Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension

Endothelial dysfunction in the setting of cardiovascular risk factors such as hypercholesterolemia, diabetes mellitus, chronic smoking, as well hypertension, is, at least in part, dependent of the production of reactive oxygen species (ROS) and the subsequent decrease in vascular bioavailability of...

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Veröffentlicht in:	Antioxidants & redox signaling 2008-06, Vol.10 (6), p.1115-1126
Hauptverfasser:	Schulz, Eberhard, Jansen, Thomas, Wenzel, Philip, Daiber, Andreas, Münzel, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biopterins - analogs & derivatives Biopterins - metabolism Complications and side effects Cyclic GMP-Dependent Protein Kinases - metabolism Diagnosis Endothelium, Vascular - enzymology Endothelium, Vascular - metabolism Endothelium, Vascular - physiopathology Guanylate Cyclase - metabolism Health aspects Humans Hypertension Hypertension - enzymology Hypertension - physiopathology NADPH Oxidases - metabolism Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Oxidative Stress Peroxynitrous Acid - metabolism Receptors, Cytoplasmic and Nuclear - metabolism Risk factors Soluble Guanylyl Cyclase
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