Rectal Augmentation : Short-and Mid-Term Evaluation of a Novel Procedure for Severe Fecal Urgency With Associated Incontinence

Rectal augmentation (RA) with or without electrically stimulated gracilis neosphincter (ESGN) was developed to address the physiologic and anatomic abnormalities present in a subset of patients with incapacitating fecal urgency and associated urge fecal incontinence (UFI). This study evaluated the s...

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Veröffentlicht in:Annals of surgery 2008-03, Vol.247 (3), p.421-427
Hauptverfasser: MURPHY, Jamie, CHAN, Christopher L. H, SCOTT, S. Mark, VASUDEVAN, Subash P, LUNNISS, Peter J, WILLIAMS, Norman S
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container_end_page 427
container_issue 3
container_start_page 421
container_title Annals of surgery
container_volume 247
creator MURPHY, Jamie
CHAN, Christopher L. H
SCOTT, S. Mark
VASUDEVAN, Subash P
LUNNISS, Peter J
WILLIAMS, Norman S
description Rectal augmentation (RA) with or without electrically stimulated gracilis neosphincter (ESGN) was developed to address the physiologic and anatomic abnormalities present in a subset of patients with incapacitating fecal urgency and associated urge fecal incontinence (UFI). This study evaluated the short- and medium-term clinical and physiologic results. Eleven patients with fecal urgency and UFI underwent RA, 6 with concomitant ESGN formation. Patients were evaluated preoperatively, and at a median of 12.5 and 54 months after surgery. At 4.5 years, 7/11 patients had avoided stoma construction. Symptoms recurred leading to permanent stoma formation in 1 patient, whereas one other developed evacuatory difficulty with overflow incontinence. Median ability to defer defecation improved from seconds preoperatively to 10 minutes at 1 year (P = 0.0002), and 15 minutes at 4.5 years (P = 0.002). Median Wexner incontinence scores improved from 15 preoperatively to 3 at 1 year (P = 0.002), and 4 at 4.5 years (P = 0.02). At 1 year, 2 of the rectal sensory thresholds (DDV: P = 0.008; MTV: P = 0.008) and compliance were normalized (P = 0.008), whereas at 4.5 years, all sensation thresholds improved (FCS: P = 0.002; DDV: P = 0.002; MTV: P = 0.002), but changes in compliance were not significant. RA with or without ESGN improved reported symptoms and normalized rectal sensation. Improvements were sustained in the medium term. The procedure had no associated morbidity or mortality, and should be considered in the surgical management of a select group of patients presenting with severe urgency and UFI.
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Symptoms recurred leading to permanent stoma formation in 1 patient, whereas one other developed evacuatory difficulty with overflow incontinence. Median ability to defer defecation improved from seconds preoperatively to 10 minutes at 1 year (P = 0.0002), and 15 minutes at 4.5 years (P = 0.002). Median Wexner incontinence scores improved from 15 preoperatively to 3 at 1 year (P = 0.002), and 4 at 4.5 years (P = 0.02). At 1 year, 2 of the rectal sensory thresholds (DDV: P = 0.008; MTV: P = 0.008) and compliance were normalized (P = 0.008), whereas at 4.5 years, all sensation thresholds improved (FCS: P = 0.002; DDV: P = 0.002; MTV: P = 0.002), but changes in compliance were not significant. RA with or without ESGN improved reported symptoms and normalized rectal sensation. Improvements were sustained in the medium term. 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Mark</creatorcontrib><creatorcontrib>VASUDEVAN, Subash P</creatorcontrib><creatorcontrib>LUNNISS, Peter J</creatorcontrib><creatorcontrib>WILLIAMS, Norman S</creatorcontrib><title>Rectal Augmentation : Short-and Mid-Term Evaluation of a Novel Procedure for Severe Fecal Urgency With Associated Incontinence</title><title>Annals of surgery</title><addtitle>Ann Surg</addtitle><description>Rectal augmentation (RA) with or without electrically stimulated gracilis neosphincter (ESGN) was developed to address the physiologic and anatomic abnormalities present in a subset of patients with incapacitating fecal urgency and associated urge fecal incontinence (UFI). This study evaluated the short- and medium-term clinical and physiologic results. Eleven patients with fecal urgency and UFI underwent RA, 6 with concomitant ESGN formation. Patients were evaluated preoperatively, and at a median of 12.5 and 54 months after surgery. At 4.5 years, 7/11 patients had avoided stoma construction. 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source MEDLINE; Journals@Ovid Complete; PubMed Central
subjects Adult
Anal Canal - physiology
Biological and medical sciences
Defecation
Digestive System Surgical Procedures - methods
Electric Stimulation Therapy
Fecal Incontinence - surgery
Female
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Humans
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Quality of Life
Rectum - abnormalities
Rectum - innervation
Rectum - surgery
Recurrence
Sensory Thresholds
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Time Factors
Treatment Outcome
title Rectal Augmentation : Short-and Mid-Term Evaluation of a Novel Procedure for Severe Fecal Urgency With Associated Incontinence
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