HER2 Status and Benefit from Adjuvant Trastuzumab in Breast Cancer

To the Editor: Trastuzumab, an antibody against the protein product of the human epidermal growth factor receptor type 2 ( HER2 ) gene, improves progression-free survival and overall survival when added to chemotherapy in patients with metastatic breast cancer. 1 Initial trials enrolled patients wit...

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Veröffentlicht in:	The New England journal of medicine 2008-03, Vol.358 (13), p.1409-1411
Hauptverfasser:	Paik, Soonmyung, Kim, Chungyeul, Wolmark, Norman
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Antineoplastic Agents - therapeutic use Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Chemotherapy, Adjuvant Female Gene Amplification Genes, erbB-2 Humans Receptor, ErbB-2 - genetics Receptor, ErbB-2 - immunology Receptor, ErbB-2 - metabolism RNA, Messenger - metabolism Trastuzumab
Online-Zugang:	Volltext
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