Differential gene expression analysis of iodide-treated rat thyroid follicular cell line PCCl3

The inhibitory effect of supraphysiological iodide concentrations on thyroid hormone synthesis (Wolff–Chaikoff effect) and on thyrocyte proliferation is largely known as iodine autoregulation. However, the molecular mechanisms by which iodide modulates thyroid function remain unclear. In this paper,...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 2008-04, Vol.91 (4), p.356-366
Hauptverfasser:	Leoni, S.G., Galante, P.A., Ricarte-Filho, J.C.M., Kimura, E.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoregulation Base Sequence Cell Line Differential gene expression Gene Expression Profiling Iodides - pharmacology Iodine Iodine excess Methimazole PCCl3 lineage Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics SAGE Thyroid Thyroid differentiation Thyroid Gland - cytology Thyroid Gland - drug effects Thyroid Gland - metabolism Transcriptome
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