Synthesis and structure–activity relationships of thiadiazole-derivatives as potent and orally active peroxisome proliferator-activated receptors α/δ dual agonists

Using PPARδ selective agonist (GW501516) as the lead, we conducted the structure–activity relationship study and identified the [1,2,4]thiadiazole-derivatives as potent and orally active peroxisome proliferators-activated receptors α/δ dual agonists. Replacement of the methyl-thiazole moiety of GW50...

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