Locoregional IL-2 Therapy in the Treatment of Colon Cancer. Cell-induced Lesions of a Murine Model
Background: Local therapy with IL-2 may be very effective in the treatment of different forms of cancer. The aim of this study was to determine the effectiveness of IL-2 locoregional application in the treatment of colon cancer. Materials and Methods: Twenty eight syngenic BDIX rats were utilized in...
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| Veröffentlicht in: | Anticancer research 2007-03, Vol.27 (2), p.985-989 |
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| creator | CAPORALE, A BRESCIA, A SCARPINI, M COSENZA, U. M GALATI, G CASTELLI, M SAPUTO, S TERRENATO, I CUCINA, A LIVERANI, A GASPARRINI, M CIARDI, A |
| description | Background: Local therapy with IL-2 may be very effective in the treatment of different forms of cancer. The aim of this study
was to determine the effectiveness of IL-2 locoregional application in the treatment of colon cancer. Materials and Methods:
Twenty eight syngenic BDIX rats were utilized in this study. The rats were divided into two groups of fourteen animals: group
T (treatment) and group C (control). All rats of both groups were injected, under the splenic capsule, with T 10 7 DHD/K12/ TRb neoplastic cells. Then, within and around the site of the previous inoculation, the T group was injected with
1 ml of glucosate solutions + 0.1% albumin (BSA) containing 2.5Ã10 6 IU of IL-2 (Proleukin-Chiron), whereas the C group was injected with 1 ml of BSA alone. After three weeks, rats were sacrificed
and the liver and spleen were removed. The following parameters were considered: volume and weight, neoplastic-non neoplastic
tissue index of the spleen, mitotic index and vascular density of splenic and hepatic lesions. Results: All the studied parameters
showed statistically significant differences in treated and untreated animals. Conclusion: This study of a murine model demonstrated
that IL-2 locoregional therapy may be effective in the treatment of colon cancer. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_70439737</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70439737</sourcerecordid><originalsourceid>FETCH-LOGICAL-h299t-8bd6659b6ff538d1ca26f901afee698cc200acb177461f238c4286aa76bffbdc3</originalsourceid><addsrcrecordid>eNqF0EtLxDAUBeAiio6PvyBZqLtKHtOkWUrxBRU347rcpjc2kjZj0iL-eyuOuHR1Nh-Hw9nLVkxplqtC0P1sRXlBc0VpcZQdp_RGqZS6FIfZEVNrWXDBVllbBxMivrowgiePdc7JpscI20_iRjL1SDYRYRpwnEiwpAo-jKSC0WC8JhV6n7uxmw12pMa0lKRvBeRpjm5E8hQ69KfZgQWf8GyXJ9nL3e2mesjr5_vH6qbOe671lJdtJ2WhW2ltIcqOGeDSasrAIi6zjeGUgmmZWrYzy0Vp1ryUAEq21radESfZ1U_vNob3GdPUDC6ZZSKMGObUKLoWWgn1L2Rack31NzzfwbkdsGu20Q0QP5vf-xZwuQOQDHgbl2Nc-nOlLJRkcnEXP653r_2Hi9ikAbxfakUDkauGN7osxBfET4VK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19629097</pqid></control><display><type>article</type><title>Locoregional IL-2 Therapy in the Treatment of Colon Cancer. Cell-induced Lesions of a Murine Model</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>CAPORALE, A ; BRESCIA, A ; SCARPINI, M ; COSENZA, U. M ; GALATI, G ; CASTELLI, M ; SAPUTO, S ; TERRENATO, I ; CUCINA, A ; LIVERANI, A ; GASPARRINI, M ; CIARDI, A</creator><creatorcontrib>CAPORALE, A ; BRESCIA, A ; SCARPINI, M ; COSENZA, U. M ; GALATI, G ; CASTELLI, M ; SAPUTO, S ; TERRENATO, I ; CUCINA, A ; LIVERANI, A ; GASPARRINI, M ; CIARDI, A</creatorcontrib><description>Background: Local therapy with IL-2 may be very effective in the treatment of different forms of cancer. The aim of this study
was to determine the effectiveness of IL-2 locoregional application in the treatment of colon cancer. Materials and Methods:
Twenty eight syngenic BDIX rats were utilized in this study. The rats were divided into two groups of fourteen animals: group
T (treatment) and group C (control). All rats of both groups were injected, under the splenic capsule, with T 10 7 DHD/K12/ TRb neoplastic cells. Then, within and around the site of the previous inoculation, the T group was injected with
1 ml of glucosate solutions + 0.1% albumin (BSA) containing 2.5Ã10 6 IU of IL-2 (Proleukin-Chiron), whereas the C group was injected with 1 ml of BSA alone. After three weeks, rats were sacrificed
and the liver and spleen were removed. The following parameters were considered: volume and weight, neoplastic-non neoplastic
tissue index of the spleen, mitotic index and vascular density of splenic and hepatic lesions. Results: All the studied parameters
showed statistically significant differences in treated and untreated animals. Conclusion: This study of a murine model demonstrated
that IL-2 locoregional therapy may be effective in the treatment of colon cancer.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 17465231</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Animals ; Biological and medical sciences ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - pathology ; Gastroenterology. Liver. Pancreas. Abdomen ; Interleukin-2 - pharmacology ; Liver Neoplasms, Experimental - prevention & control ; Liver Neoplasms, Experimental - secondary ; Medical sciences ; Mice ; Neoplasm Transplantation ; Rats ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors ; Xenograft Model Antitumor Assays</subject><ispartof>Anticancer research, 2007-03, Vol.27 (2), p.985-989</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18657616$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17465231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CAPORALE, A</creatorcontrib><creatorcontrib>BRESCIA, A</creatorcontrib><creatorcontrib>SCARPINI, M</creatorcontrib><creatorcontrib>COSENZA, U. M</creatorcontrib><creatorcontrib>GALATI, G</creatorcontrib><creatorcontrib>CASTELLI, M</creatorcontrib><creatorcontrib>SAPUTO, S</creatorcontrib><creatorcontrib>TERRENATO, I</creatorcontrib><creatorcontrib>CUCINA, A</creatorcontrib><creatorcontrib>LIVERANI, A</creatorcontrib><creatorcontrib>GASPARRINI, M</creatorcontrib><creatorcontrib>CIARDI, A</creatorcontrib><title>Locoregional IL-2 Therapy in the Treatment of Colon Cancer. Cell-induced Lesions of a Murine Model</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: Local therapy with IL-2 may be very effective in the treatment of different forms of cancer. The aim of this study
was to determine the effectiveness of IL-2 locoregional application in the treatment of colon cancer. Materials and Methods:
Twenty eight syngenic BDIX rats were utilized in this study. The rats were divided into two groups of fourteen animals: group
T (treatment) and group C (control). All rats of both groups were injected, under the splenic capsule, with T 10 7 DHD/K12/ TRb neoplastic cells. Then, within and around the site of the previous inoculation, the T group was injected with
1 ml of glucosate solutions + 0.1% albumin (BSA) containing 2.5Ã10 6 IU of IL-2 (Proleukin-Chiron), whereas the C group was injected with 1 ml of BSA alone. After three weeks, rats were sacrificed
and the liver and spleen were removed. The following parameters were considered: volume and weight, neoplastic-non neoplastic
tissue index of the spleen, mitotic index and vascular density of splenic and hepatic lesions. Results: All the studied parameters
showed statistically significant differences in treated and untreated animals. Conclusion: This study of a murine model demonstrated
that IL-2 locoregional therapy may be effective in the treatment of colon cancer.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Interleukin-2 - pharmacology</subject><subject>Liver Neoplasms, Experimental - prevention & control</subject><subject>Liver Neoplasms, Experimental - secondary</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Neoplasm Transplantation</subject><subject>Rats</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EtLxDAUBeAiio6PvyBZqLtKHtOkWUrxBRU347rcpjc2kjZj0iL-eyuOuHR1Nh-Hw9nLVkxplqtC0P1sRXlBc0VpcZQdp_RGqZS6FIfZEVNrWXDBVllbBxMivrowgiePdc7JpscI20_iRjL1SDYRYRpwnEiwpAo-jKSC0WC8JhV6n7uxmw12pMa0lKRvBeRpjm5E8hQ69KfZgQWf8GyXJ9nL3e2mesjr5_vH6qbOe671lJdtJ2WhW2ltIcqOGeDSasrAIi6zjeGUgmmZWrYzy0Vp1ryUAEq21radESfZ1U_vNob3GdPUDC6ZZSKMGObUKLoWWgn1L2Rack31NzzfwbkdsGu20Q0QP5vf-xZwuQOQDHgbl2Nc-nOlLJRkcnEXP653r_2Hi9ikAbxfakUDkauGN7osxBfET4VK</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>CAPORALE, A</creator><creator>BRESCIA, A</creator><creator>SCARPINI, M</creator><creator>COSENZA, U. M</creator><creator>GALATI, G</creator><creator>CASTELLI, M</creator><creator>SAPUTO, S</creator><creator>TERRENATO, I</creator><creator>CUCINA, A</creator><creator>LIVERANI, A</creator><creator>GASPARRINI, M</creator><creator>CIARDI, A</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>Locoregional IL-2 Therapy in the Treatment of Colon Cancer. Cell-induced Lesions of a Murine Model</title><author>CAPORALE, A ; BRESCIA, A ; SCARPINI, M ; COSENZA, U. M ; GALATI, G ; CASTELLI, M ; SAPUTO, S ; TERRENATO, I ; CUCINA, A ; LIVERANI, A ; GASPARRINI, M ; CIARDI, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h299t-8bd6659b6ff538d1ca26f901afee698cc200acb177461f238c4286aa76bffbdc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Interleukin-2 - pharmacology</topic><topic>Liver Neoplasms, Experimental - prevention & control</topic><topic>Liver Neoplasms, Experimental - secondary</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Neoplasm Transplantation</topic><topic>Rats</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CAPORALE, A</creatorcontrib><creatorcontrib>BRESCIA, A</creatorcontrib><creatorcontrib>SCARPINI, M</creatorcontrib><creatorcontrib>COSENZA, U. M</creatorcontrib><creatorcontrib>GALATI, G</creatorcontrib><creatorcontrib>CASTELLI, M</creatorcontrib><creatorcontrib>SAPUTO, S</creatorcontrib><creatorcontrib>TERRENATO, I</creatorcontrib><creatorcontrib>CUCINA, A</creatorcontrib><creatorcontrib>LIVERANI, A</creatorcontrib><creatorcontrib>GASPARRINI, M</creatorcontrib><creatorcontrib>CIARDI, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CAPORALE, A</au><au>BRESCIA, A</au><au>SCARPINI, M</au><au>COSENZA, U. M</au><au>GALATI, G</au><au>CASTELLI, M</au><au>SAPUTO, S</au><au>TERRENATO, I</au><au>CUCINA, A</au><au>LIVERANI, A</au><au>GASPARRINI, M</au><au>CIARDI, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Locoregional IL-2 Therapy in the Treatment of Colon Cancer. Cell-induced Lesions of a Murine Model</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>27</volume><issue>2</issue><spage>985</spage><epage>989</epage><pages>985-989</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: Local therapy with IL-2 may be very effective in the treatment of different forms of cancer. The aim of this study
was to determine the effectiveness of IL-2 locoregional application in the treatment of colon cancer. Materials and Methods:
Twenty eight syngenic BDIX rats were utilized in this study. The rats were divided into two groups of fourteen animals: group
T (treatment) and group C (control). All rats of both groups were injected, under the splenic capsule, with T 10 7 DHD/K12/ TRb neoplastic cells. Then, within and around the site of the previous inoculation, the T group was injected with
1 ml of glucosate solutions + 0.1% albumin (BSA) containing 2.5Ã10 6 IU of IL-2 (Proleukin-Chiron), whereas the C group was injected with 1 ml of BSA alone. After three weeks, rats were sacrificed
and the liver and spleen were removed. The following parameters were considered: volume and weight, neoplastic-non neoplastic
tissue index of the spleen, mitotic index and vascular density of splenic and hepatic lesions. Results: All the studied parameters
showed statistically significant differences in treated and untreated animals. Conclusion: This study of a murine model demonstrated
that IL-2 locoregional therapy may be effective in the treatment of colon cancer.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>17465231</pmid><tpages>5</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Gastroenterology. Liver. Pancreas. Abdomen Interleukin-2 - pharmacology Liver Neoplasms, Experimental - prevention & control Liver Neoplasms, Experimental - secondary Medical sciences Mice Neoplasm Transplantation Rats Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Xenograft Model Antitumor Assays |
| title | Locoregional IL-2 Therapy in the Treatment of Colon Cancer. Cell-induced Lesions of a Murine Model |
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