Rectal Augmentation : Short-and Mid-Term Evaluation of a Novel Procedure for Severe Fecal Urgency With Associated Incontinence
Rectal augmentation (RA) with or without electrically stimulated gracilis neosphincter (ESGN) was developed to address the physiologic and anatomic abnormalities present in a subset of patients with incapacitating fecal urgency and associated urge fecal incontinence (UFI). This study evaluated the s...
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Veröffentlicht in: | Annals of surgery 2008-03, Vol.247 (3), p.421-427 |
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creator | MURPHY, Jamie CHAN, Christopher L. H SCOTT, S. Mark VASUDEVAN, Subash P LUNNISS, Peter J WILLIAMS, Norman S |
description | Rectal augmentation (RA) with or without electrically stimulated gracilis neosphincter (ESGN) was developed to address the physiologic and anatomic abnormalities present in a subset of patients with incapacitating fecal urgency and associated urge fecal incontinence (UFI). This study evaluated the short- and medium-term clinical and physiologic results.
Eleven patients with fecal urgency and UFI underwent RA, 6 with concomitant ESGN formation. Patients were evaluated preoperatively, and at a median of 12.5 and 54 months after surgery.
At 4.5 years, 7/11 patients had avoided stoma construction. Symptoms recurred leading to permanent stoma formation in 1 patient, whereas one other developed evacuatory difficulty with overflow incontinence. Median ability to defer defecation improved from seconds preoperatively to 10 minutes at 1 year (P = 0.0002), and 15 minutes at 4.5 years (P = 0.002). Median Wexner incontinence scores improved from 15 preoperatively to 3 at 1 year (P = 0.002), and 4 at 4.5 years (P = 0.02). At 1 year, 2 of the rectal sensory thresholds (DDV: P = 0.008; MTV: P = 0.008) and compliance were normalized (P = 0.008), whereas at 4.5 years, all sensation thresholds improved (FCS: P = 0.002; DDV: P = 0.002; MTV: P = 0.002), but changes in compliance were not significant.
RA with or without ESGN improved reported symptoms and normalized rectal sensation. Improvements were sustained in the medium term. The procedure had no associated morbidity or mortality, and should be considered in the surgical management of a select group of patients presenting with severe urgency and UFI. |
doi_str_mv | 10.1097/SLA.0b013e31815f9885 |
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Eleven patients with fecal urgency and UFI underwent RA, 6 with concomitant ESGN formation. Patients were evaluated preoperatively, and at a median of 12.5 and 54 months after surgery.
At 4.5 years, 7/11 patients had avoided stoma construction. Symptoms recurred leading to permanent stoma formation in 1 patient, whereas one other developed evacuatory difficulty with overflow incontinence. Median ability to defer defecation improved from seconds preoperatively to 10 minutes at 1 year (P = 0.0002), and 15 minutes at 4.5 years (P = 0.002). Median Wexner incontinence scores improved from 15 preoperatively to 3 at 1 year (P = 0.002), and 4 at 4.5 years (P = 0.02). At 1 year, 2 of the rectal sensory thresholds (DDV: P = 0.008; MTV: P = 0.008) and compliance were normalized (P = 0.008), whereas at 4.5 years, all sensation thresholds improved (FCS: P = 0.002; DDV: P = 0.002; MTV: P = 0.002), but changes in compliance were not significant.
RA with or without ESGN improved reported symptoms and normalized rectal sensation. Improvements were sustained in the medium term. The procedure had no associated morbidity or mortality, and should be considered in the surgical management of a select group of patients presenting with severe urgency and UFI.</description><identifier>ISSN: 0003-4932</identifier><identifier>EISSN: 1528-1140</identifier><identifier>DOI: 10.1097/SLA.0b013e31815f9885</identifier><identifier>PMID: 18376184</identifier><identifier>CODEN: ANSUA5</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott</publisher><subject>Adult ; Anal Canal - physiology ; Biological and medical sciences ; Defecation ; Digestive System Surgical Procedures - methods ; Electric Stimulation Therapy ; Fecal Incontinence - surgery ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Humans ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Quality of Life ; Rectum - abnormalities ; Rectum - innervation ; Rectum - surgery ; Recurrence ; Sensory Thresholds ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Time Factors ; Treatment Outcome</subject><ispartof>Annals of surgery, 2008-03, Vol.247 (3), p.421-427</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c284t-db7707a507424a97c4b344f84f6ca503aa7dd5e8a1977b05ee67ea11550ebfd53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20122844$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18376184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MURPHY, Jamie</creatorcontrib><creatorcontrib>CHAN, Christopher L. H</creatorcontrib><creatorcontrib>SCOTT, S. Mark</creatorcontrib><creatorcontrib>VASUDEVAN, Subash P</creatorcontrib><creatorcontrib>LUNNISS, Peter J</creatorcontrib><creatorcontrib>WILLIAMS, Norman S</creatorcontrib><title>Rectal Augmentation : Short-and Mid-Term Evaluation of a Novel Procedure for Severe Fecal Urgency With Associated Incontinence</title><title>Annals of surgery</title><addtitle>Ann Surg</addtitle><description>Rectal augmentation (RA) with or without electrically stimulated gracilis neosphincter (ESGN) was developed to address the physiologic and anatomic abnormalities present in a subset of patients with incapacitating fecal urgency and associated urge fecal incontinence (UFI). This study evaluated the short- and medium-term clinical and physiologic results.
Eleven patients with fecal urgency and UFI underwent RA, 6 with concomitant ESGN formation. Patients were evaluated preoperatively, and at a median of 12.5 and 54 months after surgery.
At 4.5 years, 7/11 patients had avoided stoma construction. Symptoms recurred leading to permanent stoma formation in 1 patient, whereas one other developed evacuatory difficulty with overflow incontinence. Median ability to defer defecation improved from seconds preoperatively to 10 minutes at 1 year (P = 0.0002), and 15 minutes at 4.5 years (P = 0.002). Median Wexner incontinence scores improved from 15 preoperatively to 3 at 1 year (P = 0.002), and 4 at 4.5 years (P = 0.02). At 1 year, 2 of the rectal sensory thresholds (DDV: P = 0.008; MTV: P = 0.008) and compliance were normalized (P = 0.008), whereas at 4.5 years, all sensation thresholds improved (FCS: P = 0.002; DDV: P = 0.002; MTV: P = 0.002), but changes in compliance were not significant.
RA with or without ESGN improved reported symptoms and normalized rectal sensation. Improvements were sustained in the medium term. The procedure had no associated morbidity or mortality, and should be considered in the surgical management of a select group of patients presenting with severe urgency and UFI.</description><subject>Adult</subject><subject>Anal Canal - physiology</subject><subject>Biological and medical sciences</subject><subject>Defecation</subject><subject>Digestive System Surgical Procedures - methods</subject><subject>Electric Stimulation Therapy</subject><subject>Fecal Incontinence - surgery</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Quality of Life</subject><subject>Rectum - abnormalities</subject><subject>Rectum - innervation</subject><subject>Rectum - surgery</subject><subject>Recurrence</subject><subject>Sensory Thresholds</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0003-4932</issn><issn>1528-1140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkN9rFDEQx4Mo9qz-ByJ50betk01yyfp2lFYL5w-8Fh-XbDJpV3aTNske9MW_3cgdCj7NMPOZL8yHkNcMzhh06v1uuzmDARhHzjSTvtNaPiErJlvdMCbgKVkBAG9Ex9sT8iLnnwBMaFDPyQnTXK2ZFivy6zvaYia6WW5nDMWUMQb6ge7uYiqNCY5-Hl1zjWmmF3szLYd99NTQL3GPE_2WokW3JKQ-JrrDPdb2Em2NvEm3GOwj_TGWO7rJOdrRFHT0KtgYyhjqEl-SZ95MGV8d6ym5uby4Pv_UbL9-vDrfbBvbalEaNygFykhQohWmU1YMXAivhV_bOuXGKOckasM6pQaQiGuFhjEpAQfvJD8l7w659yk-LJhLP4_Z4jSZgHHJvQJRA2VXQXEAbYo5J_T9fRpnkx57Bv0f73313v_vvZ69OeYvw4zu39FRdAXeHgGTqxyfTLBj_su1wNr6qeC_AWqfjMI</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>MURPHY, Jamie</creator><creator>CHAN, Christopher L. H</creator><creator>SCOTT, S. Mark</creator><creator>VASUDEVAN, Subash P</creator><creator>LUNNISS, Peter J</creator><creator>WILLIAMS, Norman S</creator><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080301</creationdate><title>Rectal Augmentation : Short-and Mid-Term Evaluation of a Novel Procedure for Severe Fecal Urgency With Associated Incontinence</title><author>MURPHY, Jamie ; CHAN, Christopher L. H ; SCOTT, S. Mark ; VASUDEVAN, Subash P ; LUNNISS, Peter J ; WILLIAMS, Norman S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-db7707a507424a97c4b344f84f6ca503aa7dd5e8a1977b05ee67ea11550ebfd53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Anal Canal - physiology</topic><topic>Biological and medical sciences</topic><topic>Defecation</topic><topic>Digestive System Surgical Procedures - methods</topic><topic>Electric Stimulation Therapy</topic><topic>Fecal Incontinence - surgery</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Quality of Life</topic><topic>Rectum - abnormalities</topic><topic>Rectum - innervation</topic><topic>Rectum - surgery</topic><topic>Recurrence</topic><topic>Sensory Thresholds</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MURPHY, Jamie</creatorcontrib><creatorcontrib>CHAN, Christopher L. H</creatorcontrib><creatorcontrib>SCOTT, S. Mark</creatorcontrib><creatorcontrib>VASUDEVAN, Subash P</creatorcontrib><creatorcontrib>LUNNISS, Peter J</creatorcontrib><creatorcontrib>WILLIAMS, Norman S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MURPHY, Jamie</au><au>CHAN, Christopher L. H</au><au>SCOTT, S. Mark</au><au>VASUDEVAN, Subash P</au><au>LUNNISS, Peter J</au><au>WILLIAMS, Norman S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rectal Augmentation : Short-and Mid-Term Evaluation of a Novel Procedure for Severe Fecal Urgency With Associated Incontinence</atitle><jtitle>Annals of surgery</jtitle><addtitle>Ann Surg</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>247</volume><issue>3</issue><spage>421</spage><epage>427</epage><pages>421-427</pages><issn>0003-4932</issn><eissn>1528-1140</eissn><coden>ANSUA5</coden><abstract>Rectal augmentation (RA) with or without electrically stimulated gracilis neosphincter (ESGN) was developed to address the physiologic and anatomic abnormalities present in a subset of patients with incapacitating fecal urgency and associated urge fecal incontinence (UFI). This study evaluated the short- and medium-term clinical and physiologic results.
Eleven patients with fecal urgency and UFI underwent RA, 6 with concomitant ESGN formation. Patients were evaluated preoperatively, and at a median of 12.5 and 54 months after surgery.
At 4.5 years, 7/11 patients had avoided stoma construction. Symptoms recurred leading to permanent stoma formation in 1 patient, whereas one other developed evacuatory difficulty with overflow incontinence. Median ability to defer defecation improved from seconds preoperatively to 10 minutes at 1 year (P = 0.0002), and 15 minutes at 4.5 years (P = 0.002). Median Wexner incontinence scores improved from 15 preoperatively to 3 at 1 year (P = 0.002), and 4 at 4.5 years (P = 0.02). At 1 year, 2 of the rectal sensory thresholds (DDV: P = 0.008; MTV: P = 0.008) and compliance were normalized (P = 0.008), whereas at 4.5 years, all sensation thresholds improved (FCS: P = 0.002; DDV: P = 0.002; MTV: P = 0.002), but changes in compliance were not significant.
RA with or without ESGN improved reported symptoms and normalized rectal sensation. Improvements were sustained in the medium term. The procedure had no associated morbidity or mortality, and should be considered in the surgical management of a select group of patients presenting with severe urgency and UFI.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott</pub><pmid>18376184</pmid><doi>10.1097/SLA.0b013e31815f9885</doi><tpages>7</tpages></addata></record> |
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subjects | Adult Anal Canal - physiology Biological and medical sciences Defecation Digestive System Surgical Procedures - methods Electric Stimulation Therapy Fecal Incontinence - surgery Female Gastroenterology. Liver. Pancreas. Abdomen General aspects Humans Male Medical sciences Middle Aged Other diseases. Semiology Quality of Life Rectum - abnormalities Rectum - innervation Rectum - surgery Recurrence Sensory Thresholds Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Time Factors Treatment Outcome |
title | Rectal Augmentation : Short-and Mid-Term Evaluation of a Novel Procedure for Severe Fecal Urgency With Associated Incontinence |
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