Design and Creation of New Nanomaterials for Therapeutic RNAi

RNA interference is an evolutionarily conserved gene-silencing phenomenon that shows great promise for developing new therapies. However, the development of small interfering RNA (siRNA)-based therapies needs to overcome two barriers and be able to (i) identify chemically stable and effective siRNA...

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Veröffentlicht in:	ACS chemical biology 2007-04, Vol.2 (4), p.237-241
Hauptverfasser:	Baigude, Huricha, McCarroll, Joshua, Yang, Chao-shun, Swain, Pamela M, Rana, Tariq M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins B - blood Apolipoproteins B - genetics Liver - metabolism Male Mice Mice, Inbred C57BL Nanoparticles - chemistry Nanoparticles - therapeutic use Peptide Fragments - blood Peptide Fragments - genetics RNA Interference RNA, Small Interfering - therapeutic use
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