Pulmonary vascular remodeling
The maladaptive response of the pulmonary vasculature that occurs in patients with congenital diaphragmatic hernia significantly impacts outcome. Muscularized distal pulmonary arterioles inhibit the ability of the neonate to adjust to extrauterine circulation, resulting in severe pulmonary hypertens...
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| Veröffentlicht in: | Seminars in pediatric surgery 2007-05, Vol.16 (2), p.80-87 |
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| container_title | Seminars in pediatric surgery |
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| creator | Miniati, Doug, MD |
| description | The maladaptive response of the pulmonary vasculature that occurs in patients with congenital diaphragmatic hernia significantly impacts outcome. Muscularized distal pulmonary arterioles inhibit the ability of the neonate to adjust to extrauterine circulation, resulting in severe pulmonary hypertension. This review summarizes the current state of knowledge regarding normal and abnormal development of the lung vascular system and identifies current and potential therapies directed toward preserving or restoring proper pulmonary vascular function. |
| doi_str_mv | 10.1053/j.sempedsurg.2007.01.002 |
| format | Article |
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Muscularized distal pulmonary arterioles inhibit the ability of the neonate to adjust to extrauterine circulation, resulting in severe pulmonary hypertension. 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| fulltext | fulltext |
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| ispartof | Seminars in pediatric surgery, 2007-05, Vol.16 (2), p.80-87 |
| issn | 1055-8586 1532-9453 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Arterioles - growth & development Congenital diaphragmatic hernia Development Hernias, Diaphragmatic, Congenital Humans Hypertension, Pulmonary - etiology Hypertension, Pulmonary - therapy Lung Lung - blood supply Pediatrics Pulmonary Circulation - physiology Pulmonary hypertension Surgery Vascular remodeling Vasculogenesis |
| title | Pulmonary vascular remodeling |
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