Myosin IIA is required for neurite outgrowth inhibition produced by repulsive guidance molecule

Although myelin-associated neurite outgrowth inhibitors express their effects through RhoA/Rho-kinase, the downstream targets of Rho-kinase remain unknown. We examined the involvement of myosin II, which is one of the downstream targets of Rho-kinase, by using blebbistatin - a specific myosin II inh...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neurochemistry 2008-04, Vol.105 (1), p.113-126
Hauptverfasser:	Kubo, Takekazu, Endo, Mitsuharu, Hata, Katsuhiko, Taniguchi, Junko, Kitajo, Keiko, Tomura, Sayaka, Yamaguchi, Atsushi, Mueller, Bernhard K, Yamashita, Toshihide
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Animals, Newborn axon Biochemistry Biological and medical sciences Cells, Cultured Cerebellum - cytology Cerebrospinal fluid. Meninges. Spinal cord Female Fundamental and applied biological sciences. Psychology Heterocyclic Compounds, 4 or More Rings - pharmacology Immunoprecipitation - methods In Situ Nick-End Labeling - methods Inhibitor drugs Isolated neuron and nerve. Neuroglia Kinases Laminectomy - methods Medical sciences Membrane Glycoproteins - pharmacology myosin II Myosin Light Chains - metabolism Myosin Type II - physiology Nerve Tissue Proteins - pharmacology Nervous system (semeiology, syndromes) Neural Inhibition - drug effects Neural Inhibition - physiology Neurites - drug effects Neurites - physiology Neurology Neurons - cytology Phosphorylation Rats Rats, Wistar repulsive guidance molecule Rho rho-Associated Kinases - metabolism Rho-kinase Ribonucleic acid RNA RNA, Small Interfering - metabolism Rodents Spinal cord injuries spinal cord injury Transfection - methods Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!