Low HDL levels and the risk of death, sepsis and malignancy
Background High density lipoprotein (HDL) plays an important role as an anti-atherogenic molecule, but also possesses anti-inflammatory and anti-angiogenic properties. The effect of extremely low levels of HDL on the risk of sepsis and malignancy were therefore examined. Methods A retrospective anal...
Gespeichert in:
| Veröffentlicht in: | Clinical research in cardiology 2008-04, Vol.97 (4), p.227-233 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 233 |
|---|---|
| container_issue | 4 |
| container_start_page | 227 |
| container_title | Clinical research in cardiology |
| container_volume | 97 |
| creator | Shor, Renana Wainstein, Julio Oz, David Boaz, Mona Matas, Zipora Fux, Asora Halabe, Aaron |
| description | Background
High density lipoprotein (HDL) plays an important role as an anti-atherogenic molecule, but also possesses anti-inflammatory and anti-angiogenic properties. The effect of extremely low levels of HDL on the risk of sepsis and malignancy were therefore examined.
Methods
A retrospective analysis of patients hospitalized at the Edith Wolfson Medical center was conducted. Patients were divided into Group 1: 108 patients with serum HDL levels ≤20 mg/dl. Group 2: 96 patients with serum HDL levels ≥65 mg/dl. Medical history and laboratory data was recorded.
Results
The mean HDL levels in Group 1 were 16.1 ± 33 mg/dl compared to 74.9 ± 12.6 mg/dl in Group 2. Using a multivariate logistic regression analysis, low HDL was inversely associated with death (OR 0.96, 95% 0.93–0.99,
P
= 0.02), 3.98 fold increase in odds of fever (OR 3.98, 95% CI 1.3–11.8,
P
= 0.01), and 6.7-fold increase in the risk of cancer (OR 6.68, 95% CI 1.8–24.5,
P
= 0.004). HDL serum levels were inversely associated with sepsis. For each 1 mg/dl increase in HDL, a relative 11% decrease in odds of sepsis was observed (OR 0.886, 95% CI 0.8–0.976,
P
= 0.01).
Conclusions
Extremely low serum HDL levels (≤20 mg/dl) are associated with an increased risk of death, sepsis and malignancy. |
| doi_str_mv | 10.1007/s00392-007-0611-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70436743</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70436743</sourcerecordid><originalsourceid>FETCH-LOGICAL-c435t-fac4e4219d04be2b517167383a698accf204db62db2c43c9918a1ed97a3aa5dd3</originalsourceid><addsrcrecordid>eNp1kEtPwzAQhC0EoqXwA7ggiwMnAutHEkecUHlKkbjA2XJsp03Jo8QJqP31uKSiEhKnndV-M7YGoVMCVwQgvnYALKGBlwFEhATrPTQmIiJ-S-j-rxZ8hI6cWwCEBBg_RCMiIAIWh2N0kzZf-OkuxaX9tKXDqja4m1vcFu4dNzk2VnXzS-zs0hXDtVJlMatVrVfH6CBXpbMn2zlBbw_3r9OnIH15fJ7epoHmLOyCXGluOSWJAZ5ZmoUkJlHMBFNRIpTWOQVusoiajHqDThIiFLEmiRVTKjSGTdDFkLtsm4_euk5WhdO2LFVtm97JGDiLYs48eP4HXDR9W_u_SSFC4CB-IDJAum2ca20ul21RqXYlCchNrXKoVW7kpla59p6zbXCfVdbsHNsePUAHwPlTPbPt7uX_U78BJpCBBQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>885040843</pqid></control><display><type>article</type><title>Low HDL levels and the risk of death, sepsis and malignancy</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Shor, Renana ; Wainstein, Julio ; Oz, David ; Boaz, Mona ; Matas, Zipora ; Fux, Asora ; Halabe, Aaron</creator><creatorcontrib>Shor, Renana ; Wainstein, Julio ; Oz, David ; Boaz, Mona ; Matas, Zipora ; Fux, Asora ; Halabe, Aaron</creatorcontrib><description>Background
High density lipoprotein (HDL) plays an important role as an anti-atherogenic molecule, but also possesses anti-inflammatory and anti-angiogenic properties. The effect of extremely low levels of HDL on the risk of sepsis and malignancy were therefore examined.
Methods
A retrospective analysis of patients hospitalized at the Edith Wolfson Medical center was conducted. Patients were divided into Group 1: 108 patients with serum HDL levels ≤20 mg/dl. Group 2: 96 patients with serum HDL levels ≥65 mg/dl. Medical history and laboratory data was recorded.
Results
The mean HDL levels in Group 1 were 16.1 ± 33 mg/dl compared to 74.9 ± 12.6 mg/dl in Group 2. Using a multivariate logistic regression analysis, low HDL was inversely associated with death (OR 0.96, 95% 0.93–0.99,
P
= 0.02), 3.98 fold increase in odds of fever (OR 3.98, 95% CI 1.3–11.8,
P
= 0.01), and 6.7-fold increase in the risk of cancer (OR 6.68, 95% CI 1.8–24.5,
P
= 0.004). HDL serum levels were inversely associated with sepsis. For each 1 mg/dl increase in HDL, a relative 11% decrease in odds of sepsis was observed (OR 0.886, 95% CI 0.8–0.976,
P
= 0.01).
Conclusions
Extremely low serum HDL levels (≤20 mg/dl) are associated with an increased risk of death, sepsis and malignancy.</description><identifier>ISSN: 1861-0684</identifier><identifier>EISSN: 1861-0692</identifier><identifier>DOI: 10.1007/s00392-007-0611-z</identifier><identifier>PMID: 18060375</identifier><language>eng</language><publisher>Dordrecht: D. Steinkopff-Verlag</publisher><subject>Aged ; Aged, 80 and over ; Cardiology ; Comorbidity ; Female ; Fever - epidemiology ; Fever - metabolism ; Humans ; Hypolipoproteinemias - diagnosis ; Hypolipoproteinemias - epidemiology ; Hypolipoproteinemias - metabolism ; Lipoproteins, HDL - blood ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasms - epidemiology ; Neoplasms - metabolism ; Odds Ratio ; Original Paper ; Prognosis ; Regression analysis ; Retrospective Studies ; Risk Assessment ; Sepsis ; Sepsis - epidemiology ; Sepsis - metabolism ; Survival Rate</subject><ispartof>Clinical research in cardiology, 2008-04, Vol.97 (4), p.227-233</ispartof><rights>Springer-Verlag 2007</rights><rights>2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-fac4e4219d04be2b517167383a698accf204db62db2c43c9918a1ed97a3aa5dd3</citedby><cites>FETCH-LOGICAL-c435t-fac4e4219d04be2b517167383a698accf204db62db2c43c9918a1ed97a3aa5dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00392-007-0611-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00392-007-0611-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18060375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shor, Renana</creatorcontrib><creatorcontrib>Wainstein, Julio</creatorcontrib><creatorcontrib>Oz, David</creatorcontrib><creatorcontrib>Boaz, Mona</creatorcontrib><creatorcontrib>Matas, Zipora</creatorcontrib><creatorcontrib>Fux, Asora</creatorcontrib><creatorcontrib>Halabe, Aaron</creatorcontrib><title>Low HDL levels and the risk of death, sepsis and malignancy</title><title>Clinical research in cardiology</title><addtitle>Clin Res Cardiol</addtitle><addtitle>Clin Res Cardiol</addtitle><description>Background
High density lipoprotein (HDL) plays an important role as an anti-atherogenic molecule, but also possesses anti-inflammatory and anti-angiogenic properties. The effect of extremely low levels of HDL on the risk of sepsis and malignancy were therefore examined.
Methods
A retrospective analysis of patients hospitalized at the Edith Wolfson Medical center was conducted. Patients were divided into Group 1: 108 patients with serum HDL levels ≤20 mg/dl. Group 2: 96 patients with serum HDL levels ≥65 mg/dl. Medical history and laboratory data was recorded.
Results
The mean HDL levels in Group 1 were 16.1 ± 33 mg/dl compared to 74.9 ± 12.6 mg/dl in Group 2. Using a multivariate logistic regression analysis, low HDL was inversely associated with death (OR 0.96, 95% 0.93–0.99,
P
= 0.02), 3.98 fold increase in odds of fever (OR 3.98, 95% CI 1.3–11.8,
P
= 0.01), and 6.7-fold increase in the risk of cancer (OR 6.68, 95% CI 1.8–24.5,
P
= 0.004). HDL serum levels were inversely associated with sepsis. For each 1 mg/dl increase in HDL, a relative 11% decrease in odds of sepsis was observed (OR 0.886, 95% CI 0.8–0.976,
P
= 0.01).
Conclusions
Extremely low serum HDL levels (≤20 mg/dl) are associated with an increased risk of death, sepsis and malignancy.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cardiology</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Fever - epidemiology</subject><subject>Fever - metabolism</subject><subject>Humans</subject><subject>Hypolipoproteinemias - diagnosis</subject><subject>Hypolipoproteinemias - epidemiology</subject><subject>Hypolipoproteinemias - metabolism</subject><subject>Lipoproteins, HDL - blood</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasms - epidemiology</subject><subject>Neoplasms - metabolism</subject><subject>Odds Ratio</subject><subject>Original Paper</subject><subject>Prognosis</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Sepsis</subject><subject>Sepsis - epidemiology</subject><subject>Sepsis - metabolism</subject><subject>Survival Rate</subject><issn>1861-0684</issn><issn>1861-0692</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kEtPwzAQhC0EoqXwA7ggiwMnAutHEkecUHlKkbjA2XJsp03Jo8QJqP31uKSiEhKnndV-M7YGoVMCVwQgvnYALKGBlwFEhATrPTQmIiJ-S-j-rxZ8hI6cWwCEBBg_RCMiIAIWh2N0kzZf-OkuxaX9tKXDqja4m1vcFu4dNzk2VnXzS-zs0hXDtVJlMatVrVfH6CBXpbMn2zlBbw_3r9OnIH15fJ7epoHmLOyCXGluOSWJAZ5ZmoUkJlHMBFNRIpTWOQVusoiajHqDThIiFLEmiRVTKjSGTdDFkLtsm4_euk5WhdO2LFVtm97JGDiLYs48eP4HXDR9W_u_SSFC4CB-IDJAum2ca20ul21RqXYlCchNrXKoVW7kpla59p6zbXCfVdbsHNsePUAHwPlTPbPt7uX_U78BJpCBBQ</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Shor, Renana</creator><creator>Wainstein, Julio</creator><creator>Oz, David</creator><creator>Boaz, Mona</creator><creator>Matas, Zipora</creator><creator>Fux, Asora</creator><creator>Halabe, Aaron</creator><general>D. Steinkopff-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Low HDL levels and the risk of death, sepsis and malignancy</title><author>Shor, Renana ; Wainstein, Julio ; Oz, David ; Boaz, Mona ; Matas, Zipora ; Fux, Asora ; Halabe, Aaron</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-fac4e4219d04be2b517167383a698accf204db62db2c43c9918a1ed97a3aa5dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cardiology</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Fever - epidemiology</topic><topic>Fever - metabolism</topic><topic>Humans</topic><topic>Hypolipoproteinemias - diagnosis</topic><topic>Hypolipoproteinemias - epidemiology</topic><topic>Hypolipoproteinemias - metabolism</topic><topic>Lipoproteins, HDL - blood</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasms - epidemiology</topic><topic>Neoplasms - metabolism</topic><topic>Odds Ratio</topic><topic>Original Paper</topic><topic>Prognosis</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Sepsis</topic><topic>Sepsis - epidemiology</topic><topic>Sepsis - metabolism</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shor, Renana</creatorcontrib><creatorcontrib>Wainstein, Julio</creatorcontrib><creatorcontrib>Oz, David</creatorcontrib><creatorcontrib>Boaz, Mona</creatorcontrib><creatorcontrib>Matas, Zipora</creatorcontrib><creatorcontrib>Fux, Asora</creatorcontrib><creatorcontrib>Halabe, Aaron</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical research in cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shor, Renana</au><au>Wainstein, Julio</au><au>Oz, David</au><au>Boaz, Mona</au><au>Matas, Zipora</au><au>Fux, Asora</au><au>Halabe, Aaron</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low HDL levels and the risk of death, sepsis and malignancy</atitle><jtitle>Clinical research in cardiology</jtitle><stitle>Clin Res Cardiol</stitle><addtitle>Clin Res Cardiol</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>97</volume><issue>4</issue><spage>227</spage><epage>233</epage><pages>227-233</pages><issn>1861-0684</issn><eissn>1861-0692</eissn><abstract>Background
High density lipoprotein (HDL) plays an important role as an anti-atherogenic molecule, but also possesses anti-inflammatory and anti-angiogenic properties. The effect of extremely low levels of HDL on the risk of sepsis and malignancy were therefore examined.
Methods
A retrospective analysis of patients hospitalized at the Edith Wolfson Medical center was conducted. Patients were divided into Group 1: 108 patients with serum HDL levels ≤20 mg/dl. Group 2: 96 patients with serum HDL levels ≥65 mg/dl. Medical history and laboratory data was recorded.
Results
The mean HDL levels in Group 1 were 16.1 ± 33 mg/dl compared to 74.9 ± 12.6 mg/dl in Group 2. Using a multivariate logistic regression analysis, low HDL was inversely associated with death (OR 0.96, 95% 0.93–0.99,
P
= 0.02), 3.98 fold increase in odds of fever (OR 3.98, 95% CI 1.3–11.8,
P
= 0.01), and 6.7-fold increase in the risk of cancer (OR 6.68, 95% CI 1.8–24.5,
P
= 0.004). HDL serum levels were inversely associated with sepsis. For each 1 mg/dl increase in HDL, a relative 11% decrease in odds of sepsis was observed (OR 0.886, 95% CI 0.8–0.976,
P
= 0.01).
Conclusions
Extremely low serum HDL levels (≤20 mg/dl) are associated with an increased risk of death, sepsis and malignancy.</abstract><cop>Dordrecht</cop><pub>D. Steinkopff-Verlag</pub><pmid>18060375</pmid><doi>10.1007/s00392-007-0611-z</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1861-0684 |
| ispartof | Clinical research in cardiology, 2008-04, Vol.97 (4), p.227-233 |
| issn | 1861-0684 1861-0692 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70436743 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Aged, 80 and over Cardiology Comorbidity Female Fever - epidemiology Fever - metabolism Humans Hypolipoproteinemias - diagnosis Hypolipoproteinemias - epidemiology Hypolipoproteinemias - metabolism Lipoproteins, HDL - blood Male Medical research Medicine Medicine & Public Health Middle Aged Neoplasms - epidemiology Neoplasms - metabolism Odds Ratio Original Paper Prognosis Regression analysis Retrospective Studies Risk Assessment Sepsis Sepsis - epidemiology Sepsis - metabolism Survival Rate |
| title | Low HDL levels and the risk of death, sepsis and malignancy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T17%3A19%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20HDL%20levels%20and%20the%20risk%20of%20death,%20sepsis%20and%20malignancy&rft.jtitle=Clinical%20research%20in%20cardiology&rft.au=Shor,%20Renana&rft.date=2008-04-01&rft.volume=97&rft.issue=4&rft.spage=227&rft.epage=233&rft.pages=227-233&rft.issn=1861-0684&rft.eissn=1861-0692&rft_id=info:doi/10.1007/s00392-007-0611-z&rft_dat=%3Cproquest_cross%3E70436743%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=885040843&rft_id=info:pmid/18060375&rfr_iscdi=true |