Identification and function of phosphorylation in the glucose-regulated transcription factor ChREBP

In the liver, induction of genes encoding enzymes involved in de novo lipogenesis occurs in response to increased glucose metabolism. ChREBP (carbohydrate-response-element-binding protein) is a basic helix-loop-helix/leucine zipper transcription factor that regulates expression of these genes. To ev...

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Veröffentlicht in:	Biochemical journal 2008-04, Vol.411 (2), p.261-270
Hauptverfasser:	Tsatsos, Nikolas G, Davies, Michael N, O'Callaghan, Brennon L, Towle, Howard C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - chemistry Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism Cells, Cultured Glucose - pharmacology Humans Male Mass Spectrometry Molecular Sequence Data Mutation - genetics Phosphorylation - drug effects Rats
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