Oral DNA vaccines target the tumor vasculature and microenvironment and suppress tumor growth and metastasis

Four novel oral DNA vaccines provide protection against melanoma, colon, breast, and lung carcinoma in mouse models. Vaccines are delivered by attenuated Salmonella typhimurium to secondary lymphoid organs and respectively target vascular endothelial growth factor receptor-2, transcription factor Fo...

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Veröffentlicht in:	Immunological reviews 2008-04, Vol.222 (1), p.117-128
Hauptverfasser:	Xiang, Rong, Luo, Yunping, Niethammer, Andreas G, Reisfeld, Ralph A
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral angiogenesis Animals CD8-Positive T-Lymphocytes - immunology Chemokine CCL21 - immunology cytotoxic T cells DNA vaccines Gene Transfer Techniques Immunologic Memory Immunotherapy Inhibitor of Apoptosis Proteins Interleukin-18 - immunology Killer Cells, Natural - immunology Lymphocyte Activation Mice Microtubule-Associated Proteins - immunology Neoplasm Invasiveness Neoplasms, Experimental - blood supply Neoplasms, Experimental - immunology Neoplasms, Experimental - therapy Neovascularization, Pathologic - immunology Neovascularization, Pathologic - pathology Neovascularization, Pathologic - prevention & control Proto-Oncogene Proteins c-fos - immunology Repressor Proteins Salmonella typhimurium Self Tolerance - immunology tumor microenvironment tumor suppression tumor vasculature Vaccines, DNA - administration & dosage Vaccines, DNA - immunology Vaccines, DNA - therapeutic use Vascular Endothelial Growth Factor Receptor-2 - immunology
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