Synthesis and Structure of 1,4-Dipiperazino Benzenes:  Chiral Terphenyl-type Peptide Helix Mimetics

The terphenyl structure has been proven to be an ideal scaffold mimicking side-chain functionalities of peptidic α-helices. The synthesis of 1,4-dipiperazino benzenes, using stepwise transition metal-catalyzed N-arylation of chiral piperazines to a central benzene core is reported. The structure det...

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Veröffentlicht in:	Organic letters 2008-04, Vol.10 (7), p.1473-1476
Hauptverfasser:	Maity, Prantik, König, Burkhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzene Derivatives - chemical synthesis Benzene Derivatives - chemistry Crystallography, X-Ray Molecular Conformation Molecular Mimicry Molecular Structure Peptides - chemistry Protein Structure, Secondary Terphenyl Compounds - chemistry
Online-Zugang:	Volltext
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