Crosstalk of hedgehog and Wnt pathways in gastric cancer
Abstract Morphogenic signals like Hedgehog (Hh) and Wnt are reported to play critical roles in the progression of gastric cancer. We aimed to assess the relationship between Hh and Wnt signaling pathways. In 58 gastric cancer specimens, Wnt pathway activation was inversely correlated with Hh pathway...
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| Veröffentlicht in: | Cancer letters 2008-05, Vol.263 (1), p.145-156 |
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| container_title | Cancer letters |
| container_volume | 263 |
| creator | Yanai, Kosuke Nakamura, Masafumi Akiyoshi, Takashi Nagai, Shuntaro Wada, Junji Koga, Kenichiro Noshiro, Hirokazu Nagai, Eishi Tsuneyoshi, Masazumi Tanaka, Masao Katano, Mitsuo |
| description | Abstract Morphogenic signals like Hedgehog (Hh) and Wnt are reported to play critical roles in the progression of gastric cancer. We aimed to assess the relationship between Hh and Wnt signaling pathways. In 58 gastric cancer specimens, Wnt pathway activation was inversely correlated with Hh pathway activation. When AGS gastric cancer cells, in which Wnt signaling was constitutively active, were used as a target cell line, Gli1 overexpression suppressed Wnt transcriptional activity, nuclear β-catenin accumulation and proliferation of AGS cells. Knock-down of β-catenin by siRNA suppressed Wnt pathway activity and proliferation of AGS cells. Our data may provide some clues for the treatment of gastric cancer associated with Wnt signaling activation. |
| doi_str_mv | 10.1016/j.canlet.2007.12.030 |
| format | Article |
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We aimed to assess the relationship between Hh and Wnt signaling pathways. In 58 gastric cancer specimens, Wnt pathway activation was inversely correlated with Hh pathway activation. When AGS gastric cancer cells, in which Wnt signaling was constitutively active, were used as a target cell line, Gli1 overexpression suppressed Wnt transcriptional activity, nuclear β-catenin accumulation and proliferation of AGS cells. Knock-down of β-catenin by siRNA suppressed Wnt pathway activity and proliferation of AGS cells. Our data may provide some clues for the treatment of gastric cancer associated with Wnt signaling activation.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2007.12.030</identifier><identifier>PMID: 18243529</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Base Sequence ; DNA methylation ; DNA Primers ; Gastric cancer ; Gli1 ; Hedgehog Proteins - metabolism ; Hedgehog signaling ; Hematology, Oncology and Palliative Medicine ; Heparan sulfate ; Humans ; Immunohistochemistry ; Kinases ; Ligands ; Morphogenesis ; Mutation ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction ; Stomach Neoplasms - metabolism ; Surgery ; Wnt Proteins - metabolism ; Wnt signaling ; β-catenin</subject><ispartof>Cancer letters, 2008-05, Vol.263 (1), p.145-156</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2007 Elsevier Ireland Ltd</rights><rights>Copyright Elsevier Limited May 8, 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-c670b55be3a641809fd3dc6886ee6d004d2525865a5a030a6322e5b32f1fc8fc3</citedby><cites>FETCH-LOGICAL-c443t-c670b55be3a641809fd3dc6886ee6d004d2525865a5a030a6322e5b32f1fc8fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304383507006374$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18243529$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yanai, Kosuke</creatorcontrib><creatorcontrib>Nakamura, Masafumi</creatorcontrib><creatorcontrib>Akiyoshi, Takashi</creatorcontrib><creatorcontrib>Nagai, Shuntaro</creatorcontrib><creatorcontrib>Wada, Junji</creatorcontrib><creatorcontrib>Koga, Kenichiro</creatorcontrib><creatorcontrib>Noshiro, Hirokazu</creatorcontrib><creatorcontrib>Nagai, Eishi</creatorcontrib><creatorcontrib>Tsuneyoshi, Masazumi</creatorcontrib><creatorcontrib>Tanaka, Masao</creatorcontrib><creatorcontrib>Katano, Mitsuo</creatorcontrib><title>Crosstalk of hedgehog and Wnt pathways in gastric cancer</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Abstract Morphogenic signals like Hedgehog (Hh) and Wnt are reported to play critical roles in the progression of gastric cancer. We aimed to assess the relationship between Hh and Wnt signaling pathways. In 58 gastric cancer specimens, Wnt pathway activation was inversely correlated with Hh pathway activation. When AGS gastric cancer cells, in which Wnt signaling was constitutively active, were used as a target cell line, Gli1 overexpression suppressed Wnt transcriptional activity, nuclear β-catenin accumulation and proliferation of AGS cells. Knock-down of β-catenin by siRNA suppressed Wnt pathway activity and proliferation of AGS cells. Our data may provide some clues for the treatment of gastric cancer associated with Wnt signaling activation.</description><subject>Base Sequence</subject><subject>DNA methylation</subject><subject>DNA Primers</subject><subject>Gastric cancer</subject><subject>Gli1</subject><subject>Hedgehog Proteins - metabolism</subject><subject>Hedgehog signaling</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Heparan sulfate</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kinases</subject><subject>Ligands</subject><subject>Morphogenesis</subject><subject>Mutation</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Signal Transduction</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Surgery</subject><subject>Wnt Proteins - metabolism</subject><subject>Wnt signaling</subject><subject>β-catenin</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctqGzEUFaElcZP-QSgDhe5mevWWN4Fg0iYQ6KItWQpZumPLGc-40rjFf19NbQhk05VAnHPueRByTaGhQNXnTeNd3-HYMADdUNYAhzMyo0azWs8NvCGz8iNqbri8IO9y3gCAFFqekwtqmOCSzWfELNKQ8-i652poqzWGFa6HVeX6UD31Y7Vz4_qPO-Qq9tXK5TFFX5WzHtMVedu6LuP703tJfn65-7G4rx-_fX1Y3D7WXgg-1l5pWEq5RO6UoAbmbeDBK2MUogoAIjDJpFHSSVfsOsUZQ7nkrKWtN63nl-TTUXeXhl97zKPdxuyx61yPwz5bDSWJAVmAH18BN8M-9cWbpfJfcE15QYkjyk-5E7Z2l-LWpYOlYKde7cYee7VTr5YyW2wV2oeT-H65xfBCOhVZADdHAJYufkdMNvuIpagQE_rRhiH-78JrAd_FPvqyDB4wv2SxuRDs92nbaVrQAIprwf8CPFOdgw</recordid><startdate>20080508</startdate><enddate>20080508</enddate><creator>Yanai, Kosuke</creator><creator>Nakamura, Masafumi</creator><creator>Akiyoshi, Takashi</creator><creator>Nagai, Shuntaro</creator><creator>Wada, Junji</creator><creator>Koga, Kenichiro</creator><creator>Noshiro, Hirokazu</creator><creator>Nagai, Eishi</creator><creator>Tsuneyoshi, Masazumi</creator><creator>Tanaka, Masao</creator><creator>Katano, Mitsuo</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20080508</creationdate><title>Crosstalk of hedgehog and Wnt pathways in gastric cancer</title><author>Yanai, Kosuke ; Nakamura, Masafumi ; Akiyoshi, Takashi ; Nagai, Shuntaro ; Wada, Junji ; Koga, Kenichiro ; Noshiro, Hirokazu ; Nagai, Eishi ; Tsuneyoshi, Masazumi ; Tanaka, Masao ; Katano, Mitsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-c670b55be3a641809fd3dc6886ee6d004d2525865a5a030a6322e5b32f1fc8fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Base Sequence</topic><topic>DNA methylation</topic><topic>DNA Primers</topic><topic>Gastric cancer</topic><topic>Gli1</topic><topic>Hedgehog Proteins - metabolism</topic><topic>Hedgehog signaling</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Heparan sulfate</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kinases</topic><topic>Ligands</topic><topic>Morphogenesis</topic><topic>Mutation</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Signal Transduction</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Surgery</topic><topic>Wnt Proteins - metabolism</topic><topic>Wnt signaling</topic><topic>β-catenin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yanai, Kosuke</creatorcontrib><creatorcontrib>Nakamura, Masafumi</creatorcontrib><creatorcontrib>Akiyoshi, Takashi</creatorcontrib><creatorcontrib>Nagai, Shuntaro</creatorcontrib><creatorcontrib>Wada, Junji</creatorcontrib><creatorcontrib>Koga, Kenichiro</creatorcontrib><creatorcontrib>Noshiro, Hirokazu</creatorcontrib><creatorcontrib>Nagai, Eishi</creatorcontrib><creatorcontrib>Tsuneyoshi, Masazumi</creatorcontrib><creatorcontrib>Tanaka, Masao</creatorcontrib><creatorcontrib>Katano, Mitsuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yanai, Kosuke</au><au>Nakamura, Masafumi</au><au>Akiyoshi, Takashi</au><au>Nagai, Shuntaro</au><au>Wada, Junji</au><au>Koga, Kenichiro</au><au>Noshiro, Hirokazu</au><au>Nagai, Eishi</au><au>Tsuneyoshi, Masazumi</au><au>Tanaka, Masao</au><au>Katano, Mitsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Crosstalk of hedgehog and Wnt pathways in gastric cancer</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2008-05-08</date><risdate>2008</risdate><volume>263</volume><issue>1</issue><spage>145</spage><epage>156</epage><pages>145-156</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Abstract Morphogenic signals like Hedgehog (Hh) and Wnt are reported to play critical roles in the progression of gastric cancer. We aimed to assess the relationship between Hh and Wnt signaling pathways. In 58 gastric cancer specimens, Wnt pathway activation was inversely correlated with Hh pathway activation. When AGS gastric cancer cells, in which Wnt signaling was constitutively active, were used as a target cell line, Gli1 overexpression suppressed Wnt transcriptional activity, nuclear β-catenin accumulation and proliferation of AGS cells. Knock-down of β-catenin by siRNA suppressed Wnt pathway activity and proliferation of AGS cells. Our data may provide some clues for the treatment of gastric cancer associated with Wnt signaling activation.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>18243529</pmid><doi>10.1016/j.canlet.2007.12.030</doi><tpages>12</tpages></addata></record> |
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| subjects | Base Sequence DNA methylation DNA Primers Gastric cancer Gli1 Hedgehog Proteins - metabolism Hedgehog signaling Hematology, Oncology and Palliative Medicine Heparan sulfate Humans Immunohistochemistry Kinases Ligands Morphogenesis Mutation Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Stomach Neoplasms - metabolism Surgery Wnt Proteins - metabolism Wnt signaling β-catenin |
| title | Crosstalk of hedgehog and Wnt pathways in gastric cancer |
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