Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents

The emergence of resistance to existing antibiotics demands the development of novel antimicrobial agents directed against novel targets. Historically, bacterial cell wall synthesis, protein, and DNA and RNA synthesis have been major targets of very successful classes of antibiotics such as -lactams...

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Veröffentlicht in:	Expert opinion on investigational drugs 2007-05, Vol.16 (5), p.573-593
Hauptverfasser:	Ochsner, Urs A, Sun, Xicheng, Jarvis, Thale, Critchley, Ian, Janjic, Nebojsa
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acyl-tRNA Synthetases - antagonists & inhibitors Amino Acyl-tRNA Synthetases - metabolism aminoacyl-adenylate analogs aminoacyl-tRNA synthetase AN-2690 Animals Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use antibiotics Bacteria - drug effects Bacteria - enzymology Drug Design Drug Resistance, Multiple, Bacterial Drugs, Investigational - chemistry Drugs, Investigational - pharmacology Drugs, Investigational - therapeutic use Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use high-throughput screening Humans icofungipen indolmycin MRSA mupirocin Mupirocin - chemistry Mupirocin - pharmacology Mupirocin - therapeutic use REP8839 topical agents Treatment Outcome
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