Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study
Summary Background Dengue viruses are a major cause of morbidity and mortality in tropical and subtropical areas. Our aim was to assess prospectively the burden of dengue-related illness in children in Thailand. Methods We did a prospective study in a cohort of children at primary school in northern...
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| Veröffentlicht in: | The Lancet (British edition) 2007-04, Vol.369 (9571), p.1452-1459 |
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| creator | Anderson, Katie B, MSPH Chunsuttiwat, Supamit, MD Nisalak, Ananda, MD Mammen, Mammen P, MD Libraty, Daniel H, MD Rothman, Alan L, MD Green, Sharone, MD Vaughn, David W, MD Ennis, Francis A, MD Endy, Timothy P, Dr |
| description | Summary Background Dengue viruses are a major cause of morbidity and mortality in tropical and subtropical areas. Our aim was to assess prospectively the burden of dengue-related illness in children in Thailand. Methods We did a prospective study in a cohort of children at primary school in northern Thailand from 1998 to 2002. We assessed the burden of dengue illness as disability-adjusted life years (DALYs) and patient costs per illness. Findings Dengue accounted for 328 (11%) of the 3056 febrile cases identified in 2114 children during the study period. The mean burden of dengue was 465·3 (SD 358·0; range 76·5–954·0) DALYs per million population per year, accounting for about 15% of DALYs lost to all febrile illnesses (3213·1 [SD 2624·2] DALYs per million per year). Non-hospitalised patients with dengue illnesses represented a substantial proportion of the overall burden of disease, with 44–73% of the total DALYs lost to dengue each year due to such illness. The infecting dengue serotype was an important determinant of DALYs lost: DEN4 was responsible for 1% of total DALYs lost, DEN1 for 9%, DEN2 for 30%, and DEN3 for 29%. Interpretation Use of prospective data to estimate the burden of disease shows that most DALYs lost to dengue illness were the result of non-hospitalised illnesses of long duration. Thus, inclusion of non-hospitalised cases is critical to accurately assess the total burden of dengue illness. |
| doi_str_mv | 10.1016/S0140-6736(07)60671-0 |
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Our aim was to assess prospectively the burden of dengue-related illness in children in Thailand. Methods We did a prospective study in a cohort of children at primary school in northern Thailand from 1998 to 2002. We assessed the burden of dengue illness as disability-adjusted life years (DALYs) and patient costs per illness. Findings Dengue accounted for 328 (11%) of the 3056 febrile cases identified in 2114 children during the study period. The mean burden of dengue was 465·3 (SD 358·0; range 76·5–954·0) DALYs per million population per year, accounting for about 15% of DALYs lost to all febrile illnesses (3213·1 [SD 2624·2] DALYs per million per year). Non-hospitalised patients with dengue illnesses represented a substantial proportion of the overall burden of disease, with 44–73% of the total DALYs lost to dengue each year due to such illness. The infecting dengue serotype was an important determinant of DALYs lost: DEN4 was responsible for 1% of total DALYs lost, DEN1 for 9%, DEN2 for 30%, and DEN3 for 29%. Interpretation Use of prospective data to estimate the burden of disease shows that most DALYs lost to dengue illness were the result of non-hospitalised illnesses of long duration. Thus, inclusion of non-hospitalised cases is critical to accurately assess the total burden of dengue illness.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(07)60671-0</identifier><identifier>PMID: 17467515</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Acquired immune deficiency syndrome ; Adolescent ; Age ; AIDS ; Blood transfusions ; Child ; Child, Preschool ; Children ; Children & youth ; Communicable Diseases - complications ; Communicable Diseases - epidemiology ; Cost of Illness ; Costs ; Dengue - classification ; Dengue - economics ; Dengue - epidemiology ; Dengue fever ; Elementary schools ; Female ; Fever ; Health risk assessment ; Hepatitis ; Hospitals ; Humans ; Illnesses ; Incidence ; Infections ; Internal Medicine ; Laboratories ; Male ; Morbidity ; Population ; Population Surveillance ; Prospective Studies ; Regulatory agencies ; Review boards ; Severe Dengue - classification ; Severe Dengue - economics ; Severe Dengue - epidemiology ; Severity of Illness Index ; Thailand - epidemiology ; Tropical diseases ; Vector-borne diseases ; Viral diseases ; Viruses</subject><ispartof>The Lancet (British edition), 2007-04, Vol.369 (9571), p.1452-1459</ispartof><rights>Elsevier Ltd</rights><rights>2007 Elsevier Ltd</rights><rights>Copyright Elsevier Limited Apr 28-May 4, 2007</rights><rights>Copyright Elsevier Limited Apr 28, 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-ae9d04584276faa94b409dc0c09f518b88a7954b717393e16cb286ca05e1421f3</citedby><cites>FETCH-LOGICAL-c473t-ae9d04584276faa94b409dc0c09f518b88a7954b717393e16cb286ca05e1421f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0140673607606710$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17467515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anderson, Katie B, MSPH</creatorcontrib><creatorcontrib>Chunsuttiwat, Supamit, MD</creatorcontrib><creatorcontrib>Nisalak, Ananda, MD</creatorcontrib><creatorcontrib>Mammen, Mammen P, MD</creatorcontrib><creatorcontrib>Libraty, Daniel H, MD</creatorcontrib><creatorcontrib>Rothman, Alan L, MD</creatorcontrib><creatorcontrib>Green, Sharone, MD</creatorcontrib><creatorcontrib>Vaughn, David W, MD</creatorcontrib><creatorcontrib>Ennis, Francis A, MD</creatorcontrib><creatorcontrib>Endy, Timothy P, Dr</creatorcontrib><title>Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Summary Background Dengue viruses are a major cause of morbidity and mortality in tropical and subtropical areas. Our aim was to assess prospectively the burden of dengue-related illness in children in Thailand. Methods We did a prospective study in a cohort of children at primary school in northern Thailand from 1998 to 2002. We assessed the burden of dengue illness as disability-adjusted life years (DALYs) and patient costs per illness. Findings Dengue accounted for 328 (11%) of the 3056 febrile cases identified in 2114 children during the study period. The mean burden of dengue was 465·3 (SD 358·0; range 76·5–954·0) DALYs per million population per year, accounting for about 15% of DALYs lost to all febrile illnesses (3213·1 [SD 2624·2] DALYs per million per year). Non-hospitalised patients with dengue illnesses represented a substantial proportion of the overall burden of disease, with 44–73% of the total DALYs lost to dengue each year due to such illness. The infecting dengue serotype was an important determinant of DALYs lost: DEN4 was responsible for 1% of total DALYs lost, DEN1 for 9%, DEN2 for 30%, and DEN3 for 29%. Interpretation Use of prospective data to estimate the burden of disease shows that most DALYs lost to dengue illness were the result of non-hospitalised illnesses of long duration. Thus, inclusion of non-hospitalised cases is critical to accurately assess the total burden of dengue illness.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adolescent</subject><subject>Age</subject><subject>AIDS</subject><subject>Blood transfusions</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Communicable Diseases - complications</subject><subject>Communicable Diseases - epidemiology</subject><subject>Cost of Illness</subject><subject>Costs</subject><subject>Dengue - classification</subject><subject>Dengue - economics</subject><subject>Dengue - epidemiology</subject><subject>Dengue fever</subject><subject>Elementary schools</subject><subject>Female</subject><subject>Fever</subject><subject>Health risk 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MSPH</au><au>Chunsuttiwat, Supamit, MD</au><au>Nisalak, Ananda, MD</au><au>Mammen, Mammen P, MD</au><au>Libraty, Daniel H, MD</au><au>Rothman, Alan L, MD</au><au>Green, Sharone, MD</au><au>Vaughn, David W, MD</au><au>Ennis, Francis A, MD</au><au>Endy, Timothy P, Dr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>2007-04-28</date><risdate>2007</risdate><volume>369</volume><issue>9571</issue><spage>1452</spage><epage>1459</epage><pages>1452-1459</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Summary Background Dengue viruses are a major cause of morbidity and mortality in tropical and subtropical areas. Our aim was to assess prospectively the burden of dengue-related illness in children in Thailand. Methods We did a prospective study in a cohort of children at primary school in northern Thailand from 1998 to 2002. We assessed the burden of dengue illness as disability-adjusted life years (DALYs) and patient costs per illness. Findings Dengue accounted for 328 (11%) of the 3056 febrile cases identified in 2114 children during the study period. The mean burden of dengue was 465·3 (SD 358·0; range 76·5–954·0) DALYs per million population per year, accounting for about 15% of DALYs lost to all febrile illnesses (3213·1 [SD 2624·2] DALYs per million per year). Non-hospitalised patients with dengue illnesses represented a substantial proportion of the overall burden of disease, with 44–73% of the total DALYs lost to dengue each year due to such illness. The infecting dengue serotype was an important determinant of DALYs lost: DEN4 was responsible for 1% of total DALYs lost, DEN1 for 9%, DEN2 for 30%, and DEN3 for 29%. Interpretation Use of prospective data to estimate the burden of disease shows that most DALYs lost to dengue illness were the result of non-hospitalised illnesses of long duration. Thus, inclusion of non-hospitalised cases is critical to accurately assess the total burden of dengue illness.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>17467515</pmid><doi>10.1016/S0140-6736(07)60671-0</doi><tpages>8</tpages></addata></record> |
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| subjects | Acquired immune deficiency syndrome Adolescent Age AIDS Blood transfusions Child Child, Preschool Children Children & youth Communicable Diseases - complications Communicable Diseases - epidemiology Cost of Illness Costs Dengue - classification Dengue - economics Dengue - epidemiology Dengue fever Elementary schools Female Fever Health risk assessment Hepatitis Hospitals Humans Illnesses Incidence Infections Internal Medicine Laboratories Male Morbidity Population Population Surveillance Prospective Studies Regulatory agencies Review boards Severe Dengue - classification Severe Dengue - economics Severe Dengue - epidemiology Severity of Illness Index Thailand - epidemiology Tropical diseases Vector-borne diseases Viral diseases Viruses |
| title | Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study |
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