York, N.Y.)</title><addtitle>MAGMA</addtitle><description>Magnetic resonance imaging (MRI) is the gold standard non-invasive technique to detect malignant disease in the bone marrow. Proton magnetic resonance spectroscopy (MRS) can be performed as a quick adjunct to routine spinal MRI. We performed proton MRS to patients with multiple myeloma (MM) at diagnosis and after treatment to investigate the possible correlation of MRS data with response to therapy.
Twenty-one patients with newly diagnosed MM underwent combined MRI/MRS explorations of a transverse center section in the fifth lumbar vertebral body. MRS was acquired with STEAM and 40 ms TE. Areas of unsuppressed water and lipid resonances were used to calculate the lipid-to-water ratio (LWR).
No association was detected between initial LWRs and the clinical characteristics of patients. Post treatment MRS was available in 16 patients of whom 11 (69%) presented an LWR increase, this included all complete responders (8/8, 100%, P = 0.012). A post-treatment LWR value equal to or larger than one is proposed as a non-invasive marker of complete response to treatment.
Only patients responding to treatment presented a significant increase in bone marrow LWR after therapy. MRS may provide an adequate quantification of response to chemotherapy in patients with MM.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Bone marrow</subject><subject>Bone Marrow - metabolism</subject><subject>Cancer</subject><subject>Female</subject><subject>Humans</subject><subject>Lipids - analysis</subject><subject>Lumbar Vertebrae - metabolism</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Multiple myeloma</subject><subject>Multiple Myeloma - diagnosis</subject><subject>Multiple Myeloma - drug therapy</subject><subject>Multiple Myeloma - metabolism</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Prognosis</subject><subject>Protons</subject><subject>Spectroscopy</subject><subject>Spectrum analysis</subject><subject>Spine</subject><subject>Treatment Outcome</subject><issn>0968-5243</issn><issn>1352-8661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkcFu3CAURVHVqpmm_YBsKtRFdm4ehgG8rKI2iRSpm3aNMH5uiGxwACeaH8h3F2tGqtQF4i7OvbzHJeSCwVcGoK4yA85FU-V22ka8ITvG922jpWRvyQ46qZt9K_gZ-ZDzI0DL9sDfkzOmRLV2bEde7wJ99s-RPq02FD96Z4uPgcaRJsxLDBlpibQktGXGUKgPdKlIlZm--PJA53UqfpmQzgec4mxpf6Dsls72T8Di3RYTgw0OaV7QlRSzi8the6CPobpsSvHlI3k32injp9N9Tn7_-P7r-ra5_3lzd_3tvnFMMda0PTDrpMJes66H3iEOnVUAw6h4pzWAk3wEWT-j012ruRzlgKPTTopBK-Dn5PKYu6T4tGIuZvbZ4TTZgHHNRoEQouUb-OU_8DGuKdTZTAtKasaEqhA7Qq5ulROOZkm-LnQwDMzWkDk2ZDa5NWRE9Xw-Ba_9jMM_x6kS_hc90o2M</recordid><startdate>200704</startdate><enddate>200704</enddate><creator>Oriol, Albert</creator><creator>Valverde, Daniel</creator><creator>Capellades, Jaume</creator><creator>Cabañas, Miquel E</creator><creator>Ribera, Josep-Maria</creator><creator>Arús, Carles</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TN</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H96</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>P5Z</scope><scope>P62</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>200704</creationdate><title>In vivo quantification of response to treatment in patients with multiple myeloma by 1H magnetic resonance spectroscopy of bone marrow</title><author>Oriol, Albert ; Valverde, Daniel ; Capellades, Jaume ; Cabañas, Miquel E ; Ribera, Josep-Maria ; Arús, Carles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1711-2b01ac67eb819b0bceed9a700df7398800c63f060729892836f6defc8c64d8703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Bone marrow</topic><topic>Bone Marrow - metabolism</topic><topic>Cancer</topic><topic>Female</topic><topic>Humans</topic><topic>Lipids - analysis</topic><topic>Lumbar Vertebrae - metabolism</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Multiple myeloma</topic><topic>Multiple Myeloma - diagnosis</topic><topic>Multiple Myeloma - drug therapy</topic><topic>Multiple Myeloma - metabolism</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Prognosis</topic><topic>Protons</topic><topic>Spectroscopy</topic><topic>Spectrum analysis</topic><topic>Spine</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oriol, Albert</creatorcontrib><creatorcontrib>Valverde, Daniel</creatorcontrib><creatorcontrib>Capellades, Jaume</creatorcontrib><creatorcontrib>Cabañas, Miquel E</creatorcontrib><creatorcontrib>Ribera, Josep-Maria</creatorcontrib><creatorcontrib>Arús, Carles</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oceanic Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 2: Ocean Technology, Policy & Non-Living Resources</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Magma (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oriol, Albert</au><au>Valverde, Daniel</au><au>Capellades, Jaume</au><au>Cabañas, Miquel E</au><au>Ribera, Josep-Maria</au><au>Arús, Carles</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo quantification of response to treatment in patients with multiple myeloma by 1H magnetic resonance spectroscopy of bone marrow</atitle><jtitle>Magma (New York, N.Y.)</jtitle><addtitle>MAGMA</addtitle><date>2007-04</date><risdate>2007</risdate><volume>20</volume><issue>2</issue><spage>93</spage><epage>101</epage><pages>93-101</pages><issn>0968-5243</issn><eissn>1352-8661</eissn><coden>MAGMEY</coden><abstract>Magnetic resonance imaging (MRI) is the gold standard non-invasive technique to detect malignant disease in the bone marrow. Proton magnetic resonance spectroscopy (MRS) can be performed as a quick adjunct to routine spinal MRI. We performed proton MRS to patients with multiple myeloma (MM) at diagnosis and after treatment to investigate the possible correlation of MRS data with response to therapy.
Twenty-one patients with newly diagnosed MM underwent combined MRI/MRS explorations of a transverse center section in the fifth lumbar vertebral body. MRS was acquired with STEAM and 40 ms TE. Areas of unsuppressed water and lipid resonances were used to calculate the lipid-to-water ratio (LWR).
No association was detected between initial LWRs and the clinical characteristics of patients. Post treatment MRS was available in 16 patients of whom 11 (69%) presented an LWR increase, this included all complete responders (8/8, 100%, P = 0.012). A post-treatment LWR value equal to or larger than one is proposed as a non-invasive marker of complete response to treatment.
Only patients responding to treatment presented a significant increase in bone marrow LWR after therapy. MRS may provide an adequate quantification of response to chemotherapy in patients with MM.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>17410391</pmid><doi>10.1007/s10334-007-0072-4</doi><tpages>9</tpages></addata></record> |
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subjects | Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - administration & dosage Biomarkers, Tumor - analysis Bone marrow Bone Marrow - metabolism Cancer Female Humans Lipids - analysis Lumbar Vertebrae - metabolism Magnetic Resonance Spectroscopy - methods Male Medical imaging Middle Aged Multiple myeloma Multiple Myeloma - diagnosis Multiple Myeloma - drug therapy Multiple Myeloma - metabolism NMR Nuclear magnetic resonance Prognosis Protons Spectroscopy Spectrum analysis Spine Treatment Outcome |
title | In vivo quantification of response to treatment in patients with multiple myeloma by 1H magnetic resonance spectroscopy of bone marrow |
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