Prevalence of some risk factors in children with epilepsy compared to their controls
Summary Aim The goal of this case–control study was to identify the significance of certain risk factors for epilepsy in Turkey. Method A total of 805 cases, aged 1–16 years, followed-up for epilepsy at the Pediatric Neurology Department and a control group consisting of 846 age-matched cases withou...
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creator | Cansu, Ali Serdaroğlu, Ayşe Yüksel, Deniz Doğan, Vehbi Özkan, Seçil Hırfanoğlu, Tuğba Şenbil, Nesrin Gücüyener, Kıvılcım Soysal, Şebnem Çamurdan, Aysu Gürer, Yavuz Kemal |
description | Summary Aim The goal of this case–control study was to identify the significance of certain risk factors for epilepsy in Turkey. Method A total of 805 cases, aged 1–16 years, followed-up for epilepsy at the Pediatric Neurology Department and a control group consisting of 846 age-matched cases without epilepsy were included in the study. The risk factors examined were gender, neurological impairment, febrile convulsion, head trauma, central nervous system infections, parental consanguinity, family history of epilepsy, prenatal and natal risk and newborn jaundice. Data regarding the investigated epilepsy risk factors were obtained through a questionnaire via personal interviews and the medical records and were assessed using univariate and multivariate analysis. Result Univariate analysis showed an increased risk for epilepsy with a history of atypical febrile seizure (21.97-fold), severe and moderate head injury (27.76- and 7.09-fold respectively), CNS infection (4.76-fold), history of epilepsy in first-, second- or third-degree relatives (6.42-, 3.09- and 2.66-fold, respectively), presence of maternal hypertension (4.31-fold), an apgar score ≤6 at any time (7.78-fold) and neonatal jaundice (3.12-fold). Abnormal neurological signs increased the epilepsy risk 5.92 times in univariate analysis and 30.26 times in multivariate analysis. Conclusion The most important risk factors for epilepsy in this study were neurological impairment, history of atypical febrile seizures, severe head injury and a low apgar score. Other important risk factors were moderate head trauma and a history of epilepsy in the family. |
doi_str_mv | 10.1016/j.seizure.2007.02.003 |
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Method A total of 805 cases, aged 1–16 years, followed-up for epilepsy at the Pediatric Neurology Department and a control group consisting of 846 age-matched cases without epilepsy were included in the study. The risk factors examined were gender, neurological impairment, febrile convulsion, head trauma, central nervous system infections, parental consanguinity, family history of epilepsy, prenatal and natal risk and newborn jaundice. Data regarding the investigated epilepsy risk factors were obtained through a questionnaire via personal interviews and the medical records and were assessed using univariate and multivariate analysis. Result Univariate analysis showed an increased risk for epilepsy with a history of atypical febrile seizure (21.97-fold), severe and moderate head injury (27.76- and 7.09-fold respectively), CNS infection (4.76-fold), history of epilepsy in first-, second- or third-degree relatives (6.42-, 3.09- and 2.66-fold, respectively), presence of maternal hypertension (4.31-fold), an apgar score ≤6 at any time (7.78-fold) and neonatal jaundice (3.12-fold). Abnormal neurological signs increased the epilepsy risk 5.92 times in univariate analysis and 30.26 times in multivariate analysis. Conclusion The most important risk factors for epilepsy in this study were neurological impairment, history of atypical febrile seizures, severe head injury and a low apgar score. Other important risk factors were moderate head trauma and a history of epilepsy in the family.</description><identifier>ISSN: 1059-1311</identifier><identifier>EISSN: 1532-2688</identifier><identifier>DOI: 10.1016/j.seizure.2007.02.003</identifier><identifier>PMID: 17391991</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Apgar Score ; Case-Control Studies ; Child ; Child, Preschool ; Children ; Craniocerebral Trauma - complications ; Epilepsy ; Epilepsy - epidemiology ; Epilepsy - etiology ; Female ; Genetic Predisposition to Disease ; Humans ; Infant ; Infant, Newborn ; Male ; Nervous System Diseases - complications ; Neurology ; Prevalence ; Risk Factors ; Seizures, Febrile - complications ; Turkey</subject><ispartof>Seizure (London, England), 2007-06, Vol.16 (4), p.338-344</ispartof><rights>British Epilepsy Association</rights><rights>2007 British Epilepsy Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-5b467996309c68b62578decae89cc92a45f46244c1c2a9e1ebee846f63a690983</citedby><cites>FETCH-LOGICAL-c465t-5b467996309c68b62578decae89cc92a45f46244c1c2a9e1ebee846f63a690983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.seizure.2007.02.003$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17391991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cansu, Ali</creatorcontrib><creatorcontrib>Serdaroğlu, Ayşe</creatorcontrib><creatorcontrib>Yüksel, Deniz</creatorcontrib><creatorcontrib>Doğan, Vehbi</creatorcontrib><creatorcontrib>Özkan, Seçil</creatorcontrib><creatorcontrib>Hırfanoğlu, Tuğba</creatorcontrib><creatorcontrib>Şenbil, Nesrin</creatorcontrib><creatorcontrib>Gücüyener, Kıvılcım</creatorcontrib><creatorcontrib>Soysal, Şebnem</creatorcontrib><creatorcontrib>Çamurdan, Aysu</creatorcontrib><creatorcontrib>Gürer, Yavuz Kemal</creatorcontrib><title>Prevalence of some risk factors in children with epilepsy compared to their controls</title><title>Seizure (London, England)</title><addtitle>Seizure</addtitle><description>Summary Aim The goal of this case–control study was to identify the significance of certain risk factors for epilepsy in Turkey. Method A total of 805 cases, aged 1–16 years, followed-up for epilepsy at the Pediatric Neurology Department and a control group consisting of 846 age-matched cases without epilepsy were included in the study. The risk factors examined were gender, neurological impairment, febrile convulsion, head trauma, central nervous system infections, parental consanguinity, family history of epilepsy, prenatal and natal risk and newborn jaundice. Data regarding the investigated epilepsy risk factors were obtained through a questionnaire via personal interviews and the medical records and were assessed using univariate and multivariate analysis. Result Univariate analysis showed an increased risk for epilepsy with a history of atypical febrile seizure (21.97-fold), severe and moderate head injury (27.76- and 7.09-fold respectively), CNS infection (4.76-fold), history of epilepsy in first-, second- or third-degree relatives (6.42-, 3.09- and 2.66-fold, respectively), presence of maternal hypertension (4.31-fold), an apgar score ≤6 at any time (7.78-fold) and neonatal jaundice (3.12-fold). Abnormal neurological signs increased the epilepsy risk 5.92 times in univariate analysis and 30.26 times in multivariate analysis. Conclusion The most important risk factors for epilepsy in this study were neurological impairment, history of atypical febrile seizures, severe head injury and a low apgar score. Other important risk factors were moderate head trauma and a history of epilepsy in the family.</description><subject>Adolescent</subject><subject>Apgar Score</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Craniocerebral Trauma - complications</subject><subject>Epilepsy</subject><subject>Epilepsy - epidemiology</subject><subject>Epilepsy - etiology</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Nervous System Diseases - complications</subject><subject>Neurology</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Seizures, Febrile - complications</subject><subject>Turkey</subject><issn>1059-1311</issn><issn>1532-2688</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9r3DAQxUVoaZJtP0KKTr3Z1T_L1qUhhKQpBBpoCr0JrTxmtZEtR7ITNp--MrsQyCWnGYb3ZpjfQ-iMkpISKr9vywTuZY5QMkLqkrCSEH6ETmjFWcFk03zIPalUQTmlx-g0pS0hRAnKP6FjWnNFlaIn6P4uwpPxMFjAocMp9ICjSw-4M3YKMWE3YLtxvo0w4Gc3bTCMzsOYdtiGfjQRWjwFPG3AxTwZphh8-ow-dsYn-HKoK_T3-ur-8qa4_f3z1-XFbWGFrKaiWgtZKyU5UVY2a8mqumnBGmiUtYoZUXVCMiEstcwooLAGaITsJDdSEdXwFfq23zvG8DhDmnTvkgXvzQBhTromgqsqc1mhai-0MaQUodNjdL2JO02JXnDqrT7g1AtOTZjOtuz7ejgwr3toX10HfllwvhdAfvPJQdTJugVm6yLYSbfBvXvix5sN1rvBWeMfYAdpG-Y4ZIaa6pQN-s-S6RIpqXOcgv_j_wHRQ56k</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Cansu, Ali</creator><creator>Serdaroğlu, Ayşe</creator><creator>Yüksel, Deniz</creator><creator>Doğan, Vehbi</creator><creator>Özkan, Seçil</creator><creator>Hırfanoğlu, Tuğba</creator><creator>Şenbil, Nesrin</creator><creator>Gücüyener, Kıvılcım</creator><creator>Soysal, Şebnem</creator><creator>Çamurdan, Aysu</creator><creator>Gürer, Yavuz Kemal</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070601</creationdate><title>Prevalence of some risk factors in children with epilepsy compared to their controls</title><author>Cansu, Ali ; Serdaroğlu, Ayşe ; Yüksel, Deniz ; Doğan, Vehbi ; Özkan, Seçil ; Hırfanoğlu, Tuğba ; Şenbil, Nesrin ; Gücüyener, Kıvılcım ; Soysal, Şebnem ; Çamurdan, Aysu ; Gürer, Yavuz Kemal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-5b467996309c68b62578decae89cc92a45f46244c1c2a9e1ebee846f63a690983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Apgar Score</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Craniocerebral Trauma - complications</topic><topic>Epilepsy</topic><topic>Epilepsy - epidemiology</topic><topic>Epilepsy - etiology</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Nervous System Diseases - complications</topic><topic>Neurology</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Seizures, Febrile - complications</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cansu, Ali</creatorcontrib><creatorcontrib>Serdaroğlu, Ayşe</creatorcontrib><creatorcontrib>Yüksel, Deniz</creatorcontrib><creatorcontrib>Doğan, Vehbi</creatorcontrib><creatorcontrib>Özkan, Seçil</creatorcontrib><creatorcontrib>Hırfanoğlu, Tuğba</creatorcontrib><creatorcontrib>Şenbil, Nesrin</creatorcontrib><creatorcontrib>Gücüyener, Kıvılcım</creatorcontrib><creatorcontrib>Soysal, Şebnem</creatorcontrib><creatorcontrib>Çamurdan, Aysu</creatorcontrib><creatorcontrib>Gürer, Yavuz Kemal</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seizure (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cansu, Ali</au><au>Serdaroğlu, Ayşe</au><au>Yüksel, Deniz</au><au>Doğan, Vehbi</au><au>Özkan, Seçil</au><au>Hırfanoğlu, Tuğba</au><au>Şenbil, Nesrin</au><au>Gücüyener, Kıvılcım</au><au>Soysal, Şebnem</au><au>Çamurdan, Aysu</au><au>Gürer, Yavuz Kemal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of some risk factors in children with epilepsy compared to their controls</atitle><jtitle>Seizure (London, England)</jtitle><addtitle>Seizure</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>16</volume><issue>4</issue><spage>338</spage><epage>344</epage><pages>338-344</pages><issn>1059-1311</issn><eissn>1532-2688</eissn><abstract>Summary Aim The goal of this case–control study was to identify the significance of certain risk factors for epilepsy in Turkey. Method A total of 805 cases, aged 1–16 years, followed-up for epilepsy at the Pediatric Neurology Department and a control group consisting of 846 age-matched cases without epilepsy were included in the study. The risk factors examined were gender, neurological impairment, febrile convulsion, head trauma, central nervous system infections, parental consanguinity, family history of epilepsy, prenatal and natal risk and newborn jaundice. Data regarding the investigated epilepsy risk factors were obtained through a questionnaire via personal interviews and the medical records and were assessed using univariate and multivariate analysis. Result Univariate analysis showed an increased risk for epilepsy with a history of atypical febrile seizure (21.97-fold), severe and moderate head injury (27.76- and 7.09-fold respectively), CNS infection (4.76-fold), history of epilepsy in first-, second- or third-degree relatives (6.42-, 3.09- and 2.66-fold, respectively), presence of maternal hypertension (4.31-fold), an apgar score ≤6 at any time (7.78-fold) and neonatal jaundice (3.12-fold). Abnormal neurological signs increased the epilepsy risk 5.92 times in univariate analysis and 30.26 times in multivariate analysis. Conclusion The most important risk factors for epilepsy in this study were neurological impairment, history of atypical febrile seizures, severe head injury and a low apgar score. Other important risk factors were moderate head trauma and a history of epilepsy in the family.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>17391991</pmid><doi>10.1016/j.seizure.2007.02.003</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Apgar Score Case-Control Studies Child Child, Preschool Children Craniocerebral Trauma - complications Epilepsy Epilepsy - epidemiology Epilepsy - etiology Female Genetic Predisposition to Disease Humans Infant Infant, Newborn Male Nervous System Diseases - complications Neurology Prevalence Risk Factors Seizures, Febrile - complications Turkey |
title | Prevalence of some risk factors in children with epilepsy compared to their controls |
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