PI3K activates negative and positive signals to regulate TRB3 expression in hepatic cells

TRB3 is a pseudokinase whose expression is regulated during stress response and changing of nutrient status. TRB3 negatively regulates Akt activation and noticeably, TRB3 expression is induced by insulin. Here, we sought to determine the dynamic relationship between TRB3 expression and Akt activatio...

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Veröffentlicht in:	Experimental cell research 2008-04, Vol.314 (7), p.1566-1574
Hauptverfasser:	Ding, Jixin, Kato, Satomi, Du, Keyong
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Akt atypical PKC Animals Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cellular biology Enzyme Activation - drug effects Hepatocytes - drug effects Hepatocytes - enzymology Hepatocytes - metabolism Humans Insulin Insulin - pharmacology Insulin gene expression Kinases Liver Mice Organ Specificity - drug effects P13K Phosphatidylinositol 3-Kinases - metabolism Promoter Regions, Genetic - genetics Protein Kinase C - metabolism Proto-Oncogene Proteins c-akt - metabolism Signal transduction Signal Transduction - drug effects TRB3
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