Reorganization of the Suprachiasmatic Nucleus Coding for Day Length
In mammals, the suprachiasmatic nucleus (SCN), the circadian pacemaker, receives light information via the retina and functions in the entrainment of circadian rhythms and in phasing the seasonal responses of behavioral and physiological functions. To better understand photoperiod-related alteration...
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| Veröffentlicht in: | Journal of biological rhythms 2008-04, Vol.23 (2), p.140-149 |
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| creator | Naito, Emiko Watanabe, Tsuyoshi Tei, Hajime Yoshimura, Takashi Ebihara, Shizufumi |
| description | In mammals, the suprachiasmatic nucleus (SCN), the circadian pacemaker, receives light information via the retina and functions in the entrainment of circadian rhythms and in phasing the seasonal responses of behavioral and physiological functions. To better understand photoperiod-related alterations in the SCN physiology, we analyzed the clock gene expression in the mouse SCN by performing in situ hybridization and real-time monitoring of the mPer1::luc bioluminescence. Under long photoperiod (LP) conditions, the expression rhythms of mPer1 and Bmal1 in the caudal SCN phase-led those in the rostral SCN; further, within the middle SCN, the rhythms in the ventrolateral (VL)--like subdivision advanced compared with those in the dorsomedial (DM)--like subdivision. The mPer1::luc rhythms in the entire coronal slice obtained from the middle SCN exhibited 2 peaks with a wide peak width under LP conditions. Imaging analysis of the mPer1::luc rhythms in several subdivisions of the rostral, middle, caudal, and horizontal SCN revealed wide regional variations in the peak time in the rostral half of the SCN under LP conditions. These variations were not due to alterations in the waveform of a single SCN neuronal rhythm. Our results indicate that LP conditions induce phase changes in the rhythms in multiple regions in the rostral half of the SCN; this leads to different circadian waveforms in the entire SCN, coding for day length. |
| doi_str_mv | 10.1177/0748730408314572 |
| format | Article |
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To better understand photoperiod-related alterations in the SCN physiology, we analyzed the clock gene expression in the mouse SCN by performing in situ hybridization and real-time monitoring of the mPer1::luc bioluminescence. Under long photoperiod (LP) conditions, the expression rhythms of mPer1 and Bmal1 in the caudal SCN phase-led those in the rostral SCN; further, within the middle SCN, the rhythms in the ventrolateral (VL)--like subdivision advanced compared with those in the dorsomedial (DM)--like subdivision. The mPer1::luc rhythms in the entire coronal slice obtained from the middle SCN exhibited 2 peaks with a wide peak width under LP conditions. Imaging analysis of the mPer1::luc rhythms in several subdivisions of the rostral, middle, caudal, and horizontal SCN revealed wide regional variations in the peak time in the rostral half of the SCN under LP conditions. These variations were not due to alterations in the waveform of a single SCN neuronal rhythm. Our results indicate that LP conditions induce phase changes in the rhythms in multiple regions in the rostral half of the SCN; this leads to different circadian waveforms in the entire SCN, coding for day length.</description><identifier>ISSN: 0748-7304</identifier><identifier>EISSN: 1552-4531</identifier><identifier>DOI: 10.1177/0748730408314572</identifier><identifier>PMID: 18375863</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Analysis ; Animals ; ARNTL Transcription Factors ; Basic Helix-Loop-Helix Transcription Factors - genetics ; Basic Helix-Loop-Helix Transcription Factors - metabolism ; Biological clocks ; Biological Clocks - physiology ; Bioluminescence ; BMAL1 protein ; Cell Cycle Proteins - genetics ; Cell Cycle Proteins - metabolism ; Circadian rhythm ; Circadian Rhythm - physiology ; Circadian rhythms ; Clock gene ; Entrainment ; Gene expression ; Genetic aspects ; Health aspects ; Horizontal cells ; In Situ Hybridization ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Motor Activity - physiology ; Neural coding ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Period 1 protein ; Period Circadian Proteins ; Phase transitions ; Photoperiod ; Physiological aspects ; Recombinant Fusion Proteins - genetics ; Recombinant Fusion Proteins - metabolism ; Retina ; Rhythm ; Subdivisions ; Suprachiasmatic nucleus ; Suprachiasmatic Nucleus - cytology ; Suprachiasmatic Nucleus - physiology ; Waveforms</subject><ispartof>Journal of biological rhythms, 2008-04, Vol.23 (2), p.140-149</ispartof><rights>COPYRIGHT 2008 Sage Publications, Inc.</rights><rights>Copyright SAGE PUBLICATIONS, INC. 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To better understand photoperiod-related alterations in the SCN physiology, we analyzed the clock gene expression in the mouse SCN by performing in situ hybridization and real-time monitoring of the mPer1::luc bioluminescence. Under long photoperiod (LP) conditions, the expression rhythms of mPer1 and Bmal1 in the caudal SCN phase-led those in the rostral SCN; further, within the middle SCN, the rhythms in the ventrolateral (VL)--like subdivision advanced compared with those in the dorsomedial (DM)--like subdivision. The mPer1::luc rhythms in the entire coronal slice obtained from the middle SCN exhibited 2 peaks with a wide peak width under LP conditions. Imaging analysis of the mPer1::luc rhythms in several subdivisions of the rostral, middle, caudal, and horizontal SCN revealed wide regional variations in the peak time in the rostral half of the SCN under LP conditions. These variations were not due to alterations in the waveform of a single SCN neuronal rhythm. Our results indicate that LP conditions induce phase changes in the rhythms in multiple regions in the rostral half of the SCN; this leads to different circadian waveforms in the entire SCN, coding for day length.</description><subject>Analysis</subject><subject>Animals</subject><subject>ARNTL Transcription Factors</subject><subject>Basic Helix-Loop-Helix Transcription Factors - genetics</subject><subject>Basic Helix-Loop-Helix Transcription Factors - metabolism</subject><subject>Biological clocks</subject><subject>Biological Clocks - physiology</subject><subject>Bioluminescence</subject><subject>BMAL1 protein</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - physiology</subject><subject>Circadian rhythms</subject><subject>Clock gene</subject><subject>Entrainment</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Horizontal cells</subject><subject>In Situ Hybridization</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Motor Activity - physiology</subject><subject>Neural coding</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Period 1 protein</subject><subject>Period Circadian Proteins</subject><subject>Phase transitions</subject><subject>Photoperiod</subject><subject>Physiological aspects</subject><subject>Recombinant Fusion Proteins - genetics</subject><subject>Recombinant Fusion Proteins - metabolism</subject><subject>Retina</subject><subject>Rhythm</subject><subject>Subdivisions</subject><subject>Suprachiasmatic nucleus</subject><subject>Suprachiasmatic Nucleus - cytology</subject><subject>Suprachiasmatic Nucleus - physiology</subject><subject>Waveforms</subject><issn>0748-7304</issn><issn>1552-4531</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1r3DAQxUVpabZp7z21hkJvTkaSpZGPYfsVWBpomrOQZdmrYFtbyT6kf321eKElUIJAgpnfG0bvEfKWwgWliJeAlUIOFShOK4HsGdlQIVhZCU6fk82xXR77Z-RVSvcAIOuKvyRnVHEUSvIN2f5wIfZm8r_N7MNUhK6Y9664XQ7R2L03acx1W3xf7OCWVGxD66e-6EIsPpmHYuemft6_Ji86MyT35vSek7svn39uv5W7m6_X26tdaYUUc1kZyYA2aARSgYaBY_nGphNY87oB2jJDjbDQOspprTq0DTYtcM5kU3PJz8nHde4hhl-LS7MefbJuGMzkwpI0QpWdEOxJkFGWHVMigx8egfdhiVP-hKY1UxShRp6pi5XqzeC0n7owZ3Pyad3obZhc53P9iqKUooYKswBWgY0hpeg6fYh-NPFBU9DH4PTj4LLk3WmTpRld-1dwSioD5Qok07t_1vz_wPcr35mgTR990ne32X8OoFAxWfM_PPul0w</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Naito, Emiko</creator><creator>Watanabe, Tsuyoshi</creator><creator>Tei, Hajime</creator><creator>Yoshimura, Takashi</creator><creator>Ebihara, Shizufumi</creator><general>SAGE Publications</general><general>Sage Publications, Inc</general><general>SAGE PUBLICATIONS, INC</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Reorganization of the Suprachiasmatic Nucleus Coding for Day Length</title><author>Naito, Emiko ; Watanabe, Tsuyoshi ; Tei, Hajime ; Yoshimura, Takashi ; Ebihara, Shizufumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-4a6201b7a57157a20e27a27bf57939b01d2a1a5c0de13198f7cb7bd03326b9363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>ARNTL Transcription Factors</topic><topic>Basic Helix-Loop-Helix Transcription Factors - genetics</topic><topic>Basic Helix-Loop-Helix Transcription Factors - metabolism</topic><topic>Biological clocks</topic><topic>Biological Clocks - physiology</topic><topic>Bioluminescence</topic><topic>BMAL1 protein</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Circadian rhythm</topic><topic>Circadian Rhythm - physiology</topic><topic>Circadian rhythms</topic><topic>Clock gene</topic><topic>Entrainment</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Horizontal cells</topic><topic>In Situ Hybridization</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>Motor Activity - physiology</topic><topic>Neural coding</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Period 1 protein</topic><topic>Period Circadian Proteins</topic><topic>Phase transitions</topic><topic>Photoperiod</topic><topic>Physiological aspects</topic><topic>Recombinant Fusion Proteins - genetics</topic><topic>Recombinant Fusion Proteins - metabolism</topic><topic>Retina</topic><topic>Rhythm</topic><topic>Subdivisions</topic><topic>Suprachiasmatic nucleus</topic><topic>Suprachiasmatic Nucleus - cytology</topic><topic>Suprachiasmatic Nucleus - physiology</topic><topic>Waveforms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naito, Emiko</creatorcontrib><creatorcontrib>Watanabe, Tsuyoshi</creatorcontrib><creatorcontrib>Tei, Hajime</creatorcontrib><creatorcontrib>Yoshimura, Takashi</creatorcontrib><creatorcontrib>Ebihara, Shizufumi</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biological rhythms</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naito, Emiko</au><au>Watanabe, Tsuyoshi</au><au>Tei, Hajime</au><au>Yoshimura, Takashi</au><au>Ebihara, Shizufumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reorganization of the Suprachiasmatic Nucleus Coding for Day Length</atitle><jtitle>Journal of biological rhythms</jtitle><addtitle>J Biol Rhythms</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>23</volume><issue>2</issue><spage>140</spage><epage>149</epage><pages>140-149</pages><issn>0748-7304</issn><eissn>1552-4531</eissn><abstract>In mammals, the suprachiasmatic nucleus (SCN), the circadian pacemaker, receives light information via the retina and functions in the entrainment of circadian rhythms and in phasing the seasonal responses of behavioral and physiological functions. To better understand photoperiod-related alterations in the SCN physiology, we analyzed the clock gene expression in the mouse SCN by performing in situ hybridization and real-time monitoring of the mPer1::luc bioluminescence. Under long photoperiod (LP) conditions, the expression rhythms of mPer1 and Bmal1 in the caudal SCN phase-led those in the rostral SCN; further, within the middle SCN, the rhythms in the ventrolateral (VL)--like subdivision advanced compared with those in the dorsomedial (DM)--like subdivision. The mPer1::luc rhythms in the entire coronal slice obtained from the middle SCN exhibited 2 peaks with a wide peak width under LP conditions. Imaging analysis of the mPer1::luc rhythms in several subdivisions of the rostral, middle, caudal, and horizontal SCN revealed wide regional variations in the peak time in the rostral half of the SCN under LP conditions. These variations were not due to alterations in the waveform of a single SCN neuronal rhythm. Our results indicate that LP conditions induce phase changes in the rhythms in multiple regions in the rostral half of the SCN; this leads to different circadian waveforms in the entire SCN, coding for day length.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>18375863</pmid><doi>10.1177/0748730408314572</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Animals ARNTL Transcription Factors Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Biological clocks Biological Clocks - physiology Bioluminescence BMAL1 protein Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Circadian rhythm Circadian Rhythm - physiology Circadian rhythms Clock gene Entrainment Gene expression Genetic aspects Health aspects Horizontal cells In Situ Hybridization Mice Mice, Inbred C57BL Mice, Transgenic Motor Activity - physiology Neural coding Nuclear Proteins - genetics Nuclear Proteins - metabolism Period 1 protein Period Circadian Proteins Phase transitions Photoperiod Physiological aspects Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Retina Rhythm Subdivisions Suprachiasmatic nucleus Suprachiasmatic Nucleus - cytology Suprachiasmatic Nucleus - physiology Waveforms |
| title | Reorganization of the Suprachiasmatic Nucleus Coding for Day Length |
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