Pregnancy at or beyond age 40 years is associated with an increased risk of fetal death and other adverse outcomes
Objective The objective of the study was to determine the frequency of fetal death in women 40 years of age or older (AMA). Study Design Retrospective study of all singleton pregnancies delivered at our institution between the years 1989 and 2004 was performed. The primary outcome measure was the ri...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2007-05, Vol.196 (5), p.e11-e13 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 196 |
| creator | Hoffman, M. Camille, MD Jeffers, Sarah, MD Carter, Jena, MD Duthely, Lunthita, MS Cotter, Amanda, MD González-Quintero, Víctor Hugo, MD, MPH |
| description | Objective The objective of the study was to determine the frequency of fetal death in women 40 years of age or older (AMA). Study Design Retrospective study of all singleton pregnancies delivered at our institution between the years 1989 and 2004 was performed. The primary outcome measure was the risk of fetal death at various gestational ages. We also investigated the frequency of maternal comorbidities, preterm delivery (PTD), and low and very low birth weights (LBW, VLBW). Results Data were available for 126,402 singleton deliveries. AMA was an independent risk factor for fetal death at 28-31 weeks (adjusted odds ratio [AOR] 2.93, 95% confidence interval [CI] 1.76-4.92), 32-36 (AOR 1.73, 95% CI 1.05-2.83), 37-39 weeks (AOR 1.63, 95% CI 0.97-2.75), and 40-41 weeks (AOR 2.28, 95% CI 1.18-4.4). AMA was associated with increased rates of PTD, LBW, and VLBW. Conclusion AMA is associated with an increased rate of fetal death and other adverse obstetrical outcomes. Antepartum fetal surveillance may be warranted in these women. |
| doi_str_mv | 10.1016/j.ajog.2006.10.862 |
| format | Article |
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Camille, MD ; Jeffers, Sarah, MD ; Carter, Jena, MD ; Duthely, Lunthita, MS ; Cotter, Amanda, MD ; González-Quintero, Víctor Hugo, MD, MPH</creator><creatorcontrib>Hoffman, M. Camille, MD ; Jeffers, Sarah, MD ; Carter, Jena, MD ; Duthely, Lunthita, MS ; Cotter, Amanda, MD ; González-Quintero, Víctor Hugo, MD, MPH</creatorcontrib><description>Objective The objective of the study was to determine the frequency of fetal death in women 40 years of age or older (AMA). Study Design Retrospective study of all singleton pregnancies delivered at our institution between the years 1989 and 2004 was performed. The primary outcome measure was the risk of fetal death at various gestational ages. We also investigated the frequency of maternal comorbidities, preterm delivery (PTD), and low and very low birth weights (LBW, VLBW). Results Data were available for 126,402 singleton deliveries. AMA was an independent risk factor for fetal death at 28-31 weeks (adjusted odds ratio [AOR] 2.93, 95% confidence interval [CI] 1.76-4.92), 32-36 (AOR 1.73, 95% CI 1.05-2.83), 37-39 weeks (AOR 1.63, 95% CI 0.97-2.75), and 40-41 weeks (AOR 2.28, 95% CI 1.18-4.4). AMA was associated with increased rates of PTD, LBW, and VLBW. Conclusion AMA is associated with an increased rate of fetal death and other adverse obstetrical outcomes. Antepartum fetal surveillance may be warranted in these women.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2006.10.862</identifier><identifier>PMID: 17466664</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Adult ; advanced maternal age ; Age Factors ; antepartum fetal surveillance ; Comorbidity ; Female ; fetal death ; Fetal Death - etiology ; Gestational Age ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Maternal Age ; Obstetrics and Gynecology ; Pregnancy ; Pregnancy Outcome ; Premature Birth ; Retrospective Studies ; Risk Factors</subject><ispartof>American journal of obstetrics and gynecology, 2007-05, Vol.196 (5), p.e11-e13</ispartof><rights>Mosby, Inc.</rights><rights>2007 Mosby, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-b2781e3a69bf6cfe1fa0f749fb19f2aa08fbd024c2a2765bcb2e85bec21190c73</citedby><cites>FETCH-LOGICAL-c409t-b2781e3a69bf6cfe1fa0f749fb19f2aa08fbd024c2a2765bcb2e85bec21190c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002937806021272$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17466664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoffman, M. Camille, MD</creatorcontrib><creatorcontrib>Jeffers, Sarah, MD</creatorcontrib><creatorcontrib>Carter, Jena, MD</creatorcontrib><creatorcontrib>Duthely, Lunthita, MS</creatorcontrib><creatorcontrib>Cotter, Amanda, MD</creatorcontrib><creatorcontrib>González-Quintero, Víctor Hugo, MD, MPH</creatorcontrib><title>Pregnancy at or beyond age 40 years is associated with an increased risk of fetal death and other adverse outcomes</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective The objective of the study was to determine the frequency of fetal death in women 40 years of age or older (AMA). Study Design Retrospective study of all singleton pregnancies delivered at our institution between the years 1989 and 2004 was performed. The primary outcome measure was the risk of fetal death at various gestational ages. We also investigated the frequency of maternal comorbidities, preterm delivery (PTD), and low and very low birth weights (LBW, VLBW). Results Data were available for 126,402 singleton deliveries. AMA was an independent risk factor for fetal death at 28-31 weeks (adjusted odds ratio [AOR] 2.93, 95% confidence interval [CI] 1.76-4.92), 32-36 (AOR 1.73, 95% CI 1.05-2.83), 37-39 weeks (AOR 1.63, 95% CI 0.97-2.75), and 40-41 weeks (AOR 2.28, 95% CI 1.18-4.4). AMA was associated with increased rates of PTD, LBW, and VLBW. Conclusion AMA is associated with an increased rate of fetal death and other adverse obstetrical outcomes. Antepartum fetal surveillance may be warranted in these women.</description><subject>Adult</subject><subject>advanced maternal age</subject><subject>Age Factors</subject><subject>antepartum fetal surveillance</subject><subject>Comorbidity</subject><subject>Female</subject><subject>fetal death</subject><subject>Fetal Death - etiology</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Maternal Age</subject><subject>Obstetrics and Gynecology</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Premature Birth</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVGL1TAQhYMo7nX1D_ggefKt10naTVoQQRZ1FxYU1OcwTSd30-1t1ky7y_33tt4Lgg_OS5jDOQfyjRCvFWwVKPOu32KfdlsNYBZhWxv9RGwUNLYwtamfig0A6KIpbX0mXjD366ob_VycKVuZZaqNyN8y7UYc_UHiJFOWLR3S2EnckaxAHggzy8gSmZOPOFEnH-N0K3GUcfSZkBclR76TKchAEw6yI_xj6GSabilL7B4oM8k0Tz7tiV-KZwEHplen91z8_Pzpx-VVcfP1y_Xlx5vCV9BMRattrahE07TB-EAqIARbNaFVTdCIUIe2A115jdqai9a3muqLlrxWqgFvy3Px9th7n9OvmXhy-8iehgFHSjM7C1VpjS4Xoz4afU7MmYK7z3GP-eAUuJW0691K2q2kV20hvYTenNrndk_d38gJ7WJ4fzTQ8seHSNmxjzR66mImP7kuxf_3f_gn7oc4Ro_DHR2I-zTncaHnlGPtwH1fj7ueGgxopa0ufwPdw6Vv</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Hoffman, M. Camille, MD</creator><creator>Jeffers, Sarah, MD</creator><creator>Carter, Jena, MD</creator><creator>Duthely, Lunthita, MS</creator><creator>Cotter, Amanda, MD</creator><creator>González-Quintero, Víctor Hugo, MD, MPH</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Pregnancy at or beyond age 40 years is associated with an increased risk of fetal death and other adverse outcomes</title><author>Hoffman, M. Camille, MD ; Jeffers, Sarah, MD ; Carter, Jena, MD ; Duthely, Lunthita, MS ; Cotter, Amanda, MD ; González-Quintero, Víctor Hugo, MD, MPH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-b2781e3a69bf6cfe1fa0f749fb19f2aa08fbd024c2a2765bcb2e85bec21190c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>advanced maternal age</topic><topic>Age Factors</topic><topic>antepartum fetal surveillance</topic><topic>Comorbidity</topic><topic>Female</topic><topic>fetal death</topic><topic>Fetal Death - etiology</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Maternal Age</topic><topic>Obstetrics and Gynecology</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Premature Birth</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoffman, M. Camille, MD</creatorcontrib><creatorcontrib>Jeffers, Sarah, MD</creatorcontrib><creatorcontrib>Carter, Jena, MD</creatorcontrib><creatorcontrib>Duthely, Lunthita, MS</creatorcontrib><creatorcontrib>Cotter, Amanda, MD</creatorcontrib><creatorcontrib>González-Quintero, Víctor Hugo, MD, MPH</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoffman, M. Camille, MD</au><au>Jeffers, Sarah, MD</au><au>Carter, Jena, MD</au><au>Duthely, Lunthita, MS</au><au>Cotter, Amanda, MD</au><au>González-Quintero, Víctor Hugo, MD, MPH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy at or beyond age 40 years is associated with an increased risk of fetal death and other adverse outcomes</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>196</volume><issue>5</issue><spage>e11</spage><epage>e13</epage><pages>e11-e13</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>Objective The objective of the study was to determine the frequency of fetal death in women 40 years of age or older (AMA). Study Design Retrospective study of all singleton pregnancies delivered at our institution between the years 1989 and 2004 was performed. The primary outcome measure was the risk of fetal death at various gestational ages. We also investigated the frequency of maternal comorbidities, preterm delivery (PTD), and low and very low birth weights (LBW, VLBW). Results Data were available for 126,402 singleton deliveries. AMA was an independent risk factor for fetal death at 28-31 weeks (adjusted odds ratio [AOR] 2.93, 95% confidence interval [CI] 1.76-4.92), 32-36 (AOR 1.73, 95% CI 1.05-2.83), 37-39 weeks (AOR 1.63, 95% CI 0.97-2.75), and 40-41 weeks (AOR 2.28, 95% CI 1.18-4.4). AMA was associated with increased rates of PTD, LBW, and VLBW. Conclusion AMA is associated with an increased rate of fetal death and other adverse obstetrical outcomes. Antepartum fetal surveillance may be warranted in these women.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>17466664</pmid><doi>10.1016/j.ajog.2006.10.862</doi></addata></record> |
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| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 2007-05, Vol.196 (5), p.e11-e13 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult advanced maternal age Age Factors antepartum fetal surveillance Comorbidity Female fetal death Fetal Death - etiology Gestational Age Humans Infant, Low Birth Weight Infant, Newborn Maternal Age Obstetrics and Gynecology Pregnancy Pregnancy Outcome Premature Birth Retrospective Studies Risk Factors |
| title | Pregnancy at or beyond age 40 years is associated with an increased risk of fetal death and other adverse outcomes |
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