PICOT Attenuates Cardiac Hypertrophy by Disrupting Calcineurin–NFAT Signaling

PICOT (protein kinase C–interacting cousin of thioredoxin) was previously shown to inhibit pressure overload-induced cardiac hypertrophy, concomitant with an increase in ventricular function and cardiomyocyte contractility. The combined analyses of glutathione S-transferase pull-down experiments and...

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Veröffentlicht in:	Circulation research 2008-03, Vol.102 (6), p.711-719
Hauptverfasser:	Jeong, Dongtak, Kim, Ji Myoung, Cha, Hyeseon, Oh, Jae Gyun, Park, Jaeho, Yun, Soo-Hyeon, Ju, Eun-Seon, Jeon, Eun-Seok, Hajjar, Roger J, Park, Woo Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Animals Animals, Newborn Binding, Competitive Biological and medical sciences Calcineurin - metabolism Cardiomegaly - metabolism Cardiomegaly - pathology Cardiomegaly - prevention & control Cardiotonic Agents - pharmacology Cell Size Cells, Cultured Fundamental and applied biological sciences. Psychology LIM Domain Proteins Mechanotransduction, Cellular Mice Mice, Transgenic Muscle Proteins - genetics Muscle Proteins - metabolism Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Nerve Tissue Proteins - metabolism NFATC Transcription Factors - metabolism NIH 3T3 Cells Phenylephrine - pharmacology Phosphoric Monoester Hydrolases - metabolism Phosphorylation Protein Binding Protein Interaction Domains and Motifs Protein Structure, Tertiary Rats Rats, Sprague-Dawley Recombinant Fusion Proteins - metabolism Signal Transduction - drug effects Thioredoxins - chemistry Thioredoxins - genetics Thioredoxins - metabolism Transduction, Genetic Vertebrates: cardiovascular system
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